{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T23:37:31Z","timestamp":1768952251545,"version":"3.49.0"},"reference-count":35,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NDT"],"DOI":"10.2147\/ndt.s562758","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:30:11Z","timestamp":1768905011000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Flaxseed Supplementation Confers Resilience to Stress-Induced Depression-Like Behaviors via GDNF Epigenetic Modulation in the Ventral Tegmental Area of Rats"],"prefix":"10.2147","volume":"Volume 22","author":[{"given":"Qing","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongzhao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9833-433X","authenticated-orcid":true,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Depression and other common mental disorders: global health estimates (Internet). 2018. Geneva, Switzerland: World Health Organization. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/254610\/1\/WHO-MSD-MER-2017.2-eng.pdf?ua=1. Accessed 1, September 2018."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","volume":"391","author":"Cipriani","year":"2018","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41380-022-01824-z","volume":"28","author":"Kishi","year":"2023","journal-title":"Mol Psychiatry"},{"key":"ref4","first-page":"27","volume":"17","author":"Russo","year":"2012","journal-title":"Nat Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1126\/science.1222942","volume":"338","author":"Southwick","year":"2012","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.biopsych.2024.10.016","volume":"97","author":"Hermans","year":"2025","journal-title":"Biol Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s40001-023-01203-6","volume":"28","author":"Al-Madhagy","year":"2023","journal-title":"Eur J Med Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bbr.2018.05.021","volume":"351","author":"Steyn","year":"2018","journal-title":"Behav Brain Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e01626","DOI":"10.1002\/brb3.1626","volume":"10","author":"Han","year":"2020","journal-title":"Brain Behav"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/pcn.12100","volume":"67","author":"Naveen","year":"2013","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.plefa.2015.03.001","volume":"97","author":"Mucci Dde","year":"2015","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref12","first-page":"403","volume":"56","author":"Elkaoui","year":"2025","journal-title":"Egypt J Vet Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/s41380-021-01394-6","volume":"27","author":"Lindholm","year":"2022","journal-title":"Mol Psychiatry"},{"key":"ref14","first-page":"785","volume":"55","author":"Bagheri","year":"2017","journal-title":"Acta Med Iran"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.neuron.2010.12.023","volume":"69","author":"Uchida","year":"2011","journal-title":"Neuron"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3389\/fpsyt.2018.00732","volume":"9","author":"Zhang","year":"2019","journal-title":"Front Psychiatry"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12944-019-1120-6","volume":"18","author":"Gonz\u00e1lez-Becerra","year":"2019","journal-title":"Lipids Health Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12888-017-1335-x","volume":"17","author":"Zhang","year":"2017","journal-title":"BMC Psychiatry"},{"key":"ref20","volume-title":"The Rat Brain in Stereotaxic Coordinates","year":"1998"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/sj.npp.1301101","volume":"32","author":"Zhang","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref22","first-page":"101","volume":"99","author":"Antoniuk","year":"2019","journal-title":"NeurosciBiobehav Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"149123","DOI":"10.1016\/j.brainres.2024.149123","volume":"1843","author":"Sharma","year":"2024","journal-title":"Brain Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","volume":"77","author":"Primo","year":"2023","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"106917","DOI":"10.1016\/j.phrs.2023.106917","volume":"196","author":"Brandwein","year":"2023","journal-title":"Pharmacol Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.psychres.2007.05.010","volume":"159","author":"Buckner","year":"2008","journal-title":"Psychiatry Res"},{"key":"ref27","volume-title":"Resilience: The Science of Mastering Life\u2019s Greatest Challenges","year":"2012"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1038\/npp.2013.62","volume":"9","author":"Ho","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41380-018-0127-0","volume":"24","author":"Ji","year":"2019","journal-title":"Mol Psychiatry"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1476-511X-3-25","volume":"3","author":"Logan","year":"2004","journal-title":"Lipids Health Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1126\/science.1249240","volume":"344","author":"Friedman","year":"2014","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3171\/jns.2000.92.5.0863","volume":"92","author":"Mendez","year":"2000","journal-title":"J Neurosurg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/nu11051171","volume":"11","author":"Parikh","year":"2019","journal-title":"Nutrients"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.plefa.2006.07.005","volume":"75","author":"Chalon","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3389\/fgene.2018.00641","volume":"9","author":"Kezimana","year":"2018","journal-title":"Front Genet"}],"container-title":["Neuropsychiatric Disease and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111144","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:30:14Z","timestamp":1768905014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/flaxseed-supplementation-confers-resilience-to-stress-induced-depressi-peer-reviewed-fulltext-article-NDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"URL":"https:\/\/doi.org\/10.2147\/ndt.s562758","relation":{},"ISSN":["1178-2021"],"issn-type":[{"value":"1178-2021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}