{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:03:57Z","timestamp":1791745437317,"version":"4.3.4"},"reference-count":78,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NSA"],"DOI":"10.2147\/nsa.s596038","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:15:14Z","timestamp":1779207314000},"page":"1-19","source":"Crossref","is-referenced-by-count":2,"title":["Parenteral Berberine vs Cisplatin- Loaded Lipid Nanoparticles \u2013 Development, Characterisation, Comparative Safety Profiling and Cytotoxicity in Cholangiocarcinoma Cell Models"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Martin","family":"Manov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denitsa","family":"Stefanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Tzankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislav","family":"Tzankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5134-1475","authenticated-orcid":true,"given":"Kevin","family":"Delgado-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-0326","authenticated-orcid":true,"given":"Rocio","family":"Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanka","family":"Spassova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kovacheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-461X","authenticated-orcid":true,"given":"Marta","family":"Slavkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-021-00300-2","volume":"7","author":"Brindley","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.jhep.2021.12.010","volume":"76","author":"Izquierdo-Sanchez","year":"2022","journal-title":"J. Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41575-025-01153-w","volume":"23","author":"Banales","year":"2026","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.hbpd.2022.08.015","volume":"21","author":"Yuan","year":"2022","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11864-023-01153-5","volume":"25","author":"Wheless","year":"2024","journal-title":"Curr Treat Options in Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2217\/imt-2022-0288","volume":"15","author":"Beri","year":"2023","journal-title":"Immunotherapy"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1039\/C8DT00838H","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/onc.2011.384","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"101581","DOI":"10.1016\/j.mtbio.2025.101581","volume":"31","author":"Tang","year":"2025","journal-title":"Materials Today Bio"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12951-022-01626-z","volume":"20","author":"Yadav","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s13659-020-00293-7","volume":"11","author":"Huang","year":"2021","journal-title":"Nat Prod Bioprospect"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.31557\/APJCP.2022.23.10.3379","volume":"23","author":"Obchoei","year":"2022","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"26808","DOI":"10.1038\/s41598-025-11480-2","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.advms.2022.09.003","volume":"67","author":"Skonieczna","year":"2022","journal-title":"Adv. Med. Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/jpp\/rgac067","volume":"75","author":"ying","year":"2023","journal-title":"J Pharm Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1007\/s11094-024-03262-3","volume":"58","author":"Palaniyandi","year":"2024","journal-title":"Pharm Chem J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1080\/14786419.2024.2373960","volume":"39","author":"Rai","year":"2025","journal-title":"Nat Prod Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/pharmaceutics17030331","volume":"17","author":"Stefanova","year":"2025","journal-title":"Pharmaceutics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"575608","DOI":"10.2147\/DDDT.S575608","volume":"20","author":"Qi","year":"2026","journal-title":"Drug Des Devel Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/02652048.2024.2395976","volume":"41","author":"Attia","year":"2024","journal-title":"J. Microencapsul"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"117622","DOI":"10.1016\/j.taap.2025.117622","volume":"506","author":"Farag","year":"2026","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"151555","DOI":"10.1016\/j.bbrc.2025.151555","volume":"754","author":"Zaied","year":"2025","journal-title":"Biochem Biophys Res Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1039\/D5NA00706B","volume":"8","author":"Suman","year":"2026","journal-title":"Nanoscale Adv"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"096","DOI":"10.7324\/JAPS.2025.237203","volume":"15","author":"Sakthivel","year":"2025","journal-title":"J App Pharm Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3892\/or.2016.4785","volume":"36","author":"Zhao","year":"2016","journal-title":"Oncol. Rep"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/cells13030287","volume":"13","author":"Khaled","year":"2024","journal-title":"Cells"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"125134","DOI":"10.1016\/j.ijpharm.2024.125134","volume":"670","author":"Shi","year":"2025","journal-title":"International Journal of Pharmaceutics"},{"key":"ref28","doi-asserted-by":"publisher","author":"Sun","journal-title":"J Adv Res","DOI":"10.1016\/j.jare.2025.10.025"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1080\/22311866.2025.2518163","volume":"15","author":"Laishram","year":"2025","journal-title":"J. Biol. Active Prod. Nature"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2200160","DOI":"10.1002\/adtp.202200160","volume":"6","author":"Xu","year":"2023","journal-title":"Adv Ther"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.5530\/pj.2024.16.165","volume":"16","author":"Bhattacharjee","year":"2024","journal-title":"Pharmacogn.\u00a0Mag"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"136359","DOI":"10.1016\/j.molstruc.2023.136359","volume":"1294","author":"Lu","year":"2023","journal-title":"J. Mol. Struct"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/ptr.5693","volume":"30","author":"Imenshahidi","year":"2016","journal-title":"Phytother. Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jddst.2019.02.017","volume":"51","author":"Salvi","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol"},{"key":"ref35","doi-asserted-by":"publisher","author":"Mall","journal-title":"Intelligent Pharm","DOI":"10.1016\/j.ipha.2024.09.005"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.biopha.2018.04.055","volume":"103","author":"Khosa","year":"2018","journal-title":"Biomed. Pharmacother"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/pharmaceutics12030288","volume":"12","author":"Haider","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"114417","DOI":"10.1016\/j.addr.2022.114417","volume":"188","author":"Nakamura","year":"2022","journal-title":"Adv. Drug Deliv. Rev"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.colsurfb.2010.06.008","volume":"80","author":"Jia","year":"2010","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e202500583","DOI":"10.1002\/sstr.202500583","volume":"7","author":"Kambanis","year":"2026","journal-title":"Small Structures"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1038\/s41598-025-87445-2","volume":"15","author":"Esnaashari","year":"2025","journal-title":"Sci Rep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"147629","DOI":"10.1016\/j.ijbiomac.2025.147629","volume":"328","author":"Xia","year":"2025","journal-title":"Int. J. Biol. Macromol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"6119","DOI":"10.1039\/D5RA08567E","volume":"16","author":"Sharaf","year":"2026","journal-title":"RSC Adv"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1080\/09205063.2022.2155782","volume":"34","author":"Yadav","year":"2023","journal-title":"Biomater.\u00a0Sci. Polym. Ed"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1093\/jpp\/rgaf058","volume":"77","author":"Cao","year":"2025","journal-title":"J Pharm Pharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"100092","DOI":"10.1016\/j.nwnano.2025.100092","volume":"9","author":"Al rashid","year":"2025","journal-title":"Nano Trends"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/07357907.2023.2241083","volume":"41","author":"El-Fakharany","year":"2023","journal-title":"Cancer Investigation"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"10749","DOI":"10.3389\/ebm.2025.10749","volume":"250","author":"Liu","year":"2025","journal-title":"Exp Biol Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3103\/S0095452725030077","volume":"59","author":"Skorokhyd","year":"2025","journal-title":"Cytol Genet"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1080\/14656566.2019.1667335","volume":"20","author":"Filippi","year":"2019","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12247-024-09809-x","volume":"19","author":"Yari","year":"2024","journal-title":"J Pharm Innov"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"124495","DOI":"10.1016\/j.ijpharm.2024.124495","volume":"662","author":"Jia","year":"2024","journal-title":"Int. J. Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"936254","DOI":"10.1155\/2013\/936254","volume":"2013","author":"Basotra","year":"2013","journal-title":"Int Sch Res Notices"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.biopha.2018.10.158","volume":"109","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1080\/03639045.2021.1892745","volume":"47","author":"Saghafi","year":"2021","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"589429","DOI":"10.2147\/NSA.S589429","volume":"19","author":"Nurohman","year":"2026","journal-title":"Nanotechnol. Sci. Appl"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"204925","DOI":"10.1155\/2014\/204925","volume":"2014","author":"Zuo","year":"2014","journal-title":"Biomed Res. Int"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot095505","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"50166","DOI":"10.3791\/50166","author":"Evans","year":"2013","journal-title":"J Vis Exp"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"119990","DOI":"10.1016\/j.lfs.2021.119990","volume":"285","author":"Raju","year":"2021","journal-title":"Life Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/02652048.2022.2131919","volume":"39","author":"Mittal","year":"2022","journal-title":"J. Microencapsul"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.xphs.2021.04.012","volume":"110","author":"Apostolou","year":"2021","journal-title":"J. Pharm. Sci"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.bbamem.2008.12.003","volume":"1788","author":"Fidorra","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/10611860310001615956","volume":"11","author":"G\u00f6ppert","year":"2003","journal-title":"J Drug Target"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.saa.2017.01.008","volume":"176","author":"Georgieva","year":"2017","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"13268","DOI":"10.1039\/C7NJ02423A","volume":"41","author":"Zhang","year":"2017","journal-title":"New J Chem"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1039\/C8CE00114F","volume":"20","author":"Singh","year":"2018","journal-title":"CrystEngComm"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"103156","DOI":"10.1016\/j.cis.2024.103156","volume":"327","author":"Caselli","year":"2024","journal-title":"Adv. Colloid Interface Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"36349","DOI":"10.1038\/s41598-025-20144-0","volume":"15","author":"Demirbolat","year":"2025","journal-title":"Sci Rep"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"926","DOI":"10.3390\/pharmaceutics16070926","volume":"16","author":"Chaudhuri","year":"2024","journal-title":"Pharmaceutics"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fphar.2022.891829","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1002\/hep.32344","volume":"76","author":"de Gauna M","year":"2022","journal-title":"Hepatology"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fcell.2021.629182","author":"Giulitti","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1021\/acs.molpharmaceut.4c00392","volume":"21","author":"Jeitler","year":"2024","journal-title":"Mol Pharmaceutics"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"112122","DOI":"10.1016\/j.biopha.2021.112122","volume":"145","author":"Gendy","year":"2022","journal-title":"Biomed. Pharmacother"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1208\/s12249-014-0106-y","volume":"15","author":"Vhora","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fgstr.2024.1387343","author":"Abolhasanzadeh","year":"2024","journal-title":"Front Gastroenterol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"46830","DOI":"10.1007\/s11356-022-19158-2","volume":"29","author":"Paudel","year":"2022","journal-title":"Environ Sci Pollut Res Int"}],"container-title":["Nanotechnology, Science and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115385","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:15:15Z","timestamp":1779207315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/parenteral-berberine-vs-cisplatin--loaded-lipid-nanoparticles--develop-peer-reviewed-fulltext-article-NSA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":78,"URL":"https:\/\/doi.org\/10.2147\/nsa.s596038","relation":{},"ISSN":["1177-8903"],"issn-type":[{"value":"1177-8903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}