{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:23:52Z","timestamp":1775478232975,"version":"3.50.1"},"reference-count":33,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s580694","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:10:11Z","timestamp":1772449811000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["The Efficacy and Safety of Crisugabalin (HSK16149) in Fibromyalgia Patients: Protocol for a Prospective Randomized Open Blinded-Endpoint (PROBE) Study"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Minying","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huacheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunwu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bifa","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-2276","authenticated-orcid":true,"given":"Shuiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-0355","authenticated-orcid":true,"given":"Fang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/art.38905","volume":"67","author":"Jones","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/ar2715","volume":"11","author":"Spaeth","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12891-016-1027-6","volume":"17","author":"Lacasse","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrrheum.2011.98","volume":"7","author":"Schmidt-Wilcke","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref8","first-page":"CD010782","volume":"2013","author":"\u00dc\u00e7eyler","year":"1996","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"CD010567","DOI":"10.1002\/14651858.CD010567.pub2","volume":"2013","author":"Wiffen","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1001\/jama.2008.944","volume":"301","author":"H\u00e4user","year":"2009","journal-title":"JAMA"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"CD010292","DOI":"10.1002\/14651858.CD010292.pub2","volume":"2","author":"Welsch","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/art.20076","volume":"51","author":"Tofferi","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1212\/WNL.0000000000011424","volume":"96","author":"Benarroch","year":"2021","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1001\/jamainternmed.2019.0086","volume":"179","author":"Goodman","year":"2019","journal-title":"JAMA Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"CD011790","DOI":"10.1002\/14651858.CD011790.pub2","volume":"9","author":"Derry","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/14737175.2018.1508344","volume":"18","author":"Alciati","year":"2018","journal-title":"Expert Rev Neurother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/rheumatology\/kep432","volume":"49","author":"Straube","year":"2010","journal-title":"Rheumatology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"m1315","DOI":"10.1136\/bmj.m1315","volume":"369","author":"Mathieson","year":"2020","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1124\/jpet.120.000315","volume":"376","author":"Gou","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e2425614","DOI":"10.1001\/jamanetworkopen.2024.25614","volume":"7","author":"Guo","year":"2024","journal-title":"JAMA Network Open"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1001\/jamadermatol.2024.3410","volume":"160","author":"Zhang","year":"2024","journal-title":"JAMA Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1296672","DOI":"10.3389\/fphar.2023.1296672","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.2147\/JPR.S274562","volume":"13","author":"Arnold","year":"2020","journal-title":"J Pain Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/1759720X13483894","volume":"5","author":"Mease","year":"2013","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"R120","DOI":"10.1186\/ar2783","volume":"11","author":"Bennett","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jphys.2015.07.001","volume":"62","author":"Poquet","year":"2016","journal-title":"J Physiother"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1136\/bmj.306.6890.1437","volume":"306","author":"Jenkinson","year":"1993","journal-title":"BMJ"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e000146","DOI":"10.1136\/rmdopen-2015-000146","volume":"1","author":"Rampakakis","year":"2015","journal-title":"RMD Open"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.sleep.2004.07.006","volume":"6","author":"Hays","year":"2005","journal-title":"Sleep Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000066239","volume":"31","author":"Richter","year":"1998","journal-title":"Psychopathology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1097\/j.pain.0000000000002875","volume":"164","author":"Gilron","year":"2023","journal-title":"Pain"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3899\/jrheum.141196","volume":"42","author":"Arnold","year":"2015","journal-title":"J Rheumatol"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/112561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/112561","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:10:12Z","timestamp":1772449812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-efficacy-and-safety-of-crisugabalin-hsk16149-in-fibromyalgia-patie-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"URL":"https:\/\/doi.org\/10.2147\/jpr.s580694","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}