{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:08:19Z","timestamp":1747206499015,"version":"3.40.5"},"reference-count":23,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORR"],"DOI":"10.2147\/orr.s400111","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:15:14Z","timestamp":1679480114000},"page":"39-45","source":"Crossref","is-referenced-by-count":0,"title":["Osteoporosis, Fractures, and Blindness Due to a Missense Mutation in the LRP5 Receptor"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-2423","authenticated-orcid":true,"given":"Jake","family":"Littman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanika","family":"Phornphutkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Saade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Katarincic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-2267","authenticated-orcid":true,"given":"Roy","family":"Aaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/s0092-8674(01)00571-2","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e20162398","DOI":"10.1542\/peds.2016-2398","volume":"138","author":"Bachrach","year":"2016","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jbspin.2004.10.008","volume":"72","author":"Levasseur","year":"2005","journal-title":"Joint Bone Spine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1080\/07853890.2022.2146744","volume":"54","author":"Mao","year":"2022","journal-title":"Ann Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00198-015-3245-4","volume":"27","author":"Kheir","year":"2016","journal-title":"Osteoporos Int"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.22608\/APO.201855","volume":"7","author":"Tauqeer","year":"2018","journal-title":"Asia Pac J Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/eye.2014.70","volume":"29","author":"Gilmour","year":"2015","journal-title":"Eye"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.preteyeres.2018.11.008","volume":"70","author":"Wang","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e121031","DOI":"10.5812\/ijem-121031","volume":"20","author":"Homaei","year":"2022","journal-title":"Int J Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s00198-022-06313-1","volume":"33","author":"Abdel-Hamid","year":"2022","journal-title":"Osteoporos Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4161\/org.4.2.5851","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/bonekey.2012.1","volume":"1","author":"Johnson","year":"2012","journal-title":"Bonekey Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1002\/jbmr.462","volume":"26","author":"Goltzman","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1083\/jcb.200201089","volume":"157","author":"Kato","year":"2002","journal-title":"J Cell Biol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nm.2388","volume":"17","author":"Cui","year":"2011","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1038\/nm.3697","volume":"20","author":"Cui","year":"2014","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/ocr.12282","volume":"22","author":"Bullock","year":"2019","journal-title":"Orthod Craniofac Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"985304","DOI":"10.3389\/fendo.2022.985304","volume":"13","author":"Khrystoforova","year":"2022","journal-title":"Front Endocrinol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cell.2008.09.059","volume":"135","author":"Yadav","year":"2008","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e2021","DOI":"10.1002\/mgg3.2021","volume":"10","author":"Qu","year":"2022","journal-title":"Mol Genet Genomic Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1136\/bjophthalmol-2018-312366","volume":"102","author":"Tang","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0271326","DOI":"10.1371\/journal.pone.0271326","volume":"17","author":"Wang","year":"2022","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"5782536","DOI":"10.1155\/2019\/5782536","volume":"2019","author":"Xiao","year":"2019","journal-title":"J Ophthalmol"}],"container-title":["Orthopedic Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88375","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:15:16Z","timestamp":1679480116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/osteoporosis-fractures-and-blindness-due-to-a-missense-mutation-in-the-peer-reviewed-fulltext-article-ORR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":23,"URL":"https:\/\/doi.org\/10.2147\/orr.s400111","relation":{},"ISSN":["1179-1462"],"issn-type":[{"type":"electronic","value":"1179-1462"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}