{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:18:06Z","timestamp":1791519486141,"version":"4.3.4"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OTT"],"DOI":"10.2147\/ott.s527785","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:20:13Z","timestamp":1757499613000},"page":"995-1012","source":"Crossref","is-referenced-by-count":3,"title":["The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-386X","authenticated-orcid":true,"given":"Laura","family":"Solmonese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fortunata","family":"Lofiego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Piazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3358-9327","authenticated-orcid":true,"given":"Emma","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-0922","authenticated-orcid":true,"given":"Fabrizio","family":"Celesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Giacobini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Coral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-2158","authenticated-orcid":true,"given":"Anna Maria","family":"Di Giacomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Covre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"109952","DOI":"10.1016\/j.intimp.2023.109952","volume":"117","author":"Mao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5501\/wjv.v9.i5.67","volume":"9","author":"Dominari","year":"2020","journal-title":"World J Virol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1182\/blood-2003-11-4036","volume":"103","author":"Romani","year":"2004","journal-title":"Blood"},{"key":"ref4","first-page":"1001","volume":"16","author":"Salvati","year":"1996","journal-title":"Anticancer Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1759-7714.2011.00057.x","volume":"2","author":"Jiang","year":"2011","journal-title":"Thorac Cancer"},{"key":"ref6","first-page":"368","volume":"49","author":"Xiong","year":"2019","journal-title":"Ann Clin Lab Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12879-024-08985-y","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1517\/14712598.2015.1033393","volume":"15","author":"Camerini","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1200\/JCO.2009.25.5208","volume":"28","author":"Maio","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1097\/CM9.0000000000001819","volume":"134","author":"Guo","year":"2021","journal-title":"Chin Med J"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ijrobp.2022.07.009","volume":"114","author":"Liu","year":"2022","journal-title":"Int J Radiat Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1517\/14712598.2015.1008446","volume":"15","author":"King","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e202000662","DOI":"10.26508\/lsa.202000662","volume":"3","author":"Renga","year":"2020","journal-title":"Life Sci Alliance"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/14712598.2018.1494717","volume":"18","author":"Danielli","year":"2018","journal-title":"Expert Opin Biol Ther"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3389\/fonc.2019.00873","volume":"9","author":"Costantini","year":"2019","journal-title":"Front Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.canlet.2006.05.019","volume":"248","author":"Li","year":"2007","journal-title":"Cancer Lett"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s10495-015-1138-9","volume":"20","author":"Guo","year":"2015","journal-title":"Apoptosis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bbrc.2015.06.132","volume":"464","author":"Yuan","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"110740","DOI":"10.1016\/j.biopha.2020.110740","volume":"131","author":"Yang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref20","first-page":"3343","volume":"53","author":"Altomonte","year":"1993","journal-title":"Cancer Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1158\/1078-0432.CCR-06-3091","volume":"13","author":"Fonsatti","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.4049\/jimmunol.163.12.6867","volume":"163","author":"Kammula","year":"1999","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/s0165-2478(96)02687-9","volume":"55","author":"Correale","year":"1997","journal-title":"Immunol Lett"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/302084","volume":"2009","author":"Sungarian","year":"2009","journal-title":"J Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s10495-015-1151-z","volume":"20","author":"Lao","year":"2015","journal-title":"Apoptosis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3972","DOI":"10.3390\/cancers14163972","volume":"14","author":"Peterson","year":"2022","journal-title":"Cancers"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"868695","DOI":"10.3389\/fphar.2022.868695","volume":"13","author":"Kim","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/14712598.2018.1456527","volume":"18","author":"Mandaliti","year":"2018","journal-title":"Expert Opin Biol Ther"},{"key":"ref31","doi-asserted-by":"publisher","volume-title":"Vitamins and Hormones","year":"2016","DOI":"10.1016\/bs.vh.2016.04.003"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12967-024-05040-x","volume":"22","author":"Lofiego","year":"2024","journal-title":"J Transl Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1038\/s41467-023-40994-4","volume":"14","author":"Noviello","year":"2023","journal-title":"Nat Commun"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.08.2288","author":"Di Giacomo","year":"2024","journal-title":"Ann Oncol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13046-022-02251-2","volume":"41","author":"Bausart","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1333661","DOI":"10.3389\/fimmu.2023.1333661","volume":"14","author":"Calabr\u00f2","year":"2024","journal-title":"Front Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/1521-4141(200003)30:3<778::AID-IMMU778>3.0.CO;2-I","volume":"30","author":"Giuliani","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1749-6632.2012.06697.x","volume":"1269","author":"Garaci","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.canlet.2014.10.002","volume":"356","author":"Ni","year":"2015","journal-title":"Cancer Lett"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF00916574","volume":"4","author":"Ershler","year":"1984","journal-title":"J Clin Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0192-0561(85)90065-7","volume":"7","author":"Ershler","year":"1985","journal-title":"Int J Immunopharmacol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41571-022-00619-z","volume":"19","author":"Fridman","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1517\/14712598.2015.1021677","volume":"15","author":"Matteucci","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1749-6632.2010.05484.x","volume":"1194","author":"Matteucci","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/14712598.2018.1474198","volume":"18","author":"Matteucci","year":"2018","journal-title":"Expert Opin Biol Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06716.x","volume":"1269","author":"Romani","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/0192-0561(94)90081-7","volume":"16","author":"Eckert","year":"1994","journal-title":"Int J Immunopharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S1567-5769(03)00053-5","volume":"3","author":"Garaci","year":"2003","journal-title":"Int Immunopharmacol"}],"container-title":["OncoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106806","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:20:15Z","timestamp":1757499615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-immunomodulatory-activity-of-thymosin-alpha-1-on-tumor-cell-lines--peer-reviewed-fulltext-article-OTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/ott.s527785","relation":{},"ISSN":["1178-6930"],"issn-type":[{"value":"1178-6930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}