{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:37:26Z","timestamp":1770226646827,"version":"3.49.0"},"reference-count":81,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORR"],"DOI":"10.2147\/orr.s551680","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:55:12Z","timestamp":1770184512000},"page":"1-19","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Omics Bioinformatic Analyses Linking LOXL4 with Spondylolisthesis"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-8121","authenticated-orcid":true,"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyue","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40945-021-00113-2","volume":"11","author":"Vanti","year":"2021","journal-title":"Arch Physiother"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"36917","DOI":"10.52965\/001c.36917","volume":"14","author":"Li","year":"2022","journal-title":"Orthop Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.3171\/2017.10.FOCUS17652","volume":"44","author":"Heary","year":"2018","journal-title":"Neurosurg Focus"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.spinee.2021.03.005","volume":"21","author":"Reitman","year":"2021","journal-title":"Spine J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2453466","DOI":"10.1001\/jamanetworkopen.2024.53466","volume":"8","author":"Seip","journal-title":"JAMA Network Open"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1055\/s-0031-1298615","volume":"3","author":"Devine","year":"2012","journal-title":"Evid Based Spine Care J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1186\/s13018-024-05346-y","volume":"19","author":"Wang","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e326","DOI":"10.1016\/j.wneu.2024.05.108","volume":"188","author":"Li","year":"2024","journal-title":"World Neurosurg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1172920","DOI":"10.3389\/fphar.2023.1172920","volume":"14","author":"Xu","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"107119","DOI":"10.1016\/j.phrs.2024.107119","volume":"202","author":"Song","year":"2024","journal-title":"Pharmacol Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22203\/ecm.v025a01","volume":"25","author":"Guterl","year":"2013","journal-title":"Eur Cell Mater"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.spinee.2013.01.041","volume":"13","author":"Mayer","year":"2013","journal-title":"Spine J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"E741","DOI":"10.1097\/BRS.0b013e3181f9f575","volume":"36","author":"Moke","year":"2011","journal-title":"Spine"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1302\/0301-620x.86b7.14994","volume":"86","author":"Matsui","year":"2004","journal-title":"J Bone Joint Surg Br"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e015644","DOI":"10.1136\/bmjopen-2016-015644","volume":"7","author":"Jiang","year":"2017","journal-title":"BMJ Open"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"830","DOI":"10.2106\/JBJS.22.00872","volume":"105","author":"Bovonratwet","year":"2023","journal-title":"J Bone Joint Surg Am"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14715\/cmb\/2018.64.10.10","volume":"64","author":"Kitis","year":"2018","journal-title":"Cell Mol Biol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1093\/eurheartj\/ehad736","volume":"44","author":"Larsson","year":"2023","journal-title":"Eur Heart J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/genes14010211","volume":"14","author":"Wang","journal-title":"Genes"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52155","volume":"9","author":"van der Wijst","year":"2020","journal-title":"Elife"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1038\/s41467-018-04558-1","volume":"9","author":"Qi","year":"2018","journal-title":"Nat Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"14748","DOI":"10.1038\/s41598-025-98070-4","volume":"15","author":"Lin","year":"2025","journal-title":"Sci Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1038\/s41592-023-02133-1","volume":"20","author":"Tang","year":"2023","journal-title":"Nat Methods"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41588-022-01154-4","volume":"54","author":"Qi","year":"2022","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"17605","DOI":"10.1038\/s41598-018-35871-w","volume":"8","author":"McRae","year":"2018","journal-title":"Sci Rep"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.3390\/ijms23073993","volume":"23","author":"Cherif","journal-title":"Int J Mol Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e2309032","DOI":"10.1002\/advs.202309032","volume":"11","author":"Swahn","year":"2024","journal-title":"Adv Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"164212","DOI":"10.1016\/j.scitotenv.2023.164212","volume":"892","author":"Liu","year":"2023","journal-title":"Sci Total Environ"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s12672-025-02692-z","volume":"16","author":"Zhang","journal-title":"Discov Oncol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"25626","DOI":"10.1038\/s41598-025-10851-z","volume":"15","author":"Yao","year":"2025","journal-title":"Sci Rep"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1177\/2309499017713917","author":"Takashi","year":"2017","journal-title":"J Orthop Surg"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"0501","DOI":"10.1097\/brs.0b013e3181f9f575","author":"Lieven","year":"2011","journal-title":"Spine"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc3319","volume":"12","author":"Barker","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2023-eular.2528","author":"Eric","year":"2023","journal-title":"Ann Rheumatic Dis"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"5230","DOI":"10.7150\/jca.98688","volume":"15","author":"Li","year":"2024","journal-title":"J Cancer"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.32604\/mcb.2019.07155","author":"Runze","year":"2019","journal-title":"Mol Cell Biomech"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"18679","DOI":"10.1002\/jcp.28508","volume":"234","author":"Zhang","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"114711","DOI":"10.1016\/j.biopha.2023.114711","volume":"162","author":"Song","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"7015","DOI":"10.7150\/thno.45359","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.joca.2021.04.017","volume":"29","author":"Guo","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0834-8","author":"Satoshi","year":"2015","journal-title":"Arthritis Res Therap"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12779","volume":"53","author":"Liang","year":"2020","journal-title":"Cell Proliferation"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e13448","DOI":"10.1111\/cpr.13448","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"7534","DOI":"10.18632\/aging.103109","volume":"12","author":"Bai","year":"2020","journal-title":"Aging"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.joca.2015.09.019","volume":"24","author":"Wang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/1476-4598-13-234","volume":"13","author":"Deng","year":"2014","journal-title":"Mol Cancer"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3171\/spi.2002.97.1.0075","volume":"97","author":"Lu","year":"2002","journal-title":"J Neurosurg"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.actbio.2020.06.008","volume":"113","author":"Tavakoli","year":"2020","journal-title":"Acta Biomater"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"10975","DOI":"10.26355\/eurrev_202011_23581","volume":"24","author":"Yang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1080\/08820139.2023.2205884","volume":"52","author":"Hu","year":"2023","journal-title":"Immunol Invest"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1042\/BST0350652","volume":"35","author":"Le Maitre","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"11977","DOI":"10.18632\/oncotarget.14450","volume":"8","author":"Choi","year":"2017","journal-title":"Oncotarget"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/art.41163","volume":"72","author":"Huang","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"ref58","author":"Z-g","year":"2005","journal-title":"Null"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1006615","author":"Sebastian","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"0801","DOI":"10.1002\/hep.31236","author":"Wei","year":"2020","journal-title":"Hepatology"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.042","author":"Cheng","year":"2023","journal-title":"Bioact. Mater"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101277","author":"Prashanta","year":"2024","journal-title":"Biomolecules"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04824-7","author":"Costanza","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-018-1305-2","author":"Piotr","year":"2018","journal-title":"Protoplasma"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153813","author":"Arianna","year":"2023","journal-title":"Cancers"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518767108","author":"Nisar","year":"2018","journal-title":"J Dental Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.26355\/eurrev_202102_25075","volume":"25","author":"Song","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1093\/humrep\/den025","volume":"23","author":"Morikawa","year":"2008","journal-title":"Hum Reprod"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1097\/bsd.0000000000001601","author":"Umile Giuseppe","year":"2024","journal-title":"Clin Spine Surg a Spine Publication"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-023-07827-w","author":"Kari","year":"2023","journal-title":"Eur Spine J"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59081430","author":"Marcin","year":"2023","journal-title":"Medicina-Lithuania"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.53469\/jcmp.2024.06(10).01","author":"Wei","year":"2024","journal-title":"J. Contemp. Med. Sci"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0000000000001960","author":"\u00c1lvaro","year":"2022","journal-title":"Article Menopause"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050616","author":"Marisa","year":"2020","journal-title":"J Bone Miner Res"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1097\/brs.0000000000001507","volume":"41","author":"W\u00e1ng","year":"2016","journal-title":"Spine"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01427-7","author":"Hao","year":"2017","journal-title":"Sci. Rep"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.joca.2021.11.002","volume":"30","author":"Wang","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00280-x","author":"Huiwen","year":"2023","journal-title":"Bone Res"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13073-022-01088-w","volume":"14","author":"Porcu","year":"2022","journal-title":"Genome Med"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1631\/jzus.B1500048","volume":"16","author":"Zong","year":"2015","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/gepi.20540","volume":"34","author":"Magi","year":"2010","journal-title":"Genet Epidemiol"}],"container-title":["Orthopedic Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111654","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:55:14Z","timestamp":1770184514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multi-omics-bioinformatic-analyses-linking-loxl4-with-spondylolisthesi-peer-reviewed-fulltext-article-ORR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":81,"URL":"https:\/\/doi.org\/10.2147\/orr.s551680","relation":{},"ISSN":["1179-1462"],"issn-type":[{"value":"1179-1462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}