{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:02Z","timestamp":1791229622644,"version":"4.1.0"},"reference-count":135,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s393809","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T22:20:13Z","timestamp":1680042013000},"page":"1081-1094","source":"Crossref","is-referenced-by-count":78,"title":["An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Christophe","family":"Mallet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-1795","authenticated-orcid":true,"given":"Jules","family":"Desmeules","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-4735","authenticated-orcid":true,"given":"Rassa","family":"Pegahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Eschalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/17460441.2017.1261108","volume":"12","author":"Nagakura","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/BCPT.12527","volume":"118","author":"Ennis","year":"2016","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.amjopharm.2012.09.004","volume":"10","author":"O\u2019Neil","year":"2012","journal-title":"Am J Geriatr Pharmacother"},{"key":"ref4","doi-asserted-by":"publisher","volume-title":"Landmark Papers in Pain: Seminal Papers in Pain with Expert Commentaries","year":"2018","DOI":"10.1093\/MED\/9780198834359.003.0004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153420","volume":"10","author":"Freo","year":"2021","journal-title":"J Clin Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03007995.2022.2049551","author":"Alchin","year":"2022","journal-title":"Curr Med Res Opin"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1527-3458.2006.00250.x","volume":"12","author":"Bertolini","year":"2006","journal-title":"CNS Drug Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/240410A0","volume":"240","author":"Flower","year":"1972","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e00835","DOI":"10.1002\/prp2.835","volume":"9","author":"Esh","year":"2021","journal-title":"Pharmacol Res Perspect"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"580289","DOI":"10.3389\/fphar.2020.580289","volume":"11","author":"Ohashi","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13392","author":"Przyby\u0142a","year":"2020","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5772\/66649","author":"Mallet","year":"2017","journal-title":"Pain Reli"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10787-013-0172-x","volume":"21","author":"Graham","year":"2013","journal-title":"Inflammopharmacology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/J.1365-2710.2009.01143.X","volume":"35","author":"Toussaint","year":"2010","journal-title":"J Clin Pharm Ther"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejphar.2004.08.055","volume":"503","author":"Raffa","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"31405","DOI":"10.1074\/JBC.M501489200","volume":"280","author":"H\u00f6gest\u00e4tt","year":"2005","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/J.PAIN.2008.03.030","volume":"139","author":"Mallet","year":"2008","journal-title":"Pain"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0070690","volume":"8","author":"Barri\u00e8re","year":"2013","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/J.NEUROPHARM.2014.11.006","volume":"91","author":"Dalmann","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5812\/AAPM.32873","volume":"6","author":"Muramatsu","year":"2016","journal-title":"Anesthesiol Pain Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/S12974-017-1014-3","volume":"14","author":"Saliba","year":"2017","journal-title":"J Neuroinflammation"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1021\/acs.molpharmaceut.9b00508","volume":"16","author":"Sodano","year":"2019","journal-title":"Mol Pharm"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4103\/0253-7613.153431","volume":"47","author":"Parashar","year":"2015","journal-title":"Indian J Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1016\/J.BMCL.2010.05.050","volume":"20","author":"Wu","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/S10787-998-0031-3","volume":"6","author":"Fadl","year":"1998","journal-title":"Inflammopharmacology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1016\/0006-2952(82)90565-2","volume":"31","author":"Hanel","year":"1982","journal-title":"Biochem Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1096\/FJ.06-8015COM","volume":"22","author":"Schildknecht","year":"2008","journal-title":"FASEB J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/ABBI.2000.2232","volume":"387","author":"Ouellet","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/FJ.04-2437FJE","volume":"19","author":"Lucas","year":"2005","journal-title":"FASEB J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1073\/PNAS.102588199\/ASSET\/682AB754-3CF6-4EC9-B4FB-18483C903C21\/ASSETS\/GRAPHIC\/PQ1025881008.JPEG","volume":"99","author":"Boutaud","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00045391-200501000-00008","volume":"12","author":"Graham","year":"2005","journal-title":"Am J Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.clpt.2005.09.009","volume":"79","author":"Aronoff","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"32783","DOI":"10.1074\/JBC.M003505200","volume":"275","author":"Murakami","year":"2000","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"13926","DOI":"10.1073\/pnas.162468699","volume":"99","author":"Chandrasekharan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1096\/FJ.03-0595LTE","volume":"17","author":"Schwab","year":"2003","journal-title":"FASEB J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0165-2478(02)00268-7","volume":"86","author":"Dinchuk","year":"2003","journal-title":"Immunol Lett"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0012748","volume":"5","author":"Mallet","year":"2010","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/23328940.2021.1886392","volume":"8","author":"Ayoub","year":"2021","journal-title":"Temperature"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/J.NEUROPHARM.2013.03.012","volume":"71","author":"Engstr\u00f6m Ruud","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1113\/JPHYSIOL.1973.SP010071","volume":"228","author":"Feldberg","year":"1973","journal-title":"J Physiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"11165","DOI":"10.1073\/PNAS.0404185101","volume":"101","author":"Ayoub","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.1096\/fj.201800272R","volume":"32","author":"Mirrasekhian","year":"2018","journal-title":"FASEB J"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.2147\/JPR.S143500","volume":"10","author":"Sharma","year":"2017","journal-title":"J Pain Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1200\/JCO.2007.15.0235","volume":"26","author":"Rastogi","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/J.PAIN.2014.01.015","volume":"155","author":"Kerckhove","year":"2014","journal-title":"Pain"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/ALN.0000000000001700","volume":"127","author":"Ohashi","year":"2017","journal-title":"Anesthesiology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3390\/CELLS3030914","volume":"3","author":"Ryskamp","year":"2014","journal-title":"Cells"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/J.1476-5381.2011.01214.X","volume":"163","author":"Liao","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0014-2999(00)00207-7","volume":"396","author":"Zygmunt","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1111\/bph.14934","volume":"177","author":"Barri\u00e8re","year":"2020","journal-title":"Br J Pharmacol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/PM\/PNZ037","volume":"21","author":"Pickering","year":"2020","journal-title":"Pain Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1097\/J.PAIN.0000000000000469","volume":"157","author":"Bourinet","year":"2016","journal-title":"Pain"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13041-022-00923-W","volume":"15","author":"Harding","year":"2022","journal-title":"Mol Brain"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/J.PAIN.2012.10.023","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"13106","DOI":"10.1523\/JNEUROSCI.2919-09.2009","volume":"29","author":"Barbara","year":"2009","journal-title":"J Neurosci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/J.EJPHAR.2005.12.015","volume":"531","author":"Ottani","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/J.NEUROPHARM.2009.12.010","volume":"58","author":"Hama","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.brainresrev.2008.12.009","volume":"60","author":"Heinricher","year":"2009","journal-title":"Brain Res Rev"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0014-2999(91)90036-P","volume":"193","author":"Tj\u00f8lsen","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ejphar.2011.12.016","volume":"677","author":"Dogrul","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s002100100484","volume":"364","author":"Courade","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/J.CLPT.2005.12.307","volume":"79","author":"Pickering","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/J.BIOPHA.2021.112578","author":"Nakamura","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/J.1472-8206.1996.TB00593.X","volume":"10","author":"Alloui","year":"1996","journal-title":"Fundam Clin Pharmacol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0014-2999(02)01578-9","volume":"443","author":"Alloui","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/00000542-200310000-00034","volume":"99","author":"Bonnefont","year":"2003","journal-title":"Anesthesiology"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/J.PAIN.2005.01.019","volume":"114","author":"Bonnefont","year":"2005","journal-title":"Pain"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1124\/MOL.106.025775","volume":"71","author":"Bonnefont","year":"2007","journal-title":"Mol Pharmacol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/J.NEULET.2012.12.052","volume":"536","author":"Liu","year":"2013","journal-title":"Neurosci Lett"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/SJ.CLPT.6100403","volume":"84","author":"Pickering","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1248\/BPB.B21-00178","volume":"44","author":"Yamaguchi","year":"2021","journal-title":"Biol Pharm Bull"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/J.1472-8206.2011.00933.X","volume":"26","author":"Pickering","year":"2012","journal-title":"Fundam Clin Pharmacol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/J.PAIN.2011.02.003","volume":"152","author":"Bandschapp","year":"2011","journal-title":"Pain"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4274\/TJPS.GALENOS.2018.35403","volume":"17","author":"Hamurtekin","year":"2020","journal-title":"Turkish J Pharm Sci"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/PHAR.1584","volume":"35","author":"Danelich","year":"2015","journal-title":"Pharmacother J Hum Pharmacol Drug Ther"},{"key":"ref76","first-page":"11","volume":"71","author":"Jozwiak-Bebenista","year":"2014","journal-title":"Acta Pol Pharm Drug Res"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/bcp.12802","volume":"81","author":"Hayward","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/annrheumdis-2016-209707","volume":"76","author":"Richette","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10194-010-0266-4","volume":"12","author":"Haag","year":"2011","journal-title":"J Headache Pain"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2174\/1876386301811010012","volume":"11","author":"Gaul","year":"2018","journal-title":"Open Pain J"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2076475","author":"Perrot","year":"2022","journal-title":"Curr Med Res Opin"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-2125.2006.02723.x","volume":"63","author":"McQuay","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/S002280050386","volume":"53","author":"Piguet","year":"1998","journal-title":"Eur J Clin Pharmacol"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010794.pub2","volume":"2017","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.11.003","volume":"34","author":"Qi","year":"2012","journal-title":"Clin Ther"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.3390\/GENES13030421\/S1","volume":"13","author":"Evke","year":"2022","journal-title":"Genes"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/J.ANNONC.2022.05.010","volume":"33","author":"Bessede","year":"2022","journal-title":"Ann Oncol off J Eur Soc Med Oncol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2215\/CJN.05180418","volume":"14","author":"Davison","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2147\/CLEP.S158110","volume":"10","author":"Hiragi","year":"2018","journal-title":"Clin Epidemiol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1093\/ndt\/gfn745","volume":"24","author":"Evans","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.2174\/1381612023394917","volume":"8","author":"Graham","year":"2005","journal-title":"Curr Pharm Des"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1177\/2054358120910329","author":"Davison","year":"2020","journal-title":"Can J Kidney Heal Dis"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/JCPH.1302","volume":"59","author":"Mart\u00edn Arias","year":"2019","journal-title":"J Clin Pharmacol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/1074248417751070","volume":"23","author":"White","year":"2018","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1097\/HJH.0b013e328360f6f8","volume":"31","author":"Dawson","year":"2013","journal-title":"J Hypertens"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1161\/HYPERTENSIONAHA.114.04945","volume":"65","author":"Fulton","year":"2015","journal-title":"Hypertension"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1111\/BCP.12032","volume":"75","author":"Turtle","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1161\/CIRCULATIONAHA.121.056015","volume":"145","author":"MacIntyre","year":"2022","journal-title":"Circulation"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41569-020-0366-z","volume":"17","author":"Schjerning","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.106.181424","volume":"115","author":"Antman","year":"2007","journal-title":"Circulation"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1248\/bpb.b19-00722","volume":"43","author":"Ishitsuka","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"BMJ Publishing Group Limited. What dose of paracetamol for older people? Drug Ther Bull. 2018;56(6):69\u201372. doi:10.1136\/dtb.2018.6.0636","DOI":"10.1136\/dtb.2018.6.0636"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/S0140-6736(11)60245-6","volume":"377","author":"Wu","year":"2011","journal-title":"Lancet"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1046\/j.1365-2710.2001.00355.x","volume":"26","author":"Raffa","year":"2001","journal-title":"J Clin Pharm Ther"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/00325481.2021.1985351","volume":"134","author":"Patel","year":"2022","journal-title":"Postgrad Med"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/S1474-4422(13)70193-5","volume":"12","author":"Gilron","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2165\/00003495-200363992-00003","volume":"63","author":"Bannwarth","year":"2003","journal-title":"Drugs"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/S10067-006-0202-9\/FIGURES\/5","volume":"25","author":"Schug","year":"2006","journal-title":"Clin Rheumatol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2165\/11205830-000000000-00000","volume":"30","author":"Dhillon","year":"2010","journal-title":"Clin Drug Investig"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1155\/2013\/402510","author":"Jebaraj","year":"2013","journal-title":"Pain Res Treat"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"737","DOI":"10.2217\/pmt-2021-0116","volume":"12","author":"Freo","year":"2022","journal-title":"Pain Manag"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s10787-021-00828-5","volume":"29","author":"Liu","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/AAS.12382","volume":"58","author":"Dahl","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/J.PAIN.2005.11.012","volume":"121","author":"Miranda","year":"2006","journal-title":"Pain"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1213\/ANE.0B013E3181CF9281","volume":"110","author":"Ong","year":"2010","journal-title":"Anesth Analg"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/J.EJPAIN.2011.08.009","volume":"16","author":"Moore","year":"2012","journal-title":"Eur J Pain"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1472-6904-10-10","volume":"10","author":"Tanner","year":"2010","journal-title":"BMC Clin Pharmacol"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.4172\/JBB.1000230","volume":"7","author":"Atkinson","year":"2015","journal-title":"J Bioequiv Availab"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010210.PUB2","volume":"2013","author":"Derry","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1001\/JAMA.2018.22039","volume":"321","author":"Thybo","year":"2019","journal-title":"JAMA"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/AAS.13496","volume":"64","author":"Thybo","year":"2020","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/J.PAIN.2010.12.012","volume":"152","author":"Daniels","year":"2011","journal-title":"Pain"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1111\/J.1524-4725.2011.02022.X","volume":"37","author":"Sniezek","year":"2011","journal-title":"Dermatol Surg"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.1245\/S10434-012-2447-7","volume":"19","author":"Mitchell","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/j.1572-0241.2008.01811.x","volume":"103","author":"Rahme","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000362649","volume":"93","author":"Mititelu Tartau","year":"2014","journal-title":"Pharmacology"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/J.1399-6576.2006.01237.X","volume":"51","author":"Durmus","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/J.EJMECH.2020.113042","author":"Johan","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"e113841","DOI":"10.1371\/journal.pone.0113841","volume":"9","author":"Fresno","year":"2014","journal-title":"PLoS One"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0149-2918(02)80010-8","volume":"24","author":"Fricke","year":"2002","journal-title":"Clin Ther"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/J.1834-7819.2002.TB00319.X","volume":"47","author":"Macleod","year":"2002","journal-title":"Aust Dent J"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.amjsurg.2003.12.038","volume":"187","author":"Smith","year":"2004","journal-title":"Am J Surg"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2147\/JPR.S16760","volume":"4","author":"Rawal","year":"2011","journal-title":"J Pain Res"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1186\/S12871-020-01115-6","volume":"20","author":"Aweke","year":"2020","journal-title":"BMC Anesthesiol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1016\/J.JSE.2021.03.132","volume":"30","author":"Singh","year":"2021","journal-title":"J Shoulder Elb Surg"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88551","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T22:20:23Z","timestamp":1680042023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/an-updated-review-on-the-metabolite-am404-mediated-central-mechanism-o-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":135,"URL":"https:\/\/doi.org\/10.2147\/jpr.s393809","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}