{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:47:16Z","timestamp":1776797236216,"version":"3.51.2"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s424086","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T02:10:13Z","timestamp":1702865413000},"page":"4317-4328","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Potential of Downregulated Interleukin-6 Signaling for the Treatment of Chronic Pain: A Mendelian Randomization Study"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Yaodan","family":"Bi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/papr.12050","volume":"14","author":"Andrew","year":"2014","journal-title":"Pain Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e328","DOI":"10.1097\/j.pain.0000000000002291","volume":"163","author":"Yong","year":"2022","journal-title":"Pain"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jamda.2020.02.011","volume":"21","author":"Hirase","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bja.2023.02.036","volume":"130","author":"Karimi","year":"2023","journal-title":"Br J Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","volume":"131","author":"Attal","year":"2023","journal-title":"Br J Anaesth"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13018-023-03567-1","volume":"18","author":"Tsuji","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/jcm12010011","volume":"12","author":"Kim","year":"2022","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1007\/s00586-023-07717-1","volume":"32","author":"Pinto","year":"2023","journal-title":"Eur Spine J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"Cd014682","DOI":"10.1002\/14651858.CD014682.pub2","volume":"5","author":"Birkinshaw","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/2327-6924.12155","volume":"27","author":"Falope","year":"2015","journal-title":"J Am Assoc Nurse Pract"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.7326\/0003-4819-147-7-200710020-00008","volume":"147","author":"Chou","year":"2007","journal-title":"Ann Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.nbd.2016.03.025","volume":"97","author":"Kelleher","year":"2017","journal-title":"Neurobiol Dis"},{"key":"ref13","first-page":"10","volume":"2018","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"155690","DOI":"10.1016\/j.cyto.2021.155690","volume":"148","author":"Rose-John","year":"2021","journal-title":"Cytokine"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1533-2500.2009.00301.x","volume":"9","author":"Ko\u00e7er","year":"2009","journal-title":"Pain Pract"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/jir.1996.16.695","volume":"16","author":"DeLeo","year":"1996","journal-title":"J Interferon Cytokine Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/jrsm.1346","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e023277","DOI":"10.1161\/JAHA.121.023277","volume":"11","author":"Georgakis","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/s41380-019-0395-3","volume":"25","author":"Khandaker","year":"2020","journal-title":"Mol Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1001\/jamapsychiatry.2020.3436","volume":"78","author":"Kappelmann","year":"2021","journal-title":"JAMA Psych"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e1004174","DOI":"10.1371\/journal.pmed.1004174","volume":"20","author":"Hamilton","year":"2023","journal-title":"PLoS Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41525-019-0097-4","volume":"4","author":"Rosa","year":"2019","journal-title":"NPJ Genom Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.ajhg.2018.09.009","volume":"103","author":"Ligthart","year":"2018","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/oby.2007.28","volume":"16","author":"Gottardo","year":"2008","journal-title":"Obesity"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1396398","DOI":"10.1155\/2017\/1396398","volume":"2017","author":"Morieri","year":"2017","journal-title":"Mediators Inflamm"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nature Genetics"},{"key":"ref30","first-page":"12","volume":"2021","author":"Hong","year":"2021","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e002872","DOI":"10.1161\/CIRCGEN.119.002872","volume":"13","author":"Georgakis","year":"2020","journal-title":"Circulation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"d548","DOI":"10.1136\/bmj.d548","volume":"342","author":"Wensley","year":"2011","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"6762","DOI":"10.1074\/jbc.RA117.001163","volume":"293","author":"Baran","year":"2018","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"eabn7082","DOI":"10.1126\/scisignal.abn7082","volume":"15","author":"Liao","year":"2022","journal-title":"Sci Signal"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.2147\/JPR.S365187","volume":"15","author":"Norman","year":"2022","journal-title":"J Pain Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1093\/pm\/pnac091","volume":"23","author":"Canl\u0131","year":"2022","journal-title":"Pain Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1002\/art.34384","volume":"64","author":"Vazquez","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00586-012-2183-5","volume":"21","author":"Ohtori","year":"2012","journal-title":"Eur Spine J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.2147\/JPR.S387502","volume":"15","author":"Blichfeldt-Eckhardt","year":"2022","journal-title":"J Pain Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/ijerph20010019","volume":"20","author":"Zwiri","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/scd.12757","volume":"43","author":"Campello","year":"2023","journal-title":"Spec Care Dentist"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40744-018-0102-x","volume":"5","author":"Rubbert-Roth","year":"2018","journal-title":"Rheumatol Ther"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/ajcn.115.118216","volume":"103","author":"Haycock","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1111\/bcp.15191","volume":"88","author":"Cupido","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"ref45","first-page":"52","volume":"2023","author":"Mourtzi","year":"2023","journal-title":"Age Ageing"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1154746","DOI":"10.3389\/fimmu.2023.1154746","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1136\/gutjnl-2017-314562","volume":"68","author":"Danese","year":"2019","journal-title":"Gut"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1053\/j.gastro.2018.05.022","volume":"155","author":"Parisinos","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95328","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T02:10:18Z","timestamp":1702865418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/therapeutic-potential-of-downregulated-interleukin-6-signaling-for-the-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/jpr.s424086","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}