{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:40:04Z","timestamp":1787024404077,"version":"build-2736575974"},"reference-count":50,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OPTH"],"DOI":"10.2147\/opth.s428725","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:15:21Z","timestamp":1702426521000},"page":"3883-3898","source":"Crossref","is-referenced-by-count":27,"title":["Safe and Effective Management of Dry Eye Symptoms with Hydroxypropyl Guar and Hyaluronic Acid Dual-Polymer Lubricating Eye Drops: A Review of Preclinical and Clinical Studies"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Sruthi","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravaughn","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8642","DOI":"10.26355\/eurrev_202009_22801","volume":"24","author":"Barabino","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s1542-0124(12)70081-2","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul Surf"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1586\/eop.10.89","volume":"6","author":"M\u00f3dis","year":"2011","journal-title":"Expert Rev Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009729.pub2","volume":"2016","author":"Pucker","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052434","volume":"23","author":"Labetoulle","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics13020207","volume":"13","author":"Agarwal","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1136\/bjophthalmol-2016-308608","volume":"101","author":"Labetoulle","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.2147\/OPTH.S177176","volume":"12","author":"Labetoulle","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1097\/ICO.0b013e3181ca636b","volume":"29","author":"Moon","year":"2010","journal-title":"Cornea"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1089\/jop.2018.0151","volume":"35","author":"Posarelli","year":"2019","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/ICO.0000000000000358","volume":"34","author":"Schmidl","year":"2015","journal-title":"Cornea"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1089\/jop.2016.0086","volume":"33","author":"Park","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref19","unstructured":"Systane Hydration drug facts. Available from: https:\/\/fda.report\/DailyMed\/8936f66f-10fe-44ab-a26e-dd8b05dfa997. Accessed January 11, 2023."},{"key":"ref20","unstructured":"Jones L, Ngo W, Yeh T SYSTANE \u00ae HYDRATION PF\u2019s Dual-Polymer Technology: hydroxypropyl-Guar and Sodium Hyaluronate [White Paper]. Available from: Https:\/\/Us.Alconscience.Com\/Sites\/g\/Files\/Rbvwei1736\/Files\/Pdf\/SYSTANE-HYDRATION-PFs-Dua. Accessed January 11, 2023."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/tvst.8.6.2","volume":"8","author":"Aragona","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1089\/jop.2014.0164","volume":"31","author":"Rangarajan","year":"2015","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/OPX.0000000000001082","volume":"94","author":"Bitton","year":"2017","journal-title":"Optom Vis Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12325-010-0052-3","volume":"27","author":"Springs","year":"2010","journal-title":"Adv Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2147\/OPTH.S13773","volume":"5","author":"Benelli","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1080\/08164622.2021.1925208","volume":"104","author":"Garofalo","year":"2021","journal-title":"Clin Exp Optom"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"695","DOI":"10.2147\/OPTH.S150587","volume":"12","author":"Ng","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.2147\/OPTH.S261318","volume":"14","author":"Yeu","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/jop.2010.0025","volume":"26","author":"Davitt","year":"2010","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.2147\/OPTH.S81355","volume":"9","author":"Fernandez","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/polym10070701","volume":"10","author":"Fallacara","year":"2018","journal-title":"Polymers (Basel)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12167","volume":"92","author":"L\u00f5pez-Garc\u00eda","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/aos.15159","volume":"100","author":"Hynnekleiv","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.optm.2010.08.003","volume":"82","author":"Rah","year":"2011","journal-title":"Optometry"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1089\/jop.2018.0069","volume":"34","author":"Szegedi","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/15569527.2019.1673402","volume":"39","author":"Seino","year":"2020","journal-title":"Cutan Ocul Toxicol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.2147\/OPTH.S211611","volume":"13","author":"Walsh","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/ICO.0000000000000695","volume":"35","author":"Kim","year":"2015","journal-title":"Cornea"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41433-021-01668-x","volume":"36","author":"Goldstein","year":"2022","journal-title":"Eye"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jtos.2017.05.004","volume":"15","author":"Gomes","year":"2017","journal-title":"Ocul Surf"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1007\/s11095-017-2270-8","volume":"34","author":"Hsu","year":"2017","journal-title":"Pharm Res"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.4172\/clinical-investigation.1000126","volume":"07","author":"Kaarniranta","year":"2018","journal-title":"Clin Investig"},{"key":"ref43","first-page":"16","volume":"2020","author":"Davidson","year":"2020","journal-title":"ONdrugDelivery"},{"key":"ref44","first-page":"4460","volume":"58","author":"SAIDANE","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1089\/jop.2017.0080","volume":"34","author":"Carlson","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.2147\/OPTH.S259704","volume":"14","author":"Favuzza","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.31436\/imjm.v18i2.613","volume":"18","author":"Che Arif","year":"2020","journal-title":"IIUM Med J Malaysia"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/ICL.0000000000000855","volume":"48","author":"Tan","year":"2022","journal-title":"Eye Contact Lens"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.2147\/OPTH.S391082","volume":"16","author":"Pastor-Pascual","year":"2022","journal-title":"Clin Ophthalmol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2147\/opto.s398496","volume":"15","author":"Pucker","year":"2023","journal-title":"Clin Optom"}],"container-title":["Clinical Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95246","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:15:26Z","timestamp":1702426526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/safe-and-effective-management-of-dry-eye-symptoms-with-hydroxypropyl-g-peer-reviewed-fulltext-article-OPTH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":50,"URL":"https:\/\/doi.org\/10.2147\/opth.s428725","relation":{},"ISSN":["1177-5483"],"issn-type":[{"value":"1177-5483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}