{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:58:40Z","timestamp":1782982720923,"version":"3.54.5"},"reference-count":69,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OPTH"],"DOI":"10.2147\/opth.s362691","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:10:20Z","timestamp":1664496620000},"page":"3225-3246","source":"Crossref","is-referenced-by-count":17,"title":["Late-Onset Retinal Degeneration: Clinical Perspectives"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Leonardo","family":"Lando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamanga","family":"Borooah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1097\/IAE.0000000000003017","volume":"41","author":"Borooah","year":"2021","journal-title":"Retina"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/13816810.2021.1923041","volume":"42","author":"De Zaeytijd","year":"2021","journal-title":"Ophthalmic Genet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1136\/bjo.2008.150151","volume":"93","author":"Borooah","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1097\/IAE.0000000000001113","volume":"36","author":"Cukras","year":"2016","journal-title":"Retina"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1001\/jamaophthalmol.2014.2059","volume":"132","author":"Jacobson","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1097\/IAE.0000000000003205","volume":"41","author":"Keenan","year":"2021","journal-title":"Retina"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/tvst.9.6.26","volume":"9","author":"Khan","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.jcrs.2017.05.041","volume":"43","author":"Papastavrou","year":"2017","journal-title":"J Cataract Refract Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1097\/IAE.0000000000003082","volume":"41","author":"Vanderford","year":"2021","journal-title":"Retina"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.oret.2020.12.012","volume":"5","author":"Borooah","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1097\/IAE.0b013e318240a574","volume":"32","author":"Vincent","year":"2012","journal-title":"Retina"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001067","author":"Papastavrou","year":"2020","journal-title":"Retin Cases Brief Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/BF02143075","volume":"224","author":"Duvall","year":"1986","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref14","first-page":"1772","volume":"37","author":"Kuntz","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1001\/archopht.118.1.85","volume":"118","author":"Ayyagari","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1016\/S0161-6420(00)00419-X","volume":"107","author":"Milam","year":"2000","journal-title":"Ophthalmology"},{"key":"ref17","first-page":"1882","volume":"42","author":"Jacobson","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1093\/hmg\/ddg289","volume":"12","author":"Hayward","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/sj.eye.6700408","volume":"17","author":"Styles","year":"2003","journal-title":"Eye"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1167\/iovs.05-0159","volume":"46","author":"Ayyagari","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.ajo.2005.06.023","volume":"140","author":"Subrayan","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/eye.2010.71","volume":"24","author":"Aye","year":"2010","journal-title":"Eye"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1111\/aos.12010","volume":"91","author":"Soumplis","year":"2013","journal-title":"Acta Ophthalmol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jcjo.2014.12.001","volume":"50","author":"Papastavrou","year":"2015","journal-title":"Can J Ophthalmol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41433-019-0348-8","volume":"33","author":"Mandal","year":"2019","journal-title":"Eye"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.oret.2018.11.010","volume":"3","author":"Ramtohul","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1167\/iovs.15-18593","volume":"57","author":"Fleckenstein","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"12147","DOI":"10.1038\/s41598-017-11898-3","volume":"7","author":"Stanton","year":"2017","journal-title":"Sci Rep"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1080\/13816810.2018.1546406","volume":"39","author":"Borooah","year":"2018","journal-title":"Ophthalmic Genet"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2017.03.003","volume":"59","author":"Broadgate","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/ceo.13917","volume":"49","author":"Georgiou","year":"2021","journal-title":"Clin Exp Ophthalmol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1167\/iovs.05-0159","volume":"46","author":"Ayyagari","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/j.1442-9071.2012.02787.x","volume":"40","author":"Roberts","year":"2012","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archophthalmol.2007.53","volume":"126","author":"Bressler","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1167\/iovs.07-1584","volume":"49","author":"Chang","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0960-9822(98)70133-2","volume":"8","author":"Shapiro","year":"1998","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/hmg\/ddl091","volume":"15","author":"Shu","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.jsb.2012.07.011","volume":"180","author":"Tu","year":"2012","journal-title":"J Struct Biol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1042\/BJ20081240","volume":"416","author":"Wong","year":"2008","journal-title":"Biochem J"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jsb.2014.02.001","volume":"186","author":"Tu","year":"2014","journal-title":"J Struct Biol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1038\/s42003-021-02872-x","volume":"4","author":"Miyagishima","year":"2021","journal-title":"Commun Biol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e13011","DOI":"10.1111\/acel.13011","volume":"18","author":"Chekuri","year":"2019","journal-title":"Aging Cell"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1093\/hmg\/ddr080","volume":"20","author":"Chavali","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref45","unstructured":"ClinVar VCV000813996.1. National Center for Biotechnology Information; 2018. Available from: https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/variation\/VCV000813996.1. Accessed July 25, 2022."},{"key":"ref46","first-page":"4532","volume":"63","author":"Alex","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref47","first-page":"4408","volume":"63","author":"Lando","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1167\/iovs.06-0312","volume":"47","author":"Mandal","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/S0002-9394(03)00657-3","volume":"136","author":"Moroi","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1167\/iovs.17-23705","volume":"59","author":"Roberts","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/ceo.12554","volume":"43","author":"Roberts","year":"2015","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/00006324-200211000-00005","volume":"79","author":"Roberts","year":"2002","journal-title":"Optom Vis Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/tvst.11.1.19","volume":"11","author":"Shmueli","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.2147\/OPTH.S145932","volume":"11","author":"Caramoy","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/13816810590968032","volume":"26","author":"Ben-Arie-Weintrob","year":"2005","journal-title":"Ophthalmic Genet"},{"key":"ref57","unstructured":"C1q and TNF related 5. National Center for Biotechnology Information; 2018. Available from: https:\/\/www.ncbi.nlm.nih.gov\/gene\/114902#gene-expression. Accessed July 25, 2022."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10633-019-09705-7","volume":"139","author":"Tsunoda","year":"2019","journal-title":"Doc Ophthalmol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/9707","volume":"22","author":"Yamamoto","year":"1999","journal-title":"Nat Genet"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/sj.eye.6702212","volume":"21","author":"McBain","year":"2007","journal-title":"Eye"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00439-016-1637-y","volume":"135","author":"Ghazi","year":"2016","journal-title":"Hum Genet"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1056\/NEJMoa0802268","volume":"358","author":"Bainbridge","year":"2008","journal-title":"N Engl J Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41591-018-0295-0","volume":"25","author":"Cideciyan","year":"2019","journal-title":"Nat Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/s41591-022-01755-w","volume":"28","author":"Russell","year":"2022","journal-title":"Nat Med"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/mt.2009.277","volume":"18","author":"Simonelli","year":"2010","journal-title":"Mol Ther"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/scitranslmed.aaz7423","volume":"12","author":"Yu-Wai-Man","year":"2020","journal-title":"Sci Transl Med"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1080\/15476286.2018.1504546","volume":"16","author":"Gleditzsch","year":"2019","journal-title":"RNA Biol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1186\/s13023-021-02145-0","volume":"16","author":"Lam","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1016\/j.ophtha.2012.05.047","volume":"119","author":"Stone","year":"2012","journal-title":"Ophthalmology"}],"container-title":["Clinical Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84382","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:10:30Z","timestamp":1664496630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/late-onset-retinal-degeneration-clinical-perspectives-peer-reviewed-fulltext-article-OPTH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":69,"URL":"https:\/\/doi.org\/10.2147\/opth.s362691","relation":{},"ISSN":["1177-5483"],"issn-type":[{"value":"1177-5483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}