{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:08:27Z","timestamp":1749020907971},"reference-count":29,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OTT"],"DOI":"10.2147\/ott.s293901","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:38:59Z","timestamp":1616632739000},"page":"2131-2138","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Novel Alectinib-Resistant ALK Mutation G1202K with Sensitization to Lorlatinib: A Case Report and in silico Structural Modelling"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Ping","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/1759-7714.12613","volume":"9","author":"Du","year":"2018","journal-title":"Thorac Cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nature05945","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1056\/NEJMoa1007478","volume":"363","author":"Choi","year":"2010","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.lungcan.2018.11.024","volume":"127","author":"Yu","year":"2019","journal-title":"Lung Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.lungcan.2020.05.018","volume":"146","author":"Shi","year":"2020","journal-title":"Lung Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1158\/0008-5472.CAN-18-2052","volume":"79","author":"Fukuda","year":"2019","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-016-0251-8","volume":"9","author":"Wu","year":"2016","journal-title":"J Hematol Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"E5381","DOI":"10.1073\/pnas.1515281112","volume":"112","author":"Davare","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1158\/2159-8290.CD-16-1123","volume":"7","author":"Lin","year":"2017","journal-title":"Cancer Discov"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1158\/2159-8290.CD-16-0596","volume":"6","author":"Gainor","year":"2016","journal-title":"Cancer Discov"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.lungcan.2017.05.018","volume":"110","author":"Zhu","year":"2017","journal-title":"Lung Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1056\/NEJMoa1508887","volume":"374","author":"Shaw","year":"2016","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1101\/gr.129684.111","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"\u0160ali","year":"1993","journal-title":"J Mol Biol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1002\/jcc.20290","volume":"26","author":"Case","year":"2005","journal-title":"J Comput Chem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1021\/ci5003203","volume":"54","author":"Cao","year":"2014","journal-title":"J Chem Inf Model"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1021\/ci300302c","volume":"52","author":"Cao","year":"2012","journal-title":"J Chem Inf Model"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1016\/j.cllc.2016.03.005","volume":"17","author":"Lin","year":"2016","journal-title":"Clin Lung Cancer"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1021\/ar000033j","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc Chem Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s42003-018-0075-x","volume":"1","author":"Hauser","year":"2018","journal-title":"Commun Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1021\/acscentsci.8b00717","volume":"4","author":"Aldeghi","year":"2018","journal-title":"ACS Cent Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1021\/acscentsci.9b00590","volume":"5","author":"Aldeghi","year":"2019","journal-title":"ACS Cent Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"10025","DOI":"10.1073\/pnas.1819430116","volume":"116","author":"Ikemura","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1021\/acs.jcim.5b00540","volume":"55","author":"Cao","year":"2015","journal-title":"J Chem Inf Model"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.3389\/fonc.2019.01116","volume":"9","author":"Liu","year":"2019","journal-title":"Front Oncol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1056\/NEJMoa1408440","volume":"371","author":"Solomon","year":"2014","journal-title":"N Engl J Med"}],"container-title":["OncoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67986","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:39:01Z","timestamp":1616632741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/identification-of-novel-alectinib-resistant-alk-mutation-g1202k-with-s-peer-reviewed-article-OTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":29,"URL":"https:\/\/doi.org\/10.2147\/ott.s293901","relation":{},"ISSN":["1178-6930"],"issn-type":[{"value":"1178-6930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}