{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:27:54Z","timestamp":1791912474596,"version":"4.3.4"},"reference-count":95,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NDT"],"DOI":"10.2147\/ndt.s374694","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T04:15:12Z","timestamp":1701404112000},"page":"2639-2655","source":"Crossref","is-referenced-by-count":27,"title":["Ravulizumab in Myasthenia Gravis: A Review of the Current Evidence"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Tuan","family":"Vu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Reddel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Howard Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.3390\/jcm10112235","volume":"10","author":"Dresser","year":"2021","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1056\/nejmra1602678","volume":"375","author":"Gilhus","year":"2016","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/nyas.13522","volume":"1412","author":"Howard","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00415-016-8045-z","volume":"263","author":"Melzer","year":"2016","journal-title":"J Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1600-0404.1988.tb06970.x","volume":"77","author":"Evoli","year":"1988","journal-title":"Acta Neurol Scand"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s40120-022-00408-x","volume":"12","author":"Jackson","year":"2023","journal-title":"Neurol Ther"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e00538","DOI":"10.1002\/brb3.538","volume":"6","author":"Hoffmann","year":"2016","journal-title":"Brain Behav"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1007\/s11136-019-02148-2","volume":"28","author":"Andersen","year":"2019","journal-title":"Qual Life Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/mus.26069","volume":"58","author":"Tran","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/mus.27832","volume":"68","author":"Claytor","year":"2023","journal-title":"Muscle Nerve"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/ene.13836","volume":"26","author":"Barnett","year":"2019","journal-title":"Eur J Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/mus.26695","volume":"60","author":"Cutter","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12883-016-0757-2","volume":"16","author":"Frost","year":"2016","journal-title":"BMC Neurol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e013278","DOI":"10.1136\/bmjopen-2016-013278","volume":"7","author":"Nagane","year":"2017","journal-title":"BMJ Open"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1477-7525-8-129","volume":"8","author":"Twork","year":"2010","journal-title":"Health Qual Life Outcomes"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"19275","DOI":"10.1038\/s41598-022-22078-3","volume":"12","author":"Marbin","year":"2022","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s12883-019-1573-2","volume":"19","author":"Bacci","year":"2019","journal-title":"BMC Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12974-022-02448-4","volume":"19","author":"Nelke","year":"2022","journal-title":"J Neuroinflammation"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/cnd.0b013e31822c34dd","volume":"13","author":"Heatwole","year":"2011","journal-title":"J Clin Neuromuscul Dis"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/13548506.2020.1807577","volume":"26","author":"Liu","year":"2021","journal-title":"Psychol Health Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2020.06.011","author":"Garc\u00eda Est\u00e9vez","year":"2020","journal-title":"Neurologia"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000487886","volume":"50","author":"Martinka","year":"2018","journal-title":"Neuroepidemiology"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/mus.27120","volume":"63","author":"Sanders","year":"2021","journal-title":"Muscle Nerve"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/mus.25068","volume":"54","author":"Santos","year":"2016","journal-title":"Muscle Nerve"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000512973","volume":"55","author":"Sobieszczuk","year":"2021","journal-title":"Neuroepidemiology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1002\/art.42330","volume":"74","author":"Dinse","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.bbadis.2014.11.022","volume":"1852","author":"Ha","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2147\/itt.s261414","volume":"9","author":"Mantegazza","year":"2020","journal-title":"Immunotargets Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.12688\/f1000research.8206.1","volume":"5","author":"Phillips","year":"2016","journal-title":"F1000Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/nyas.13592","volume":"1413","author":"Vincent","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3390\/biomedicines10061360","volume":"10","author":"Iacomino","year":"2022","journal-title":"Biomedicines"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e1169","DOI":"10.1212\/nxi.0000000000001169","volume":"9","author":"Obaid","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s00401-022-02493-6","volume":"144","author":"Rose","year":"2022","journal-title":"Acta Neuropathol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3389\/fimmu.2020.00917","volume":"11","author":"Albazli","year":"2020","journal-title":"Front Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/85520","volume":"7","author":"Hoch","year":"2001","journal-title":"Nat Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1196\/annals.1405.012","volume":"1132","author":"Evoli","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3389\/fneur.2020.00981","volume":"11","author":"Mantegazza","year":"2020","journal-title":"Front Neurol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/ana.20061","volume":"55","author":"McConville","year":"2004","journal-title":"Ann Neurol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1087532","DOI":"10.3389\/fimmu.2023.1087532","volume":"14","author":"Oskam","year":"2023","journal-title":"Front Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/ana.20341","volume":"57","author":"Shiraishi","year":"2005","journal-title":"Ann Neurol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1212\/wnl.0000000000002790","volume":"87","author":"Sanders","year":"2016","journal-title":"Neurology"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1212\/wnl.0000000000011124","volume":"96","author":"Narayanaswami","year":"2021","journal-title":"Neurology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3389\/fneur.2020.00538","volume":"11","author":"Menon","year":"2020","journal-title":"Front Neurol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"102712","DOI":"10.1016\/j.autrev.2020.102712","volume":"20","author":"Lascano","year":"2021","journal-title":"Autoimmun Rev"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1756286419832242","DOI":"10.1177\/1756286419832242","volume":"12","author":"Schneider-Gold","year":"2019","journal-title":"Ther Adv Neurol Disord"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s13311-015-0398-y","volume":"13","author":"Guptill","year":"2016","journal-title":"Neurotherapeutics"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/s1474-4422(17)30369-1","volume":"16","author":"Howard","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"EVIDoa2100066","DOI":"10.1056\/EVIDoa2100066","volume":"1","author":"Vu","year":"2022","journal-title":"NEJM Evid"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/s1474-4422(23)00080-7","volume":"22","author":"Howard","year":"2023","journal-title":"Lancet Neurol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s40265-022-01678-3","volume":"82","author":"Heo","year":"2022","journal-title":"Drugs"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/s1474-4422(21)00159-9","volume":"20","author":"Howard","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/s1474-4422(23)00077-7","volume":"22","author":"Bril","year":"2023","journal-title":"Lancet Neurol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1136\/jnnp-2019-322606","volume":"91","author":"Di Stefano","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e19416","DOI":"10.7759\/cureus.19416","volume":"13","author":"Bastakoti","year":"2021","journal-title":"Cureus"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e376","DOI":"10.1212\/wnl.0000000000013121","volume":"98","author":"Nowak","year":"2021","journal-title":"Neurology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/mus.23839","volume":"48","author":"Howard","year":"2013","journal-title":"Muscle Nerve"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/mus.26447","volume":"60","author":"Muppidi","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s00415-020-09770-y","volume":"267","author":"Vissing","year":"2020","journal-title":"J Neurol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e0195909","DOI":"10.1371\/journal.pone.0195909","volume":"13","author":"Sheridan","year":"2018","journal-title":"PLoS One"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e0230869","DOI":"10.1371\/journal.pone.0230869","volume":"15","author":"Alashkar","year":"2020","journal-title":"PLoS One"},{"key":"ref62","unstructured":"Alexion Pharmaceuticals Inc. ULTOMIRIS\u00ae (ravulizumab-cwvz) injection prescribing information; 2022. Available from: https:\/\/alexion.com\/Documents\/ultomiris_uspi. Accessed October 19, 2023."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1182\/blood-2018-09-876136","volume":"133","author":"Lee","year":"2019","journal-title":"Blood"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.kint.2020.01.035","volume":"97","author":"Rondeau","year":"2020","journal-title":"Kidney Int"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s00415-023-11617-1","volume":"270","author":"Vu","year":"2023","journal-title":"J Neurol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"696385","DOI":"10.3389\/fneur.2021.696385","volume":"12","author":"Monteleone","year":"2021","journal-title":"Front Neurol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1749-6632.2012.06817.x","volume":"1274","author":"Muppidi","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"106488","DOI":"10.1016\/j.clineuro.2021.106488","volume":"202","author":"Kalita","year":"2021","journal-title":"Clin Neurol Neurosurg"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"510","DOI":"10.4103\/aian.AIAN_551_20","volume":"23","author":"Stojanov","year":"2020","journal-title":"Ann Indian Acad Neurol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/mus.23988","volume":"49","author":"Katzberg","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/cen3.12738","volume":"14","author":"Uzawa","year":"2023","journal-title":"Clin Exp Neuroimmunol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/cen3.12738","volume":"14","author":"Suzuki","year":"2023","journal-title":"Clin Exp Neuroimmunol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1007\/s00415-023-11699-x","volume":"270","author":"Meisel","year":"2023","journal-title":"J Neurol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1002\/mus.27540","volume":"65","author":"Vu","year":"2022","journal-title":"Muscle Nerve"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/cen3.12738","volume":"14","author":"Vu","year":"2023","journal-title":"Clin Exp Neuroimmunol"},{"key":"ref76","unstructured":"AstraZeneca. Ultomiris demonstrated sustained improvements in functional activities and quality of life in adults with generalised myasthenia gravis through 60 weeks [press release]; 2022. Available from: https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2022\/ultomiris-demonstrated-sustained-improvements-functional-activities-quality-life-adults-generalised-myasthenia-gravis-60-weeks.html. Accessed October 19, 2023."},{"key":"ref77","unstructured":"Habib AA, Benatar M, Vu T, et al. Ravulizumab for the treatment of generalized myasthenia gravis: timing of response. Oral presentation at Myasthenia Gravis Foundation of America 2022 Scientific Session; 2022; Nashville, TN, USA."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/acn3.51376","volume":"8","author":"Howard","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"key":"ref79","first-page":"61","volume":"29","author":"Mantegazza","year":"2022","journal-title":"Eur J Neurol"},{"key":"ref80","unstructured":"Mantegazza R, Meisel A, Vu T, et al. Ravulizumab reduces clinical deteriorations in patients with generalized myasthenia gravis: results from the CHAMPION MG study [Poster no. 148]. Poster presented at Muscular Dystrophy Association Clinical & Scientific Conference; 2023; Dallas, TX, USA. Available from: https:\/\/www.mdaconference.org\/abstract-library\/ravulizumab-reduces-clinical-deteriorations-in-patients-with-generalized-myasthenia-gravis-results-from-The-champion-mg-study\/. Accessed October 19, 2023."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1212\/WNL.0000000000202156","volume":"100","author":"Muppidi","year":"2023","journal-title":"Neurology"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"802559","DOI":"10.3389\/fneur.2022.802559","volume":"13","author":"Kim","year":"2022","journal-title":"Front Neurol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/bjh.16711","volume":"191","author":"Peffault de Latour","year":"2020","journal-title":"Br J Haematol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1212\/wnl.0000000000011207","volume":"96","author":"Mantegazza","year":"2021","journal-title":"Neurology"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1182\/blood-2018-09-876805","volume":"133","author":"Kulasekararaj","year":"2019","journal-title":"Blood"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/ejh.13564","volume":"106","author":"Kulasekararaj","year":"2021","journal-title":"Eur J Haematol"},{"key":"ref87","unstructured":"Alexion Europe SAS. Ultomiris (ravulizumab) summary of product characteristics; 2023. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/ultomiris-epar-product-information_en.pdf. Accessed October 19, 2023."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000511957","volume":"13","author":"Vu","year":"2021","journal-title":"Case Rep Neurol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1056\/nejmoa1502950","volume":"373","author":"Kelly","year":"2015","journal-title":"N Engl J Med"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/1753495x211019899","volume":"15","author":"Manning","year":"2022","journal-title":"Obstet Med"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1097\/wco.0000000000001088","volume":"35","author":"Masi","year":"2022","journal-title":"Curr Opin Neurol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"118074","DOI":"10.1016\/j.jns.2021.118074","volume":"430","author":"Wolfe","year":"2021","journal-title":"J Neurol Sci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.1007\/s00415-022-11222-8","volume":"269","author":"Strano","year":"2022","journal-title":"J Neurol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1007\/s00415-021-10428-6","volume":"268","author":"Hofstadt-van Oy","year":"2021","journal-title":"J Neurol"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1007\/s10072-023-06900-y","volume":"44","author":"Vinciguerra","year":"2023","journal-title":"Neurol Sci"}],"container-title":["Neuropsychiatric Disease and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94830","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T04:15:19Z","timestamp":1701404119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/ravulizumab-in-myasthenia-gravis-a-review-of-the-current-evidence-peer-reviewed-fulltext-article-NDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":95,"URL":"https:\/\/doi.org\/10.2147\/ndt.s374694","relation":{},"ISSN":["1178-2021"],"issn-type":[{"value":"1178-2021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}