{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:48:50Z","timestamp":1790887730040,"version":"4.1.0"},"reference-count":205,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OTT"],"DOI":"10.2147\/ott.s190753","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T21:08:34Z","timestamp":1592255314000},"page":"5669-5690","source":"Crossref","is-referenced-by-count":89,"title":["&lt;p&gt;Von Hippel-Lindau Disease: Current Challenges and Future Prospects&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Sven","family":"Gl\u00e4sker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelynn","family":"Vergauwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kutikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander O","family":"Vortmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/jmg.28.7.443","volume":"28","author":"Maher","year":"1991","journal-title":"J Med Genet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/0140-6736(91)90401-A","volume":"338","author":"Neumann","year":"1991","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/qjmed\/77.2.1151","volume":"77","author":"Maher","year":"1990","journal-title":"Q J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01994821","volume":"59","author":"von Hippel","year":"1904","journal-title":"Graefes Arch Opthalmol"},{"key":"ref5","first-page":"1","volume":"Suppl 1","author":"Lindau","year":"1926","journal-title":"Acta Path Et Microbiol Scand"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1755-3768.1926.tb07786.x","volume":"4","author":"Lindau","year":"1927","journal-title":"Acta Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3","volume":"8","author":"Zbar","year":"1996","journal-title":"Hum Mutat"},{"key":"ref8","volume-title":"WHO Classification of Tumors of Endocrine Organs","year":"2017"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/humu.21219","volume":"31","author":"Nordstrom-O\u2019Brien","year":"2010","journal-title":"Hum Mutat"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrc885","volume":"2","author":"Kaelin","year":"2002","journal-title":"Nature Reviews Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1073\/pnas.94.6.2156","volume":"94","author":"Pause","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1128\/MCB.18.2.732","volume":"18","author":"Lonergan","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1101\/gad.13.14.1822","volume":"13","author":"Lisztwan","year":"1999","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nm0895-822","volume":"1","author":"Iliopoulos","year":"1995","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1101\/gad.12.2.149","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/path.2062","volume":"210","author":"Vortmeyer","year":"2006","journal-title":"J Pathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/modpathol.2011.61","volume":"24","author":"Shively","year":"2011","journal-title":"Mod Pathol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10595","DOI":"10.1073\/pnas.93.20.10595","volume":"93","author":"Iliopoulos","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/sj.onc.1203938","volume":"19","author":"Krieg","year":"2000","journal-title":"Oncogene"},{"key":"ref24","first-page":"298","volume":"128","author":"Kaelin","year":"2017","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ceb.2007.10.001","volume":"19","author":"Frew","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ncb1699","volume":"10","author":"Young","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1158\/0008-5472.CAN-05-1104","volume":"65","author":"Glasker","year":"2005","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1158\/0008-5472.CAN-05-3505","volume":"66","author":"Glasker","year":"2006","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/ana.20090","volume":"55","author":"Vortmeyer","year":"2004","journal-title":"Ann Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0046-8177(97)90075-7","volume":"28","author":"Vortmeyer","year":"1997","journal-title":"Hum Pathol"},{"key":"ref31","first-page":"504","volume":"58","author":"Lee","year":"1998","journal-title":"Cancer Res"},{"key":"ref32","first-page":"1358","volume":"55","author":"Wizigmann-Voos","year":"1995","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00005072-199605000-00004","volume":"55","author":"Bohling","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2990.2005.00669.x","volume":"31","author":"Hasselblatt","year":"2005","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/path.2435","volume":"216","author":"Shively","year":"2008","journal-title":"J Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3171\/jns.1960.17.4.0751","volume":"17","author":"Stein","year":"1960","journal-title":"J Neurosurg"},{"key":"ref37","first-page":"7051","volume":"63","author":"Vortmeyer","year":"2003","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1371\/journal.pmed.0040060","volume":"4","author":"Park","year":"2007","journal-title":"PLoS Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/path.2062","volume":"210","author":"Vortmeyer","year":"2006","journal-title":"J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archopht.117.5.625","volume":"117","author":"Chan","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s004170050271","volume":"237","author":"Vortmeyer","year":"1999","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/1097-0142(19891201)64:11<2292::AID-CNCR2820641119>3.0.CO;2-#","volume":"64","author":"Heffner","year":"1989","journal-title":"Cancer"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2214\/ajr.159.6.1442389","volume":"159","author":"Choyke","year":"1992","journal-title":"Am J Roentgenol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0046-8177(88)80089-3","volume":"19","author":"Solomon","year":"1988","journal-title":"Hum Pathol"},{"key":"ref45","volume":"154","author":"Walther","year":"1995","journal-title":"J Urol"},{"key":"ref46","first-page":"2089","volume":"149","author":"Lubensky","year":"1996","journal-title":"Am J Pathol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1535-6108(02)00071-5","volume":"1","author":"Mandriota","year":"2002","journal-title":"Cancer Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/path.2029","volume":"210","author":"Glasker","year":"2006","journal-title":"J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1593\/neo.08476","volume":"10","author":"Mehta","year":"2008","journal-title":"Neoplasia"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"630","DOI":"10.5858\/134.4.630","volume":"134","author":"Odrzywolski","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/106689690000800308","volume":"8","author":"Shen","year":"2000","journal-title":"Int J Surg Pathol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajcp\/69.1.289","volume":"69","author":"Compagno","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"ref53","first-page":"951","volume":"151","author":"Vortmeyer","year":"1997","journal-title":"Am J Pathol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0002-9440(10)64799-2","volume":"157","author":"Mohr","year":"1615","journal-title":"Am J Pathol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0002-9440(10)65563-0","volume":"153","author":"Lubensky","year":"1998","journal-title":"Am J Pathol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0046-8177(78)80109-9","volume":"9","author":"Wilson","year":"1978","journal-title":"Hum Pathol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1385\/EP:13:1:17","volume":"13","author":"Koch","year":"2002","journal-title":"Endocr Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","volume":"361","author":"Lonser","year":"2003","journal-title":"Lancet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005792-199711000-00001","volume":"76","author":"Maher","year":"1997","journal-title":"Medicine"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-198901000-00001","volume":"68","author":"Lamiell","year":"1989","journal-title":"Medicine"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11+<2478::AID-CNCR4>3.0.CO;2-5","volume":"86","author":"Friedrich","year":"1999","journal-title":"Cancer"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0161-6420(02)01177-6","volume":"109","author":"Singh","year":"2002","journal-title":"Ophthalmology"},{"key":"ref63","first-page":"47","volume":"5","author":"Schmidt","year":"2000","journal-title":"Eur J Med Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ophtha.2010.04.031","volume":"118","author":"Gaudric","year":"2011","journal-title":"Ophthalmology"},{"key":"ref65","first-page":"495","volume":"103","author":"Chew","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3171\/jns.2003.98.1.0082","volume":"98","author":"Wanebo","year":"2003","journal-title":"J Neurosurg"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3171\/2014.1.JNS131431","volume":"120","author":"Lonser","year":"2014","journal-title":"J Neurosurg"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/ana.20584","volume":"58","author":"Lonser","year":"2005","journal-title":"Ann Neurol"},{"key":"ref69","doi-asserted-by":"crossref","DOI":"10.1227\/NEU.0b013e31828ba793","volume":"72","author":"Glasker","year":"2013","journal-title":"Neurosurgery"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3171\/jns.2003.98.1.0095","volume":"98","author":"Weil","year":"2003","journal-title":"J Neurosurg"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1227\/01.NEU.0000093497.81390.29","volume":"53","author":"van Velthoven","year":"2003","journal-title":"Neurosurgery"},{"key":"ref72","doi-asserted-by":"crossref","DOI":"10.1227\/01.NEU.0000374770.09140.FB","volume":"67","author":"Hwang","year":"2010","journal-title":"Neurosurgery"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3109\/02688697.2013.798863","volume":"27","author":"Benedetto","year":"2013","journal-title":"Br J Neurosurg"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/neuonc\/nop018","volume":"12","author":"Asthagiri","year":"2010","journal-title":"Neuro Oncol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1001\/jama.1997.03540420057030","volume":"277","author":"Manski","year":"1997","journal-title":"JAMA"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jama.298.1.41","volume":"298","author":"Butman","year":"2007","journal-title":"JAMA"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1016\/j.wneu.2013.02.009","volume":"82","author":"Hojo","year":"2014","journal-title":"World Neurosurg"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jocn.2012.12.008","volume":"20","author":"Hao","year":"2013","journal-title":"J Clin Neurosci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000060187","volume":"136","author":"Neumann","year":"2001","journal-title":"Contrib Nephrol"},{"key":"ref80","first-page":"1","volume":"23","author":"Richard","year":"1994","journal-title":"Adv Nephrol Necker Hosp"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/ncpuro0179","volume":"2","author":"Grubb","year":"2005","journal-title":"Nat Clin Pract Urol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"6290S","DOI":"10.1158\/1078-0432.CCR-sup-040025","volume":"10","author":"Kaelin","year":"2004","journal-title":"Clin Cancer Res"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1097\/01.ju.0000096060.92397.ed","volume":"170","author":"Linehan","year":"2003","journal-title":"J Urol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00005392-199501000-00009","volume":"153","author":"Poston","year":"1995","journal-title":"J Urol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0022-5347(05)68930-6","volume":"161","author":"Walther","year":"1999","journal-title":"J Urol"},{"key":"ref86","author":"Jilg","year":"","journal-title":"Urol Int"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"13979","DOI":"10.18632\/oncotarget.14704","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0022-5347(01)67602-X","volume":"153","author":"Walther","year":"1995","journal-title":"J Urol"},{"key":"ref89","author":"Jilg","year":"2012","journal-title":"Fam Cancer"},{"key":"ref90","author":"Allasia","year":"2017","journal-title":"Clin Genitourin Cancer"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1530\/EJE-11-0497","volume":"166","author":"Jafri","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1056\/NEJMoa020152","volume":"346","author":"Neumann","year":"2002","journal-title":"N Engl J Med"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00005392-199909010-00004","volume":"162","author":"Walther","year":"1999","journal-title":"J Urol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1210\/jc.2015-3045","volume":"100","author":"Aufforth","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00268-019-05299-y","volume":"44","author":"Li","year":"2020","journal-title":"World J Surg"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/js.2019-00225","volume":"3","author":"Fagundes","year":"2019","journal-title":"J Endocr Soc"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1530\/ERC-11-0170","volume":"18","author":"Welander","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hed.21790","volume":"34","author":"Papaspyrou","year":"2012","journal-title":"Head Neck"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1210\/jc.2009-1479","volume":"94","author":"Gaal","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1210\/jc.2009-0354","volume":"94","author":"Boedeker","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1365-2265.2008.03256.x","volume":"69","author":"Bhatia","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1373\/clinchem.2010.153320","volume":"57","author":"Eisenhofer","year":"2011","journal-title":"Clin Chem"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1056\/NEJM199906173402404","volume":"340","author":"Eisenhofer","year":"1999","journal-title":"N Engl J Med"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMra1806651","volume":"381","author":"Neumann","year":"2019","journal-title":"N Engl J Med"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ncpendmet1047","volume":"5","author":"Koch","year":"2009","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1210\/jc.2010-1946","volume":"96","author":"Ayala-Ramirez","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"4757","DOI":"10.1210\/jc.2009-1248","volume":"94","author":"Timmers","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1093\/jnci\/djs188","volume":"104","author":"Timmers","year":"2012","journal-title":"JNCI"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1097\/SLA.0000000000002671","volume":"269","author":"Nockel","year":"2019","journal-title":"Ann Surg"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40644-016-0084-2","volume":"16","author":"Chang","year":"2016","journal-title":"Cancer Imaging"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.euf.2015.09.011","volume":"1","author":"Waingankar","year":"2016","journal-title":"Eur Urol Focus"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1210\/jcem.87.5.8446","volume":"87","author":"Weise","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.urology.2017.12.007","volume":"119","author":"Colvin","year":"2018","journal-title":"Urology"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1530\/EJE-09-0399","volume":"161","author":"Gergics","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.surg.2011.09.024","volume":"150","author":"Iacobone","year":"2011","journal-title":"Surgery"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1097\/00000658-200205000-00014","volume":"235","author":"Brunt","year":"2002","journal-title":"Ann Surg"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1210\/jcem.84.8.5872","volume":"84","author":"Neumann","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s00268-002-6632-x","volume":"26","author":"Walz","year":"2002","journal-title":"World J Surg"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"e198898","DOI":"10.1001\/jamanetworkopen.2019.8898","volume":"2","author":"Neumann","year":"2019","journal-title":"JAMA Netw Open"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.jamcollsurg.2010.12.023","volume":"212","author":"Dickson","year":"2011","journal-title":"J Am Coll Surg"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1530\/ERC-13-0415","volume":"21","author":"Bausch","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrendo.2011.132","volume":"7","author":"Singer","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.3390\/cancers11101505","volume":"11","author":"Nolting","year":"2019","journal-title":"Cancers"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0090-4295(97)00074-5","volume":"49","author":"Choyke","year":"1997","journal-title":"Urology"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3109\/00365521.2014.992364","volume":"50","author":"Park","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1097\/MPA.0000000000000875","volume":"46","author":"Sharma","year":"2017","journal-title":"Pancreas"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0016-5085(91)90026-H","volume":"101","author":"Neumann","year":"1991","journal-title":"Gastroenterology"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2214\/ajr.162.5.8165988","volume":"162","author":"Hough","year":"1994","journal-title":"AJR Am J Roentgenol"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jamcollsurg.2013.10.025","volume":"218","author":"Weisbrod","year":"2014","journal-title":"J Am Coll Surg"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1530\/ERC-18-0100","volume":"25","author":"Krauss","year":"2018","journal-title":"Endocr Relat Cancer"},{"key":"ref131","author":"de Mestier","year":"2014","journal-title":"Ann Surg"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1007\/s00259-016-3421-6","volume":"43","author":"Prasad","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1067\/msy.1998.91823","volume":"124","author":"Libutti","year":"1998","journal-title":"Surgery"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1067\/msy.2000.110239","volume":"128","author":"Libutti","year":"2000","journal-title":"Surgery"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00268-010-0878-5","volume":"35","author":"von Ducker","year":"2011","journal-title":"World J Surg"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1136\/jnnp.67.6.758","volume":"67","author":"Glasker","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1093\/brain\/awl362","volume":"130","author":"Woodward","year":"2007","journal-title":"Brain"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13053-017-0084-7","volume":"16","author":"Vergauwen","year":"2018","journal-title":"Hered Cancer Clin Pract"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13053-019-0121-9","volume":"17","author":"Vanbinst","year":"2019","journal-title":"Hered Cancer Clin Pract"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0039-6257(01)00245-4","volume":"46","author":"Singh","year":"2001","journal-title":"Surv Ophthalmol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1136\/jmedgenet-2011-100562","volume":"49","author":"Wilding","year":"2012","journal-title":"J Med Genet"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13023-017-0664-7","volume":"12","author":"Albinana","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1586\/14737140.7.12.1737","volume":"7","author":"George","year":"2007","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref144","first-page":"1","author":"Shepard","year":"2018","journal-title":"J Neurosurg Oct"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1530\/EJE-16-1079","volume":"176","author":"Tirosh","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.yexmp.2017.02.009","volume":"102","author":"Corro","year":"2017","journal-title":"Exp Mol Pathol"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"20058","DOI":"10.18632\/oncotarget.25102","volume":"9","author":"Broncy","year":"2018","journal-title":"Oncotarget"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13053-018-0097-x","volume":"16","author":"Kruger","year":"2018","journal-title":"Hered Cancer Clin Pract"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1182\/blood.V75.3.577.577","volume":"75","author":"Da Silva","year":"1990","journal-title":"Blood"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1200\/JCO.2011.38.6797","volume":"30","author":"Capodimonti","year":"2012","journal-title":"J clin oncol"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N Engl J Med"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1111\/j.1755-3768.2009.01594.x","volume":"88","author":"Ach","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1111\/j.1755-3768.2011.02108.x","volume":"90","author":"Tano","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"66","DOI":"10.2174\/1874364101004010066","volume":"4","author":"Hrisomalos","year":"2010","journal-title":"Open Ophthalmol J"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jcma.2013.09.001","volume":"77","author":"Tsai","year":"2014","journal-title":"J Chin Med Assoc"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3129\/i09-128","volume":"44","author":"Walker","year":"2009","journal-title":"Can J Ophthalmol"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"e271","DOI":"10.1111\/j.1755-3768.2009.01611.x","volume":"88","author":"Wackernagel","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1055\/s-2008-1027175","volume":"225","author":"Michels","year":"2008","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/j.ophtha.2008.04.033","volume":"115","author":"Wong","year":"2008","journal-title":"Ophthalmology"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/IAE.0b013e318030a290","volume":"27","author":"Dahr","year":"2007","journal-title":"Retina"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0161-6420(02)01159-4","volume":"109","author":"Aiello","year":"2002","journal-title":"Ophthalmology"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1182\/blood.V99.10.3851","volume":"99","author":"Richard","year":"2002","journal-title":"Blood"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/S0002-9394(03)00101-6","volume":"136","author":"Girmens","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jama.291.8.943","volume":"291","author":"Madhusudan","year":"2004","journal-title":"JAMA"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1200\/JCO.2005.01.184","volume":"23","author":"Schuch G","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.urolonc.2004.01.011","volume":"22","author":"Jennens","year":"2004","journal-title":"Urol Oncol"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1210\/jc.2008-1972","volume":"94","author":"Jimenez","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1093\/annonc\/mdr011","volume":"22","author":"Jonasch","year":"2011","journal-title":"Ann Oncol"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/MPA.0b013e31822a645e","volume":"41","author":"Ali","year":"2012","journal-title":"Pancreas"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/MCG.0000000000000160","volume":"49","author":"Wang","year":"2015","journal-title":"J Clin Gastroenterol"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10689-014-9771-y","volume":"14","author":"Roma","year":"2015","journal-title":"Fam Cancer"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"629","DOI":"10.2169\/internalmedicine.55.5796","volume":"55","author":"Kobayashi","year":"2016","journal-title":"Intern Med"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"85306","DOI":"10.18632\/oncotarget.13301","volume":"7","author":"Oudard","year":"2016","journal-title":"Oncotarget"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"349","DOI":"10.4143\/crt.2013.45.4.349","volume":"45","author":"Kim","year":"2013","journal-title":"Cancer Res Treat"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.oret.2016.10.007","volume":"1","author":"Knickelbein","year":"2017","journal-title":"Ophthalmol Retina"},{"key":"ref176","first-page":"1","author":"Yuan","year":"2018","journal-title":"Cancer Biol Ther Jun"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"645","DOI":"10.21037\/jgo.2019.01.33","volume":"10","author":"Nunez","year":"2019","journal-title":"J Gastrointest Oncol"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"920","DOI":"10.4103\/0973-1482.162120","volume":"11","author":"Tsimafeyeu","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"ref179","first-page":"517","volume":"36","author":"Babinska","year":"2015","journal-title":"Neuro Endocrinol Lett"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11523-012-0214-0","volume":"7","author":"Kim","year":"2012","journal-title":"Target Oncol"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2217\/cns.15.22","volume":"4","author":"Migliorini","year":"2015","journal-title":"CNS Oncology"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jocn.2018.01.040","volume":"50","author":"Taylor","year":"2018","journal-title":"J Clin Neurosci"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/S1470-2045(18)30487-X","volume":"19","author":"Jonasch","year":"2018","journal-title":"Lancet Oncol"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1177\/1078155219827635","volume":"25","author":"Salim","year":"2019","journal-title":"J Oncol Pharm Pract"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11060-010-0244-3","volume":"101","author":"Rogers","year":"2011","journal-title":"J Neurooncol"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"23390","DOI":"10.18632\/oncotarget.25171","volume":"9","author":"Pilie","year":"2018","journal-title":"Oncotarget"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"E651","DOI":"10.5489\/cuaj.2863","volume":"9","author":"Choi","year":"2015","journal-title":"Can Urol Assoc J"},{"key":"ref188","first-page":"3669","volume":"5","author":"Gross","year":"1999","journal-title":"Clin Cancer Res"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.clon.2004.09.005","volume":"16","author":"Tan","year":"2004","journal-title":"Clin Oncol"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/pbc.22065","volume":"53","author":"Sardi","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"ref191","first-page":"1909","volume":"41","author":"Niemela","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1172\/JCI73665","volume":"125","author":"Metelo","year":"2015","journal-title":"J Clin Invest"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/onc.2017.338","volume":"37","author":"Tarade","year":"2018","journal-title":"Oncogene"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"40822","DOI":"10.1038\/srep40822","volume":"7","author":"Sizdahkhani","year":"2017","journal-title":"Sci Rep"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"e57","DOI":"10.1097\/MPA.0000000000000865","volume":"46","author":"O\u02bcToole","year":"2017","journal-title":"Pancreas"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.12659\/AJCR.907356","volume":"18","author":"Yaghobi Joybari","year":"2017","journal-title":"Am J Case Rep"},{"key":"ref197","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1177\/0300060518792368","volume":"47","author":"Ma","year":"2019","journal-title":"J Int Med Res"},{"key":"ref198","first-page":"4745","volume":"53","author":"Weidmann","year":"1993","journal-title":"Cancer Res"},{"key":"ref199","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13023-015-0343-5","volume":"10","author":"Albinana","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"ref200","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1038\/s41598-019-46448-6","volume":"9","author":"Cuesta","year":"2019","journal-title":"Sci Rep"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.clgc.2018.01.013","volume":"16","author":"Verbiest","year":"2018","journal-title":"Clin Genitourin Cancer"},{"key":"ref202","first-page":"3788","volume":"9","author":"Gross","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref203","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF00941856","volume":"22","author":"Pujol","year":"1995","journal-title":"Eur J Nucl Med"},{"key":"ref204","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2174\/1566524043359827","volume":"4","author":"Maher","year":"2004","journal-title":"Curr Mol Med"},{"key":"ref205","doi-asserted-by":"crossref","unstructured":"Glasker S, Smith J, Raffeld M, Li J, Oldfield EH, Vortmeyer AO. VHL-deficient vasculogenesis in hemangioblastoma. Exp Mol Pathol. 2014;9(2):162\u2013167.","DOI":"10.1016\/j.yexmp.2013.12.011"}],"container-title":["OncoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=58896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=58896","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T12:24:04Z","timestamp":1616243044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/von-hippel-lindau-disease-current-challenges-and-future-prospects-peer-reviewed-article-OTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":205,"URL":"https:\/\/doi.org\/10.2147\/ott.s190753","relation":{},"ISSN":["1178-6930"],"issn-type":[{"value":"1178-6930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}