{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:07:30Z","timestamp":1747206450915,"version":"3.40.5"},"reference-count":37,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s405825","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T03:50:21Z","timestamp":1690429821000},"page":"2595-2607","source":"Crossref","is-referenced-by-count":1,"title":["Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Bruce H","family":"Chamberlain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Rhiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal E","family":"Slatkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-0722","authenticated-orcid":true,"given":"Nancy","family":"Stambler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1526-4637.2008.00495.x","volume":"10","author":"Bell","year":"2009","journal-title":"Pain Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0304-3959(01)00324-4","volume":"93","author":"Meuser","year":"2001","journal-title":"Pain"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/j.1742-1241.2007.01415.x","volume":"61","author":"Panchal","year":"2007","journal-title":"Int J Clin Pract"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1526-4637.2006.00184.x","volume":"7","author":"Weschules","year":"2006","journal-title":"Pain Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1111\/pme.12724","volume":"16","author":"Coyne","year":"2015","journal-title":"Pain Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/141737","author":"Kumar","year":"2014","journal-title":"Gastroenterol Res Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1177\/1756283X15578608","volume":"8","author":"Nelson","year":"2015","journal-title":"Therap Adv Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1111\/nmo.12417","volume":"26","author":"Camilleri","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"ref9","first-page":"149","volume":"8","author":"Wickham","year":"2017","journal-title":"J Adv Pract Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e91577","DOI":"10.1371\/journal.pone.0091577","volume":"9","author":"Lennon","year":"2014","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1002\/cncr.29460","volume":"121","author":"Singleton","year":"2015","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1007\/s00520-018-4062-z","volume":"26","author":"Zylla","year":"2018","journal-title":"Support Care Cancer"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1007\/s00520-014-2173-8","volume":"22","author":"Lee","year":"2014","journal-title":"Support Care Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"7417","DOI":"10.1200\/JCO.2005.09.158","volume":"23","author":"Brown","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref15","unstructured":"Salix Pharmaceuticals. Relistor [Package Insert]. Bridgewater, NJ: Salix Pharmaceuticals; 2020."},{"key":"ref16","first-page":"39","volume":"7","author":"Slatkin","year":"2009","journal-title":"J Support Oncol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1056\/NEJMoa0707377","volume":"358","author":"Thomas","year":"2008","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0009-9236(96)90117-4","volume":"59","author":"Yuan","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.2147\/JPR.S312731","volume":"14","author":"Chamberlain","year":"2021","journal-title":"J Pain Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1089\/jpm.2014.0362","volume":"18","author":"Bull","year":"2015","journal-title":"J Palliat Med"},{"key":"ref21","unstructured":"Rome IV criteria; 2016. Available from: https:\/\/theromefoundation.org\/rome-iv\/rome-iv-criteria\/. Accessed: February 9, 2022."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2217\/pmt-2019-0045","volume":"10","author":"Chamberlain","year":"2020","journal-title":"Pain Manag"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1097\/j.pain.0000000000001629","volume":"160","author":"Wild","year":"2019","journal-title":"Pain"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/annonc\/mdy118","volume":"29","author":"Katakami","year":"2018","journal-title":"Ann Oncol"},{"key":"ref25","unstructured":"AstraZeneca Pharmaceuticals. Movantik [Package Insert]. Wilmington, DE: AstraZeneca Pharmaceuticals; 2020."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1056\/NEJMoa1310246","volume":"370","author":"Chey","year":"2014","journal-title":"N Engl J Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/papr.12535","volume":"17","author":"Rauck","year":"2017","journal-title":"Pain Pract"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jpainsymman.2013.10.018","volume":"48","author":"Bartz","year":"2014","journal-title":"J Pain Symptom Manage"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jemermed.2021.10.012","volume":"62","author":"Peacock","year":"2022","journal-title":"J Emerg Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S2468-1253(17)30105-X","volume":"2","author":"Hale","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/920509","author":"Arshad","year":"2010","journal-title":"Patholog Res Int"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1002\/ijc.30252","volume":"139","author":"Wardill","year":"2016","journal-title":"Int J Cancer"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"23426","DOI":"10.18632\/oncotarget.25193","volume":"9","author":"Branca","year":"2018","journal-title":"Oncotarget"},{"key":"ref34","unstructured":"World Health Organization. Cancer Pain Relief: With a Guide to Opioid Availability. 2nd ed. Geneva, Switzerland: World Health Organization; 1996."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/1049909106289068","volume":"23","author":"Glare","year":"2006","journal-title":"Am J Hosp Palliat Care"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1007\/s00520-021-06070-7","volume":"29","author":"Brenner","year":"2021","journal-title":"Support Care Cancer"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.jpainsymman.2011.02.015","volume":"42","author":"Slatkin","year":"2011","journal-title":"J Pain Symptom Manage"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=91545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=91545","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T03:50:49Z","timestamp":1690429849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/methylnaltrexone-treatment-for-opioid-induced-constipation-in-patients-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":37,"URL":"https:\/\/doi.org\/10.2147\/jpr.s405825","relation":{},"ISSN":["1178-7090"],"issn-type":[{"type":"electronic","value":"1178-7090"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}