{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:20:50Z","timestamp":1778894450760,"version":"3.51.4"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OPTH"],"DOI":"10.2147\/opth.s309703","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T22:47:17Z","timestamp":1620946037000},"page":"2025-2036","source":"Crossref","is-referenced-by-count":5,"title":["OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Marta","family":"Para-Prieto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-619X","authenticated-orcid":true,"given":"Raul","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2066-3621","authenticated-orcid":true,"given":"Sara","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mena-Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Valisena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandro","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gonzalez Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Arenillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Tellez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-7306","authenticated-orcid":true,"given":"Jose Carlos","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/eye.2015.158","volume":"29","author":"Jones-Odeh","year":"2015","journal-title":"Eye (Lond)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S1474-4422(17)30278-8","volume":"16","author":"Petzold","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref3","first-page":"2520","volume":"40","author":"Parisi","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"530305","DOI":"10.1155\/2012\/530305","volume":"2012","author":"Oberwahrenbrock","year":"2012","journal-title":"Mult Scler Int"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1001\/jamaneurol.2013.573","volume":"70","author":"Saidha","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/ana.24487","volume":"78","author":"Saidha","year":"2015","journal-title":"Ann Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1177\/1352458513518626","volume":"20","author":"Balk","year":"2014","journal-title":"Mult Scler J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11940-017-0452-7","volume":"19","author":"Brandt","year":"2017","journal-title":"Curr Treat Options Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11940-018-0493-6","volume":"20","author":"Lambe","year":"2018","journal-title":"Curr Treat Options Neurol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.msard.2018.02.010","volume":"21","author":"Behbehani","year":"2018","journal-title":"Mult Scler Relat Disord"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e01467","DOI":"10.1002\/brb3.1467","volume":"9","author":"Carcel\u00e9n\u2010Gadea","year":"2019","journal-title":"Brain Behav"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3389\/fneur.2017.00701","volume":"8","author":"Doustar","year":"2017","journal-title":"Front Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.preteyeres.2006.10.002","volume":"26","author":"van Velthoven","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1167\/iovs.16-20969","volume":"58","author":"Miller","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.12688\/f1000research.19979.1","volume":"8","author":"Davila","year":"2019","journal-title":"F1000Research"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/WNO.0b013e3181facbbd","volume":"31","author":"Watson","year":"2011","journal-title":"J Neuroophthalmol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6536","DOI":"10.1167\/iovs.14-15072","volume":"55","author":"Matlach","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ajo.2010.06.041","volume":"151","author":"Leite","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"ref19","first-page":"1","volume":"27","author":"Oertel","year":"2018","journal-title":"Expert Rev Neurother"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1212\/WNL.0000000000002774","volume":"86","author":"Cruz-Herranz","year":"2016","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1352458514538110","volume":"21","author":"Schippling","year":"2015","journal-title":"Mult Scler J"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/WCO.0b013e328334e99b","volume":"23","author":"Jindahra","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2147\/EB.S139417","volume":"10","author":"Costello","year":"2018","journal-title":"Eye Brain"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8503859","DOI":"10.1155\/2016\/8503859","volume":"2016","author":"Satue","year":"2016","journal-title":"J Ophthalmol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.8.5.6","volume":"8","author":"Wong","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1016\/j.ophtha.2012.05.003","volume":"119","author":"Garcia-Martin","year":"2012","journal-title":"Ophthalmology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ophtha.2018.08.009","volume":"126","author":"Chan","year":"2019","journal-title":"Ophthalmology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"16345","DOI":"10.1038\/s41598-018-34577-3","volume":"8","author":"S\u00e1nchez","year":"2018","journal-title":"Sci Rep"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1038\/s41598-020-58399-4","volume":"10","author":"S\u00e1nchez","year":"2020","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sjopt.2014.09.016","volume":"29","author":"Rebolleda","year":"2015","journal-title":"Saudi J Ophthalmol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1177\/1352458517729463","volume":"24","author":"Lanzillo","year":"2018","journal-title":"Mult Scler J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3389\/fneur.2020.00542","volume":"11","author":"Cennamo","year":"2020","journal-title":"Front Neurol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/ceo.13067","volume":"46","author":"Huo","year":"2018","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.ophtha.2018.03.026","volume":"125","author":"Mauschitz","year":"2018","journal-title":"Ophthalmology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3129\/i10-063","volume":"45","author":"Costello","year":"2010","journal-title":"Can J Ophthalmol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/ana.20851","volume":"59","author":"Costello","year":"2006","journal-title":"Ann Neurol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1177\/1352458517694090","volume":"24","author":"Coric","year":"2018","journal-title":"Mult Scler J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1111\/ene.13443","volume":"24","author":"Coric","year":"2017","journal-title":"Eur J Neurol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"128517","DOI":"10.1155\/2014\/128517","volume":"2014","author":"Gonz\u00e1lez-L\u00f3pez","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1177\/1352458512439237","volume":"18","author":"Albrecht","year":"2012","journal-title":"Mult Scler J"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/brain\/awr264","volume":"135","author":"Syc","year":"2012","journal-title":"Brain"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e0221466","DOI":"10.1371\/journal.pone.0221466","volume":"14","author":"Dom\u00ednguez-Vicent","year":"2019","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00417-011-1811-9","volume":"250","author":"T\u00f6teberg-Harms","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1167\/iovs.07-0834","volume":"48","author":"Gundogan","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.3390\/jcm9113766","volume":"9","author":"Ziccardi","year":"2020","journal-title":"J Clin Med"}],"container-title":["Clinical Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=69419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=69419","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T22:47:19Z","timestamp":1620946039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/oct-variability-prevents-their-use-as-robust-biomarkers-in-multiple-sc-peer-reviewed-fulltext-article-OPTH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/opth.s309703","relation":{},"ISSN":["1177-5483"],"issn-type":[{"value":"1177-5483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}