{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:31:57Z","timestamp":1775277117920,"version":"3.50.1"},"reference-count":62,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s516682","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T01:34:28Z","timestamp":1752111268000},"page":"3463-3476","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Wangnan","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/bmb\/ldaa005","volume":"133","author":"Clynes","year":"2020","journal-title":"Br Med Bull"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/j.spinee.2021.03.008","volume":"21","author":"Ahern","year":"2021","journal-title":"Spine J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1097\/ogx.0000000000001181","volume":"78","author":"Rentzeperi","year":"2023","journal-title":"Obstet Gynecol Surv"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/ageing\/afj045","volume":"35","author":"Bainbridge","year":"2006","journal-title":"Age Ageing"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11657-022-01061-5","volume":"17","author":"Gregson","year":"2022","journal-title":"Arch Osteoporos"},{"key":"ref6","unstructured":"Kuo DT, Tadi P. Cervical spondylosis. 2024."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"m791","DOI":"10.1136\/bmj.m791","volume":"368","author":"Safiri","year":"2020","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ocl.2022.05.007","volume":"53","author":"Williams","year":"2022","journal-title":"Orthop Clin North Am"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.920167","volume":"13","author":"Liang","year":"2022","journal-title":"Front Endocrinol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1298531","volume":"15","author":"Liu","year":"2024","journal-title":"Front Endocrinol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/s00223-023-01165-1","volume":"114","author":"Zhao","year":"2024","journal-title":"Calcif Tissue Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1097\/BRS.0b013e31826cac62","volume":"37","author":"Lee","year":"2012","journal-title":"Spine"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00586-005-0954-y","volume":"15","author":"Kettler","year":"2006","journal-title":"Eur Spine J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e0257735","DOI":"10.1371\/journal.pone.0257735","volume":"16","author":"Hong","year":"2021","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/jor.23195","volume":"34","author":"Vo","year":"2016","journal-title":"J Orthop Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10143-003-0259-8","volume":"26","author":"Turgut","year":"2003","journal-title":"Neurosurg Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.mehy.2013.01.030","volume":"80","author":"Mattei","year":"2013","journal-title":"Med Hypotheses"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.5114\/reum\/194107","volume":"62","author":"\u017buchowski","year":"2024","journal-title":"Reumatologia"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/os.14310","volume":"17","author":"Chen","year":"2025","journal-title":"Orthop Surg"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41413-021-00156-y","volume":"9","author":"Kague","year":"2021","journal-title":"Bone Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12891-018-2055-1","volume":"19","author":"Wada","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrcardio.2017.78","volume":"14","author":"Holmes","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0962280210394459","volume":"21","author":"Palmer","year":"2012","journal-title":"Stat Methods Med Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41467-019-14156-4","volume":"11","author":"Burgess","year":"2020","journal-title":"Nat Commun"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1074574","volume":"14","author":"Hou","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1002\/oby.22604","volume":"27","author":"Kammire","year":"2019","journal-title":"Obesity"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/jbmr.3063","volume":"32","author":"Ahmad","year":"2017","journal-title":"J Bone Miner Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.tjog.2020.03.029","volume":"59","author":"Huang","year":"2020","journal-title":"Taiwan J Obstet Gynecol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature14878","volume":"526","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41588-018-0302-x","volume":"51","author":"Morris","year":"2019","journal-title":"Nat Genet"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ajhg.2017.12.005","volume":"102","author":"Medina-Gomez","year":"2018","journal-title":"Am J Hum Genet"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"a040501","DOI":"10.1101\/cshperspect.a040501","volume":"12","author":"Richmond","year":"2022","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1093\/ije\/dyy101","volume":"47","author":"Bowden","year":"2018","journal-title":"Int J Epidemiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum Mol Genet"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/ije\/dyy258","volume":"48","author":"Bowden","year":"2019","journal-title":"Int J Epidemiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/bmsp.12263","volume":"75","author":"Bakbergenuly","year":"2022","journal-title":"Br J Math Stat Psychol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/s41588-018-0164-2","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"g6284","DOI":"10.1136\/bmj.g6284","volume":"349","author":"Sedgwick","year":"2014","journal-title":"BMJ"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1284594","volume":"12","author":"Qiu","year":"2024","journal-title":"Front Public Health"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1056\/NEJMra2003558","volume":"383","author":"Theodore","year":"2020","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1080091","volume":"14","author":"Mello","year":"2023","journal-title":"Front Physiol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1016\/j.joms.2010.06.196","volume":"68","author":"Susarla","year":"2010","journal-title":"J Oral Maxillofacial Surg"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jbmr.476","volume":"26","author":"Wang","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1136\/ard.2010.131441","volume":"69","author":"Livshits","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1432; authorreply1433","DOI":"10.1002\/jbmr.1626","volume":"27","author":"Adams","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s00586-008-0645-6","volume":"17","author":"Rajasekaran","year":"2008","journal-title":"Eur Spine J"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1097\/BRS.0b013e318158cd69","volume":"32","author":"Gruber","year":"2007","journal-title":"Spine"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1007\/s10439-017-1914-5","volume":"45","author":"Rezaei","year":"2017","journal-title":"Ann Biomed Eng"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.acra.2017.06.013","volume":"24","author":"Mao","year":"2017","journal-title":"Acad Radiol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.spinee.2009.05.002","volume":"9","author":"Allen","year":"2009","journal-title":"Spine J"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/895474","volume":"2013","author":"Li","year":"2013","journal-title":"Int J Endocrinol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.spinee.2019.10.018","volume":"20","author":"Ehresman","year":"2020","journal-title":"Spine J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/os.13931","volume":"16","author":"Li","year":"2024","journal-title":"Orthop Surg"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1227\/neu.0000000000002269","volume":"92","author":"Soliman","year":"2023","journal-title":"Neurosurgery"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-016-0123-2","volume":"16","author":"Grams","year":"2016","journal-title":"BMC Med Imaging"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00256-023-04419-z","volume":"53","author":"W\u00e1ng","year":"2024","journal-title":"Skeletal Radiol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1093\/rheumatology\/keab007","volume":"60","author":"Zhao","year":"2021","journal-title":"Rheumatology"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1186\/s12891-024-07631-7","volume":"25","author":"Li","year":"2024","journal-title":"BMC Musculoskelet Disord"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00586-022-07484-5","volume":"32","author":"Razzouk","year":"2023","journal-title":"Eur Spine J"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104645","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T01:34:30Z","timestamp":1752111270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/exploring-causality-between-bone-mineral-density-and-cervical-spondylo-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"URL":"https:\/\/doi.org\/10.2147\/jpr.s516682","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}