{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:03:30Z","timestamp":1777953810060,"version":"3.51.4"},"reference-count":67,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NDT"],"DOI":"10.2147\/ndt.s595606","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:55:12Z","timestamp":1777913712000},"page":"1-27","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Escitalopram for Major Depressive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis with Age-Specific Findings"],"prefix":"10.2147","volume":"Volume 22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6125-6489","authenticated-orcid":true,"given":"\u0e3aBenchalak","family":"Maneeton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-6720","authenticated-orcid":true,"given":"Narong","family":"Maneeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichaya","family":"Pojanapotha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1138-6124","authenticated-orcid":true,"given":"Suwannee","family":"Putthisri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awirut","family":"Oon-arom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-0991","authenticated-orcid":true,"given":"Nuntaporn","family":"Karawekpanyawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suttipong","family":"Kawilapat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapinpatch","family":"Maneeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6753-6470","authenticated-orcid":true,"given":"Kamolrawee","family":"Srichan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.9740\/mhc.2018.11.275","volume":"8","author":"Mullen","year":"2018","journal-title":"Ment Health Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jaac.2014.10.010","volume":"54","author":"Avenevoli","year":"2015","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1089\/cap.2008.032","volume":"18","author":"Daviss","year":"2008","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.31887\/DCNS.2015.17.2\/jflory","volume":"17","author":"Flory","year":"2015","journal-title":"Dialogues Clin Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jad.2013.10.002","volume":"152","author":"Ghio","year":"2014","journal-title":"J Affect Disord"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e0185119","DOI":"10.1371\/journal.pone.0185119","volume":"12","author":"Hung","year":"2017","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e20161878","DOI":"10.1542\/peds.2016-1878","volume":"138","author":"Mojtabai","year":"2016","journal-title":"Pediatrics"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0272-7358(98)00010-5","volume":"18","author":"Lewinsohn","year":"1998","journal-title":"Clin Psychol Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1001\/archpsyc.59.3.225","volume":"59","author":"Fergusson","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/MOP.0b013e32833063e1","volume":"21","author":"Cash","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"ref11","unstructured":"Ministry of Public Health. Thai National Mental Health Survey 2023: Prevalence and Trends of Mental Disorders. Bangkok: Ministry of Public Health; 2024."},{"key":"ref12","unstructured":"National Health Security Office (NHSO); Department of Mental Health. Annual Report on Mental Health Statistics 2024: The Escalation of Depressive Disorders in the Thai Population. Bangkok: NHSO; 2025."},{"key":"ref13","unstructured":"ThaiHealth; Mahidol University. Thai Health Report 2025: Thai Youth Mental Health Crisis. Bangkok: ThaiHealth; 2025."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5430\/wje.v15n3p1","volume":"15","author":"Rungsang","year":"2025","journal-title":"World J Educ"},{"key":"ref15","unstructured":"Medical Council of Thailand. Workforce Distribution of Child and Adolescent Psychiatrists in Thailand: 2024 Update. Bangkok: Medical Council of Thailand; 2025."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"h824","DOI":"10.1136\/bmj.h824","volume":"350","author":"Hopkins","year":"2015","journal-title":"BMJ"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1136\/bjsports-2015-h824rep","volume":"50","author":"Hopkins","year":"2016","journal-title":"Br J Sports Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s11920-013-0381-4","volume":"15","author":"Cheung","year":"2013","journal-title":"Curr Psychiatry Rep"},{"key":"ref19","first-page":"1367","volume":"83","author":"Maneeton","year":"2000","journal-title":"J Med Assoc Thai"},{"key":"ref20","unstructured":"Food and Drug Administration. Fluoxetine Hydrochloride: Highlights of Prescribing Information. Silver Spring, MD: FDA; 2023."},{"key":"ref21","unstructured":"National Institute for Health and Care Excellence. Depression in Children and Young People: Identification and Management. NICE Guideline NG134. London: NICE; 2024."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"CD013674","DOI":"10.1002\/14651858.CD013674.pub2","volume":"5","author":"Hetrick","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0140-6736(16)30385-3","volume":"388","author":"Cipriani","year":"2016","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1177\/0018578720925384","volume":"56","author":"Reyad","year":"2021","journal-title":"Hosp Pharm"},{"key":"ref25","first-page":"315","volume":"20","author":"Carandang","year":"2011","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1097\/chi.0b013e31804a859b","volume":"46","author":"Hughes","year":"2007","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/01.chi.0000192250.38400.9e","volume":"45","author":"Wagner","year":"2006","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1097\/CHI.0b013e3181a2b304","volume":"48","author":"Emslie","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1089\/cap.2023.0048","volume":"33","author":"Saito","year":"2023","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1176\/appi.ajp.2008.08020247","volume":"166","author":"Bridge","year":"2009","journal-title":"Am J Psychiatry"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref32","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. Version 6.5 (Updated August 2024). Cochrane","year":"2024"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/S0140-6736(09)60046-5","volume":"373","author":"Cipriani","year":"2009","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1177\/0269881107083808","volume":"22","author":"Papakostas","year":"2008","journal-title":"J Psychopharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jclinepi.2005.08.017","volume":"59","author":"Wiebe","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/s0013-7006(04)95427-9","volume":"30","author":"Azorin","year":"2004","journal-title":"Encephale"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1345\/aph.1k089","volume":"41","author":"Baldwin","year":"2007","journal-title":"Ann Pharmacother"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1185\/030079907x210732","volume":"23","author":"Wade","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2165\/11204340-000000000-00000","volume":"12","author":"Yang","year":"2010","journal-title":"Paediatr Drugs"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1517\/14656566.2011.604632","volume":"12","author":"Ahn","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.encep.2011.11.003","volume":"38","author":"Favr\u00e9","year":"2012","journal-title":"Encephale"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1017\/S1092852913000060","volume":"18","author":"Demyttenaere","year":"2013","journal-title":"CNS Spectr"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3238\/arztebl.2013.0854","volume":"110","author":"Dolle","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12888-014-0340-6","volume":"14","author":"Zhou","year":"2014","journal-title":"BMC Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S2215-0366(20)30137-1","volume":"7","author":"Zhou","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1192\/bjo.2022.565","volume":"8","author":"Barba","year":"2022","journal-title":"BJPsych Open"},{"key":"ref48","unstructured":"Clinicaltrials. An open-label long-term study of escitalopram in children 7 to 11 years of age with major depressive disorder. ClinicalTrials.gov Identifier: NCT01198795. Available from: https:\/\/clinicaltrials.gov\/study\/NCT01198795. Accessed December 5, 2025."},{"key":"ref49","first-page":"364,366,368","volume":"105","author":"Pinto","year":"2007","journal-title":"J Indian Med Assoc"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1089\/cap.2012.0023","volume":"23","author":"Findling","year":"2013","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref51","unstructured":"WHO. Efficacy and safety of fecal microbiota transplantation combined with escitalopram in adolescents with mild-to-moderate depressive disorder and gastrointestinal symptoms. WHO International Clinical Trials Registry Platform. ChiCTR2500099096. Available from: https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=ChiCTR2500099096. Accessed December 5, 2025."},{"key":"ref52","unstructured":"Clinicaltrials. Pharmacogenetically-guided escitalopram treatment for pediatric anxiety: aiming to improve safety and efficacy (PrEcISE). ClinicalTrials.gov Identifier: NCT04623099. Available from: https:\/\/clinicaltrials.gov\/study\/NCT04623099. Accessed December 5, 2025."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1345\/aph.1C078","volume":"36","author":"Baumgartner","year":"2002","journal-title":"Ann Pharmacother"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12888-025-06624-7","volume":"25","author":"Xu","year":"2025","journal-title":"BMC Psychiatry"},{"key":"ref55","unstructured":"Mochida Pharmaceutical Co., Ltd. A phase 3 clinical trial of MLD-55 in pediatric patients with depression. Japan Registry of Clinical Trials. jRCT2080224520. Registered January 15, 2019. Available from: https:\/\/jrct.mhlw.go.jp\/en-latest-detail\/jRCT2080224520."},{"key":"ref56","unstructured":"Forest Laboratories. A double-blind flexible dose study of escitalopram in pediatric patients with major depressive disorder. ClinicalTrials.gov Identifier: NCT00107120. Registered April 5, 2005. Available from: https:\/\/clinicaltrials.gov\/study\/NCT00107120."},{"key":"ref57","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (Updated March 2011). The Cochrane Collaboration","year":"2009"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"CD006402","DOI":"10.1002\/14651858.MR000033.pub3","volume":"2","author":"Lundh","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"ref59","first-page":"2","volume":"44","author":"Yan","year":"2009","journal-title":"Psychiatr News"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/cap.2006.16.207","volume":"16","author":"Heiligenstein","year":"2006","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1097\/00004583-200210000-00010","volume":"41","author":"Emslie","year":"2002","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref62","first-page":"4","volume":"25","author":"Garland","year":"2016","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1001\/jama.292.7.807","volume":"292","author":"March","year":"2004","journal-title":"JAMA"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"103","DOI":"10.18332\/tid\/155333","volume":"20","author":"Patanavanich","year":"2022","journal-title":"Tob Induc Dis"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e2161","DOI":"10.1002\/nop2.2161","volume":"11","author":"Reangsing","year":"2024","journal-title":"Nurs Open"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"509","DOI":"10.34044\/j.kjss.2023.44.2.21","volume":"44","author":"Choychod","year":"2023","journal-title":"Kasetsart J Soc Sci"},{"key":"ref67","unstructured":"World Health Organization. Mental Health Atlas 2020. Geneva: World Health Organization; 2021."}],"container-title":["Neuropsychiatric Disease and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114822","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:55:17Z","timestamp":1777913717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/efficacy-and-safety-of-escitalopram-for-major-depressive-disorder-in-c-peer-reviewed-fulltext-article-NDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":67,"URL":"https:\/\/doi.org\/10.2147\/ndt.s595606","relation":{},"ISSN":["1178-2021"],"issn-type":[{"value":"1178-2021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}