{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:20:19Z","timestamp":1785514819139,"version":"3.56.0"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OPTH"],"DOI":"10.2147\/opth.s256480","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T01:55:02Z","timestamp":1601517302000},"page":"2951-2963","source":"Crossref","is-referenced-by-count":29,"title":["&lt;p&gt;Safety and Efficacy of a Preservative-Free Artificial Tear Containing Carboxymethylcellulose and Hyaluronic Acid for Dry Eye Disease: A Randomized, Controlled, Multicenter 3-Month Study&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-9799","authenticated-orcid":true,"given":"Pasquale","family":"Aragona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M","family":"Ben\u00edtez-del-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3061-2011","authenticated-orcid":true,"given":"Minas T","family":"Coroneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhanjan","family":"Mukherji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-4945","authenticated-orcid":true,"given":"Jacqueline","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Vandewalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-4604","authenticated-orcid":true,"given":"Algis","family":"Vingrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Carlisle-Wilcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Vehige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1167\/iovs.03-0915","volume":"46","author":"Mertzanis","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ajo.2006.11.060","volume":"143","author":"Miljanovi\u0107","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/01.ico.0000214802.40313.fa","volume":"25","author":"Behrens","year":"2006","journal-title":"Cornea"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul Surf"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1444-0938.2011.00634.x","volume":"95","author":"Stahl","year":"2012","journal-title":"Clin Exp Optom"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.exer.2013.08.013","volume":"117","author":"Pflugfelder","year":"2013","journal-title":"Exp Eye Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5503","DOI":"10.1167\/iovs.14-16247","volume":"56","author":"Hua","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","first-page":"1945","volume":"19","author":"Khandekar","year":"2013","journal-title":"Mol Vis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3109\/02713683.2014.957776","volume":"40","author":"Hua","year":"2015","journal-title":"Curr Eye Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"058","DOI":"10.23937\/2378-346X\/1410058","volume":"3","author":"Giannaccare","year":"2016","journal-title":"Int J Ophthalmol Clin Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1515\/bmc-2012-0001","volume":"3","author":"Brocker","year":"2012","journal-title":"Biomol Concepts"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/pharmaceutics10030137","volume":"10","author":"Tampucci","year":"2018","journal-title":"Pharmaceutics"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2147\/opth.S157853","volume":"12","author":"Mateo Orobia","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2147\/OPTH.S78184","volume":"9","author":"Simmons","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1167\/iovs.06-0848","volume":"48","author":"Garrett","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1006\/exer.1998.0567","volume":"67","author":"Lerner","year":"1998","journal-title":"Exp Eye Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.2147\/OPTH.S135550","volume":"11","author":"Simmons","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1167\/iovs.13-12081","volume":"54","author":"Chen","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/ICO.0b013e318165b19e","volume":"27","author":"Corrales","year":"2008","journal-title":"Cornea"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/archopht.118.5.615","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1365-2133.2005.06389.x","volume":"152","author":"Aragona","year":"2005","journal-title":"Br J Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/10543409508835115","volume":"5","author":"Morikawa","year":"1995","journal-title":"J Biopharm Stat"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00003226-199801000-00007","volume":"17","author":"Pflugfelder","year":"1998","journal-title":"Cornea"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/ICO.0b013e31816f630e","volume":"27","author":"Rolando","year":"2008","journal-title":"Cornea"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1001\/archopht.1969.00990020012003","volume":"82","author":"van Bijsterveld","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0161-6420(97)30330-3","volume":"104","author":"Pflugfelder","year":"1997","journal-title":"Ophthalmology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/978-1-4615-0717-8_157","volume":"506","author":"Abelson","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/ICO.0b013e3181e9adcc","volume":"30","author":"Lee","year":"2011","journal-title":"Cornea"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"751","DOI":"10.5301\/ejo.5000117","volume":"22","author":"Baudouin","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1136\/bjo.86.8.879","volume":"86","author":"Aragona","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/bjo.86.2.181","volume":"86","author":"Aragona","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/eye.2017.73","volume":"31","author":"Labetoulle","year":"2017","journal-title":"Eye"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/OPX.0000000000000878","volume":"93","author":"Nichols","year":"2016","journal-title":"Optom Vis Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.jcrs.2014.12.056","volume":"41","author":"Mencucci","year":"2015","journal-title":"J Cataract Refract Surg"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"839","DOI":"10.2147\/OPTH.S163744","volume":"12","author":"Wallerstein","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/0014-4835(91)90110-Z","volume":"53","author":"Nishida","year":"1991","journal-title":"Exp Eye Res"},{"key":"ref42","first-page":"2313","volume":"34","author":"Inoue","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/tvst.8.6.2","volume":"8","author":"Aragona","year":"2019","journal-title":"Transl Vis Sci Tech"},{"key":"ref44","author":"Rivas","journal-title":"Controversies in Ophthalmology (COPHy) - 8th World Congress; March 30, 2017; Madrid, Spain"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1021\/acsbiomaterials.5b00181","volume":"1","author":"Rayahin","year":"2015","journal-title":"ACS Biomater Sci Eng"},{"key":"ref46","first-page":"4899","volume":"59","author":"Simmons","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Clinical Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=62018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=62018","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T01:55:05Z","timestamp":1601517305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/safety-and-efficacy-of-a-preservative-free-artificial-tear-containing--peer-reviewed-article-OPTH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/opth.s256480","relation":{},"ISSN":["1177-5483"],"issn-type":[{"value":"1177-5483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}