{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:17:36Z","timestamp":1769548656771,"version":"3.49.0"},"reference-count":66,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s550889","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:25:10Z","timestamp":1769502310000},"page":"1-16","source":"Crossref","is-referenced-by-count":0,"title":["In vitro Effects of Gadoteric Acid and Iobitridol Toxicity and Platelet-Rich Plasma-Mediated Protection in Human Annulus Fibrosus and Nucleus Pulposus Cells"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Jon","family":"Mercader-Ruiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mariju\u00e1n-Pinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9422-8100","authenticated-orcid":true,"given":"Carlos","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maider","family":"Beitia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Fiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-0804","authenticated-orcid":true,"given":"Diego","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-6927","authenticated-orcid":true,"given":"Mikel","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3390\/ma12020253","volume":"12","author":"Frost","year":"2019","journal-title":"Materials"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1002\/art.34347","volume":"64","author":"Hoy","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1089\/107632703768247368","volume":"9","author":"Hunter","year":"2003","journal-title":"Tissue Eng"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"841831","DOI":"10.3389\/fcell.2022.841831","volume":"10","author":"Hickman","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1097\/BRS.0b013e3181b723c9","volume":"34","author":"Omlor","year":"2009","journal-title":"Spine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.spinee.2013.03.021","volume":"13","author":"Eder","year":"2013","journal-title":"Spine J Off J North Am Spine Soc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.ejrad.2016.10.013","volume":"85","author":"Seithe","year":"2016","journal-title":"Eur J Radiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s40261-013-0055-3","volume":"33","author":"McCormack","year":"2013","journal-title":"Clin Drug Investig"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10334-023-01113-y","volume":"37","author":"Parillo","year":"2024","journal-title":"Magma N Y N"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1007\/s00247-015-3394-9","volume":"45","author":"Balassy","year":"2015","journal-title":"Pediatr Radiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0720-048x(95)00611-s","volume":"20","author":"Taylor","year":"1995","journal-title":"Eur J Radiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4764348","DOI":"10.1155\/2021\/4764348","volume":"2021","author":"Moon","year":"2021","journal-title":"Contrast Media Mol Imaging"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12880-021-00600-9","volume":"21","author":"Jakobsen","year":"2021","journal-title":"BMC Med Imaging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.3390\/diagnostics14222487","volume":"14","author":"Shin","year":"2024","journal-title":"Diagnostics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ejrad.2010.03.018","volume":"80","author":"Maurer","year":"2011","journal-title":"Eur J Radiol"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Which iodinated contrast media is the least cytotoxic to human disc cells? | request PDF. Research Gate. 2024. doi:10.1016\/j.spinee.2015.01.015","DOI":"10.1016\/j.spinee.2015.01.015"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/00004424-199807000-00003","volume":"33","author":"Wasaki","year":"1998","journal-title":"Invest Radiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13018-017-0600-5","volume":"12","author":"Oznam","year":"2017","journal-title":"J Orthop Surg"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1038\/s41598-025-88918-0","volume":"15","author":"S\u00e1nchez","year":"2025","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"394632017747500","DOI":"10.1177\/0394632017747500","volume":"31","author":"Wu","year":"2018","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1080\/08923973.2023.2232106","volume":"45","author":"Hu","year":"2023","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00586-014-3198-x","volume":"23","author":"Pirvu","year":"2014","journal-title":"Eur Spine J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1097\/01.brs.0000214942.78119.24","volume":"31","author":"Akeda","year":"2006","journal-title":"Spine"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8893819","DOI":"10.1155\/2020\/8893819","volume":"2020","author":"Chang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"7677","DOI":"10.3390\/ijms24087677","volume":"24","author":"Kawabata","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1177\/0363546516664161","volume":"45","author":"Durant","year":"2017","journal-title":"Am J Sports Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.arthro.2013.04.006","volume":"29","author":"Beitzel","year":"2013","journal-title":"Arthrosc J Arthrosc Relat Surg Off Publ Arthrosc Assoc N Am Int Arthrosc Assoc"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.arthro.2011.09.013","volume":"28","author":"Carofino","year":"2012","journal-title":"Arthrosc J Arthrosc Relat Surg Off Publ Arthrosc Assoc N Am Int Arthrosc Assoc"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2325967115590968","DOI":"10.1177\/2325967115590968","volume":"3","author":"Muto","year":"2015","journal-title":"Orthop J Sports Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1177\/0363546516681294","volume":"45","author":"Jo","year":"2017","journal-title":"Am J Sports Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.spinee.2013.06.095","volume":"14","author":"Chee","year":"2014","journal-title":"Spine J off J North Am Spine Soc"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"13811","DOI":"10.3390\/ijms241813811","volume":"24","author":"Mercader Ruiz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref34","volume-title":"Assay Guidance Manual","year":"2004"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14712598.2020.1798925","volume":"20","author":"Kon","year":"2020","journal-title":"Expert Opin Biol Ther"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1582623","author":"Gradisnik","year":"2024","journal-title":"ResearchGate"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e92442","DOI":"10.1371\/journal.pone.0092442","volume":"9","author":"Iwasaki","year":"2014","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3346\/jkms.2013.28.12.1703","volume":"28","author":"Seong","year":"2013","journal-title":"J Korean Med Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.spinee.2015.01.015","volume":"15","author":"Kim","year":"2015","journal-title":"Spine J off J North Am Spine Soc"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/RLI.0000000000000567","volume":"54","author":"Bower","year":"2019","journal-title":"Invest Radiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00234-020-02434-8","volume":"62","author":"Mallio","year":"2020","journal-title":"Neuroradiology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.3390\/ijms25074071","volume":"25","author":"Coimbra","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10534-016-9931-7","volume":"29","author":"Rogosnitzky","year":"2016","journal-title":"Biometals Int J Role Met Ions Biol Biochem Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s40263-018-0500-1","volume":"32","author":"Pasquini","year":"2018","journal-title":"CNS Drugs"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"561","DOI":"10.34067\/kid.0000272019","volume":"1","author":"Do","year":"2020","journal-title":"Kidney360"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1136\/ard.2010.134858","volume":"69","author":"Galdo","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1471-4159.2010.07162.x","volume":"117","author":"Xia","year":"2011","journal-title":"J Neurochem"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/jor.22532","volume":"32","author":"Kim","year":"2014","journal-title":"J Orthop Res off Publ Orthop Res Soc"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/SHK.0000000000001947","volume":"58","author":"Hu","year":"2022","journal-title":"Shock Augusta Ga"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fendo.2023.1138255","author":"Wang","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.12659\/MSM.892510","volume":"21","author":"Gui","year":"2015","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pmrj.2015.08.010","volume":"8","author":"Tuakli-Wosornu","year":"2016","journal-title":"PM R"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3892\/ijmm.2013.1586","volume":"33","author":"Zhang","year":"2014","journal-title":"Int J Mol Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3892\/mmr.2012.1238","volume":"7","author":"Zhang","year":"2013","journal-title":"Mol Med Rep"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"5886","DOI":"10.26355\/eurrev_202006_21481","volume":"24","author":"Chen","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref56","unstructured":"Expression of carbonic anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death - PubMed. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29559661\/. Accessed December 27, 2024."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/jor.24679","volume":"39","author":"Itsuji","year":"2021","journal-title":"J Orthop Res Off Publ Orthop Res Soc"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"8717","DOI":"10.3390\/ijms21228717","volume":"21","author":"Tonomura","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref59","unstructured":"Effects of TGF-beta1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations - PubMed. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/17150129\/. Accessed December 27, 2024."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.7150\/thno.33638","volume":"9","author":"Liao","year":"2019","journal-title":"Theranostics"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/jcmm.13316","volume":"22","author":"Cheng","year":"2018","journal-title":"J Cell Mol Med"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.922928","volume":"26","author":"Li","year":"2020","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.07.026","volume":"143","author":"Xia","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.19540\/j.cnki.cjcmm.20230601.703","volume":"48","author":"Yang","year":"2023","journal-title":"Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J Chin Mater Medica"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/jor.24880","volume":"39","author":"Zhang","year":"2021","journal-title":"J Orthop Res off Publ Orthop Res Soc"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1080\/15384101.2021.1949839","volume":"20","author":"Xu","year":"2021","journal-title":"Cell Cycle Georget Tex"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111356","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:25:15Z","timestamp":1769502315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/in-vitro-effects-of-gadoteric-acid-and-iobitridol-toxicity-and-platele-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":66,"URL":"https:\/\/doi.org\/10.2147\/jpr.s550889","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}