{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:58:26Z","timestamp":1787763506988,"version":"build-2784847793"},"reference-count":37,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OTT"],"DOI":"10.2147\/ott.s282319","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T23:38:06Z","timestamp":1618789086000},"page":"2727-2739","source":"Crossref","is-referenced-by-count":20,"title":["Exosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p\/TNFRSF1B Pathway"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-5227","authenticated-orcid":true,"given":"Yizhao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9694","DOI":"10.3748\/wjg.v22.i44.9694","volume":"22","author":"Ilic","year":"2016","journal-title":"World J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1007\/s11605-012-1923-5","volume":"16","author":"Peng","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.nut.2016.04.002","volume":"32","author":"Sandini","year":"2016","journal-title":"Nutrition"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/jcsm.12167","volume":"7","author":"von Haehling","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrgastro.2013.49","volume":"10","author":"Sah","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1002\/ijc.27594","volume":"131","author":"Imoto","year":"2012","journal-title":"Int J Cancer"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1079\/PNS19920036","volume":"51","author":"Fearon","year":"1992","journal-title":"Proc Nutr Soc"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e00144","DOI":"10.1002\/phy2.144","volume":"1","author":"Choi","year":"2013","journal-title":"Physiol Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"26041","DOI":"10.18632\/oncotarget.4667","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"ref14","first-page":"679","volume":"7","author":"Bonetto","year":"2016","journal-title":"Front Physiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jconrel.2015.06.029","volume":"219","author":"Milane","year":"2015","journal-title":"J Control Release"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ajpath.2018.10.005","volume":"189","author":"Tesfaye","year":"2019","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.3390\/ijms20184332","volume":"20","author":"Lan","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1158\/1078-0432.CCR-14-2022","volume":"21","author":"Javeed","year":"2015","journal-title":"Clin Cancer Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1136\/gutjnl-2014-308350","volume":"65","author":"Sagar","year":"2016","journal-title":"Gut"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.1038\/s41598-017-05541-4","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41408-018-0139-7","volume":"8","author":"Faict","year":"2018","journal-title":"Blood Cancer J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"13772","DOI":"10.18632\/oncotarget.3830","volume":"6","author":"Raimondi","year":"2015","journal-title":"Oncotarget"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s11658-019-0146-0","volume":"24","author":"Sun","year":"2019","journal-title":"Cell Mol Biol Lett"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1053\/j.gastro.2019.01.259","volume":"156","author":"Singhi","year":"2019","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0206759","DOI":"10.1371\/journal.pone.0206759","volume":"13","author":"Linton","year":"2018","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"30110","DOI":"10.1038\/srep30110","volume":"6","author":"Su","year":"2016","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00281-019-00761-4","volume":"41","author":"Inoue","year":"2019","journal-title":"Semin Immunopathol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1182\/blood-2010-10-311415","volume":"117","author":"Sugatani","year":"2011","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"38491","DOI":"10.1038\/srep38491","volume":"6","author":"Gu","year":"2016","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/hep.26101","volume":"57","author":"Kim","year":"2013","journal-title":"Hepatology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1158\/1078-0432.CCR-10-2132","volume":"17","author":"Nishida","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.18632\/aging.102905","volume":"12","author":"Li","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","volume":"46","author":"Essandoh","year":"2016","journal-title":"Shock"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/ejhf.223","volume":"17","author":"Wong","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s12276-018-0068-3","volume":"50","author":"Cai","year":"2018","journal-title":"Exp Mol Med"}],"container-title":["OncoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68642","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T23:38:09Z","timestamp":1618789089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/exosomes-derived-from-pancreatic-cancer-cells-induce-osteoclast-differ-peer-reviewed-article-OTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":37,"URL":"https:\/\/doi.org\/10.2147\/ott.s282319","relation":{},"ISSN":["1178-6930"],"issn-type":[{"value":"1178-6930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}