{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:22:12Z","timestamp":1780100532117,"version":"3.54.0"},"reference-count":56,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OPTH"],"DOI":"10.2147\/opth.s540312","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:45:12Z","timestamp":1755791112000},"page":"2913-2925","source":"Crossref","is-referenced-by-count":3,"title":["Maximum Tolerated Medical Therapy for Glaucoma: Fixed-Dose Combinations of Timolol, Dorzolamide, Brimonidine with Latanoprost Versus Timolol, Dorzolamide with Latanoprost"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-349X","authenticated-orcid":true,"given":"Oscar","family":"Olvera-Monta\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mejia-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Jauregui-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-0961","authenticated-orcid":true,"given":"Sandra","family":"Gomez-Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-1218","authenticated-orcid":true,"given":"Patricia","family":"Mu\u00f1oz-Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref2","author":"Barr\u00eda von-Bischhoffshausen","year":"2019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9570.1000575","volume":"07","author":"Garc\u00eda Luna","year":"2016","journal-title":"J Clin Exp Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1016\/j.ophtha.2011.01.047","volume":"118","author":"Musch","year":"2011","journal-title":"Ophthalmology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1001\/archopht.120.6.701","volume":"120","author":"Kass","year":"2002","journal-title":"Archives of Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1001\/archopht.126.8.1030","volume":"126","author":"Chauhan","year":"2008","journal-title":"Archives of Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1001\/archopht.121.1.48","volume":"121","author":"Leske","year":"2003","journal-title":"Archives of Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2147\/OPTH.S64584","author":"Markus","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","author":"Aung","journal-title":"Clin Ophthalmol","DOI":"10.2147\/OPTH.S72380"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10792-013-9823-6","volume":"34","author":"Lazcano-Gomez","year":"2014","journal-title":"Int Ophthalmol"},{"key":"ref11","first-page":"1","volume":"4","author":"Higginbotham","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1517\/14656566.2014.936850","volume":"15","author":"Holl\u00f3","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"626","DOI":"10.2298\/SARH1510626B","volume":"143","author":"Babic","year":"2015","journal-title":"Srp Arh Celok Lek"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1001\/archopht.1997.01100160749014","volume":"115","author":"Zimmerman","year":"1997","journal-title":"Archives of Ophthalmol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.2147\/OPTH.S228777","volume":"13","author":"Lerner","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"ref16","doi-asserted-by":"publisher","volume-title":"The Glaucomas","year":"2014","DOI":"10.1007\/978-3-642-35500-4"},{"key":"ref17","doi-asserted-by":"publisher","author":"Baiza-Dur\u00e1n","journal-title":"Clin Ophthalmol","DOI":"10.2147\/OPTH.S33578"},{"key":"ref18","first-page":"174","volume":"41","author":"Baiza-Dur\u00e1n","year":"2009","journal-title":"Ann Ophthalmol"},{"key":"ref19","unstructured":"Olvera-Monta\u00f1o O. Safety and tolerability of the preservative-free ophthalmic solution PRO-122 compared with krytantek ofteno\u00ae (PRO-122\/I) (ClinicalTrials.gov: NCT03966365). Available from: https:\/\/clinicaltrials.gov\/study\/NCT03966365?term=NCT03966365&rank=1. Accessed August 18, 2025."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/17469899.2019.1570138","volume":"14","author":"Costa","year":"2019","journal-title":"Expert Rev Ophthalmol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"P71","DOI":"10.1016\/j.ophtha.2020.10.022","volume":"128","author":"Gedde","year":"2021","journal-title":"Ophthalmology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1167\/iovs.06-1253","volume":"48","author":"Johnson","year":"2007","journal-title":"Investigat Opthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3390\/diagnostics10080559","volume":"10","author":"Okumura","year":"2020","journal-title":"Diagnostics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jtos.2017.01.005","volume":"15","author":"McAlinden","year":"2017","journal-title":"Ocul Surf"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1167\/iovs.14-14276","volume":"55","author":"Chao","year":"2014","journal-title":"Investigat Opthalmol Vis Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"15142","DOI":"10.3390\/ijerph192215142","volume":"19","author":"Barrio","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.2174\/1381612825666190416115714","volume":"25","author":"Dang","year":"2019","journal-title":"Curr Pharm Des"},{"key":"ref28","unstructured":"WHO-UMC. The Use of the WHO-UMC system for standardised case causality assessment. Available from: https:\/\/www.who.int\/publications\/m\/item\/WHO-causality-assessment. Accessed August 18, 2025."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1080\/10543400903242795","volume":"19","author":"DeSouza","year":"2009","journal-title":"J Biopharm Stat"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1136\/ebmh.4.3.70","volume":"4","author":"Streiner","year":"2001","journal-title":"Evid Based Ment Health"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s10384-019-00673-8","volume":"63","author":"Joh","year":"2019","journal-title":"Jpn J Ophthalmol"},{"key":"ref32","doi-asserted-by":"publisher","volume-title":"Sample Size Calculations in Clinical Research","year":"2007","DOI":"10.1201\/9781584889830"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.tjo.2012.08.001","volume":"2","author":"Wang","year":"2012","journal-title":"Taiwan J Ophthalmol"},{"key":"ref34","doi-asserted-by":"publisher","author":"Radcliffe","journal-title":"Clin Ophthalmol","DOI":"10.2147\/OPTH.S76053"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/S0002-9394(02)01418-6","volume":"133","author":"O\u2019Connor","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.2147\/OPTH.S494949","volume":"18","author":"Huang","year":"2024","journal-title":"Clin Ophthalmol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1097\/IJG.0000000000000987","volume":"27","author":"Bro","year":"2018","journal-title":"J Glaucoma"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jcjo.2015.03.009","volume":"50","author":"Juncal","year":"2015","journal-title":"Can J Ophthalmol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF02849799","volume":"20","author":"Mundorf","year":"2003","journal-title":"Adv Ther"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1080\/17512433.2023.2279740","volume":"16","author":"Mu\u00f1oz-Villegas","year":"2023","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1007\/s40123-023-00730-z","volume":"12","author":"Quaranta","year":"2023","journal-title":"Ophthalmol Ther"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/02713683.2022.2041041","volume":"48","author":"Scelfo","year":"2023","journal-title":"Curr Eye Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"374","DOI":"10.4103\/IJO.IJO_618_23","volume":"72","author":"Srivastava","year":"2024","journal-title":"Indian J Ophthalmol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1167\/iovs.15-17455","volume":"57","author":"Villani","year":"2016","journal-title":"Investigat Opthalmol Vis Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2165\/11588830-000000000-00000","volume":"28","author":"Servat","year":"2011","journal-title":"Drugs Aging"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s10384-016-0426-4","volume":"60","author":"Yanagi","year":"2016","journal-title":"Jpn J Ophthalmol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/ICU.0000000000000335","volume":"28","author":"Sng","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/s41433-018-0033-3","volume":"32","author":"Belovay","year":"2018","journal-title":"Eye"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1167\/iovs.02-0641","volume":"44","author":"Hahn","year":"2003","journal-title":"Investigat Opthalmol Vis Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000225963","volume":"42","author":"Cheng","year":"2009","journal-title":"Ophthalmic Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"474","DOI":"10.18240\/ijo.2020.03.16","volume":"13","author":"Yang","year":"2020","journal-title":"Int J Ophthalmol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s40123-018-0128-8","volume":"7","author":"G\u00f3mez-Aguayo","year":"2018","journal-title":"Ophthalmol Ther"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.15761\/NFO.1000202","volume":"4","author":"Sanchez-Castellanos","year":"2018","journal-title":"New Front Ophthalmol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.2147\/OPTH.S369626","volume":"16","author":"Menon","year":"2022","journal-title":"Clin Ophthalmol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/ICU.0b013e3283360b1e","volume":"21","author":"Kim","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ajo.2012.02.014","volume":"154","author":"Varma","year":"2012","journal-title":"Am J Ophthalmol"}],"container-title":["Clinical Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106060","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:45:15Z","timestamp":1755791115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/maximum-tolerated-medical-therapy-for-glaucoma-fixed-dose-combinations-peer-reviewed-fulltext-article-OPTH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":56,"URL":"https:\/\/doi.org\/10.2147\/opth.s540312","relation":{},"ISSN":["1177-5483"],"issn-type":[{"value":"1177-5483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}