{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:41:23Z","timestamp":1789771283675,"version":"4.0.1"},"reference-count":47,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OTT"],"DOI":"10.2147\/ott.s264156","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T23:52:16Z","timestamp":1602201136000},"page":"10197-10206","source":"Crossref","is-referenced-by-count":16,"title":["&lt;p&gt;Alternative Treatment Options in Patients with Colorectal Cancer Who Encounter Fluoropyrimidine-Induced Cardiotoxicity&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8154-957X","authenticated-orcid":true,"given":"Muhammad Wasif","family":"Saif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"ref1","first-page":"1","volume":"33","author":"Myers","year":"1981","journal-title":"Pharmacol Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1517\/14740330902733961","volume":"8","author":"Saif","year":"2009","journal-title":"Expert Opin Drug Saf"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1177\/106002809402800314","volume":"28","author":"Anand","year":"1994","journal-title":"Ann Phanrmacother"},{"key":"ref4","first-page":"41","volume":"6","author":"Saif","year":"2008","journal-title":"J Support Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/1097-0142(19931001)72:7<2287::AID-CNCR2820720739>3.0.CO;2-5","volume":"72","author":"Norwood","year":"1993","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-0719-1","volume":"21","author":"Shiga","year":"2020","journal-title":"Curr Treat Options in Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00280-005-0178-1","volume":"58","author":"Jensen","year":"2006","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ejca.2017.02.009","volume":"76","author":"Kwakman","year":"2017","journal-title":"Eur J Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/annonc\/mdf108","volume":"13","author":"Van Cutsem","year":"2002","journal-title":"Ann Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s002800050877","volume":"43","author":"Akpek","year":"1999","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/S0002-9343(88)80268-7","volume":"85","author":"Oleksowicz","year":"1988","journal-title":"Am J Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3109\/02841869009091790","volume":"29","author":"Eskilsson","year":"1990","journal-title":"Acta Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21873\/anticanres.11150","volume":"36","author":"Chen","year":"2016","journal-title":"Anticancer Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e16053e16053","DOI":"10.1200\/JCO.2020.38.15_suppl.e16053","volume":"38","author":"Lopez","year":"2020","journal-title":"JCO"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1056\/NEJMoa1414325","volume":"372","author":"Mayer","year":"2015","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1517\/13543780902729412","volume":"18","author":"Saif","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"key":"ref17","first-page":"625","volume":"31","author":"Saif","year":"2011","journal-title":"Anticancer Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"bcr2016219162","DOI":"10.1136\/bcr-2016-219162","volume":"2017","author":"Franck","year":"2017","journal-title":"BMJ Case Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/jps.2600730217","volume":"73","author":"Yamamoto","year":"1984","journal-title":"J Pharm Sci"},{"key":"ref20","first-page":"1482","volume":"9","author":"Kikuchi","year":"1982","journal-title":"Gan to Kagaku Ryoho"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/bjc.1998.160","volume":"77","author":"K\u00f6hne","year":"1998","journal-title":"Br J Cancer"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf054","volume":"13","author":"Van Cutsem","year":"2002","journal-title":"Ann Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/annonc\/mdt479","volume":"25","author":"Ransom","year":"2014","journal-title":"Ann Oncol"},{"key":"ref24","first-page":"531","volume":"27","author":"Saif","year":"2013","journal-title":"In vivo"},{"key":"ref25","first-page":"821","volume":"23","author":"Shaib","year":"2009","journal-title":"Vivo"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1200\/JCO.2003.08.058","volume":"21","author":"Fuchs","year":"2003","journal-title":"J Clin Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1056\/NEJMoa033025","volume":"351","author":"Cunningham","year":"2004","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1007\/s11523-015-0402-9","volume":"11","author":"Van Cutsem","year":"2016","journal-title":"Target Oncol"},{"key":"ref29","volume":"25","author":"Becouarn","year":"1998","journal-title":"Semin Oncol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000900001","volume":"34","author":"Grivicich","year":"2001","journal-title":"Braz J Med Biol Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.1200\/JCO.2008.17.1249","volume":"26","author":"Haller","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1056\/NEJMoa071834","volume":"357","author":"Jonker","year":"2007","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1200\/JCO.2006.08.1620","volume":"25","author":"Van Cutsem","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0140-6736(12)61900-X","volume":"381","author":"Grothey","year":"2013","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02107","volume":"38","author":"Le","year":"2020","journal-title":"J Clin Oncol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.ejca.2012.01.008","volume":"48","author":"Ferrarotto","year":"2012","journal-title":"Eur J Cancer"},{"key":"ref37","first-page":"2743","volume":"33","author":"Saif","year":"2013","journal-title":"Anticancer Res"},{"key":"ref38","first-page":"23","volume":"2","author":"Ehrlich","year":"2020","journal-title":"Arch Med Case Rep"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120000367","volume":"20","author":"Scheithauer","year":"2002","journal-title":"Cancer Invest"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000055309","volume":"60","author":"Comella","year":"2001","journal-title":"Oncology."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/s12885-016-2409-8","volume":"16","author":"Petrelli","year":"2016","journal-title":"BMC Cancer"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1445-5994.2009.02144.x","volume":"40","author":"Stewart","year":"2010","journal-title":"Intern Med J"},{"key":"ref43","first-page":"e783","volume":"8","author":"Saif","year":"2016","journal-title":"Cureus"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1038\/sj.bjc.6600967","volume":"88","author":"Cianci","year":"2003","journal-title":"Br J Cancer"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/sca.4950230101","volume":"23","author":"Kinhult","year":"2001","journal-title":"Scanning"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1200\/JCO.1989.7.4.509","volume":"7","author":"Rezkalla","year":"1989","journal-title":"J Clin Oncol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/cncr.30321","volume":"123","author":"Ma","year":"2017","journal-title":"Cancer"}],"container-title":["OncoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=62327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=62327","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T23:52:19Z","timestamp":1602201139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/alternative-treatment-options-in-patients-with-colorectal-cancer-who-e-peer-reviewed-article-OTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":47,"URL":"https:\/\/doi.org\/10.2147\/ott.s264156","relation":{},"ISSN":["1178-6930"],"issn-type":[{"value":"1178-6930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}