{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:22:30Z","timestamp":1791426150783,"version":"4.3.3"},"reference-count":88,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PPA"],"DOI":"10.2147\/ppa.s221882","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:30:40Z","timestamp":1653309040000},"page":"1307-1319","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Evaluation of Siponimod for the Treatment of Secondary Progressive Multiple Sclerosis: Pathophysiology, Efficacy, Safety, Patient Acceptability and Adherence"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Sajida","family":"Sabsabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Mikhael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Jalkh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-2332","authenticated-orcid":true,"given":"Gabrielle","family":"Macaron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-8394","authenticated-orcid":true,"given":"Mary","family":"Rensel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2217\/cer-2019-0169","volume":"9","author":"Swallow","year":"2020","journal-title":"J Comp Eff Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1056\/nejm199801293380502","volume":"338","author":"Trapp","year":"1998","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/ana.24747","volume":"80","author":"Cree","year":"2016","journal-title":"Ann Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1191\/1352458503ms914oa","volume":"9","author":"Eriksson","year":"2003","journal-title":"Mult Scler J"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/brain\/awl007","volume":"129","author":"Confavreux","year":"2006","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1212\/WNL.0000000000000560","volume":"83","author":"Lublin","year":"2014","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1001\/jama.2018.20588","volume":"321","author":"Brown","year":"2019","journal-title":"J Am Med Assoc"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e1041","DOI":"10.1212\/WNL.0000000000010135","volume":"95","author":"Buron","year":"2020","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1001\/jamaneurol.2021.2738","volume":"78","author":"Spelman","year":"2021","journal-title":"JAMA Neurol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"175628642110195","DOI":"10.1177\/17562864211019574","volume":"14","author":"Iaffaldano","year":"2021","journal-title":"Ther Adv Neurol Disord"},{"key":"ref12","volume":"90","author":"Khurana","year":"2018","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1093\/brain\/aww173","volume":"139","author":"Lorscheider","year":"2016","journal-title":"Brain"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1177\/1352458514521517","volume":"20","author":"Sand","year":"2014","journal-title":"Mult Scler J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1001\/jamaneurol.2020.1568","volume":"77","author":"Kappos","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.7224\/1537-2073.2015-062","volume":"18","author":"Davies","year":"2016","journal-title":"Int J MS Care"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/WCO.0000000000000094","volume":"27","author":"Dutta","year":"2014","journal-title":"Curr Opin Neurol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/ana.25463","volume":"85","author":"Cree","year":"2019","journal-title":"Ann Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"457","DOI":"10.5750\/ejpch.v1i2.687","volume":"1","author":"Deibel","year":"2013","journal-title":"Eur J Pers Centered Healthc"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1177\/1352458517729768","volume":"23","author":"Fox","year":"2017","journal-title":"Mult Scler"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1177\/1352458518800800","volume":"24","author":"Mills","year":"2018","journal-title":"Mult Scler J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1177\/1352458517729460","volume":"23","author":"Tur","year":"2017","journal-title":"Mult Scler"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1177\/1352458517729465","volume":"23","author":"Ontaneda","year":"2017","journal-title":"Mult Scler"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.msard.2017.01.007","volume":"12","author":"Giovannoni","year":"2017","journal-title":"Mult Scler Relat Disord"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1352458517751049","volume":"24","author":"Montalban","year":"2018","journal-title":"Mult Scler"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1212\/WNL.0000000000005347","volume":"90","author":"Rae-Grant","year":"2018","journal-title":"Neurology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/S1474-4422(18)30248-5","volume":"17","author":"Macaron","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/S40263-015-0261-Z","volume":"29","author":"Subei","year":"2015","journal-title":"CNS Drugs"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/cells8010024","volume":"8","author":"Behrangi","year":"2019","journal-title":"Cells"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1021\/ml300396r","volume":"4","author":"Pan","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.3390\/cells9081771","volume":"9","author":"Kipp","year":"2020","journal-title":"Cells"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1124\/jpet.103.062828","volume":"309","author":"Forrest","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.msard.2014.05.005","volume":"3","author":"Dimarco","year":"2014","journal-title":"Mult Scler Relat Disord"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1756286419878323","volume":"12","author":"Faissner","year":"2019","journal-title":"Ther Adv Neurol Disord"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1136\/jnnp-2013-307282","volume":"85","author":"Olsson","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00635","volume":"11","author":"Colombo","year":"2020","journal-title":"Front Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/S0140-6736(18)30475-6","volume":"391","author":"Kappos","year":"2018","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e19598","DOI":"10.2196\/19598","volume":"9","author":"Ziemssen","year":"2020","journal-title":"JMIR Res Protoc"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e376","DOI":"10.1212\/WNL.0000000000011275","volume":"96","author":"Benedict","year":"2021","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S0140-6736(15","volume":"387","author":"Lublin","year":"2016","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1080\/03007995.2021.1968362","volume":"37","author":"Samjoo","year":"2021","journal-title":"Curr Med Res Opin"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.17925\/ENR.2018.13.1.25","volume":"13","author":"Vermersch","year":"2017","journal-title":"Eur Neurol Rev"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.clinthera.2016.01.021","volume":"38","author":"Legangneux","year":"2016","journal-title":"Clin Ther"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S1474-4422(13","volume":"12","author":"Selmaj","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"135245852110613","DOI":"10.1177\/13524585211061343","author":"Cohen","year":"2022","journal-title":"Mult Scler J"},{"key":"ref46","unstructured":"Full prescribing information 1 indications and usage Gilenya; 2012. Available from: https:\/\/www.novartis.us\/sites\/www.novartis.us\/files\/gilenya.pdf. Accessed May 5, 2022."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1007\/s00415-019-09690-6","volume":"268","author":"Schweitzer","year":"2021","journal-title":"J Neurol"},{"key":"ref48","unstructured":"Novartis Pharmaceuticals Corporation. MAYZENT\u00ae (siponimod). Mayzent FDA label; 2019. Available from: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/209884s000lbl.pdf. Accessed May 5, 2022."},{"key":"ref49","unstructured":"Highlights of prescribing information. Metabolism: Clinical and Experimental; 2008. Available from: www.fda.gov\/. Accessed February 8, 2022."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/vaccines9010012","volume":"9","author":"Jalkh","year":"2021","journal-title":"Vaccines"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s40262-018-0700-3","volume":"58","author":"Gardin","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/cpt.1547","volume":"106","author":"Huth","year":"2019","journal-title":"Clin Pharmacol Ther"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"100346","DOI":"10.1016\/j.ensci.2021.100346","volume":"23","author":"Senzaki","year":"2021","journal-title":"eNeurologicalSci"},{"key":"ref54","unstructured":"Canadian Agency for Drugs and Technologies in Health (CADTH). Drug reimbursement recommendation siponimod (Mayzent). Canada; 2019."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e1870","DOI":"10.1212\/wnl.0000000000012753","volume":"97","author":"Simpson-Yap","year":"2021","journal-title":"Neurology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e1092","DOI":"10.1212\/nxi.0000000000001092","volume":"9","author":"Sullivan","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"103435","DOI":"10.1016\/j.msard.2021.103435","volume":"57","author":"Skoric","year":"2020","journal-title":"Mult Scler Relat Disord J"},{"key":"ref58","unstructured":"National Multiple Sclerosis Society. COVID-19 vaccine guidance for people living with MS; 2021. Available from: https:\/\/www.nationalmssociety.org\/coronavirus-covid-19-information\/multiple-sclerosis-and-coronavirus\/covid-19-vaccine-guidance. Accessed January 29, 2022."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40273-021-01023-8","volume":"39","author":"Schur","year":"2021","journal-title":"Pharmacoeconomics"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/psb.1882","volume":"31","author":"Chaplin","year":"2020","journal-title":"NICE"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.2147\/PPA.S175095","volume":"12","author":"Ko\u0142tuniuk","year":"2018","journal-title":"Patient Prefer Adherence"},{"key":"ref62","first-page":"e3776","volume":"4","author":"Deshpande","year":"2015","journal-title":"Interact J Med Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12883-020-01830-0","volume":"20","author":"Nicholas","year":"2020","journal-title":"BMC Neurol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pediatrneurol.2009.03.004","volume":"41","author":"Thannhauser","year":"2009","journal-title":"Pediatr Neurol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/pds.1593","volume":"17","author":"Tremlett","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1177\/1352458516657440","volume":"23","author":"McKay","year":"2017","journal-title":"Mult Scler"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"287","DOI":"10.7224\/1537-2073.2017-070","volume":"20","author":"Ben-Zacharia","year":"2018","journal-title":"Int J MS Care"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1177\/0272989X19897944","volume":"40","author":"Jonker","year":"2020","journal-title":"Med Decis Mak"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.2147\/PPA.S114619","volume":"10","author":"Garcia-Dominguez","year":"2016","journal-title":"Patient Prefer Adherence"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2217\/nmt-2020-0034","volume":"10","author":"Bauer","year":"2020","journal-title":"Neurodegener Dis Manag"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/0272989X17724434","volume":"38","author":"Col","year":"2018","journal-title":"Med Decis Mak"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"e014433","DOI":"10.1136\/bmjopen-2016-014433","volume":"7","author":"Arroyo","year":"2017","journal-title":"BMJ Open"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1080\/13696998.2017.1336099","volume":"20","author":"Bottomley","year":"2017","journal-title":"J Med Econ"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.2196\/ijmr.3776","volume":"4","author":"Wicks","year":"2015","journal-title":"Interact J Med Res"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1007\/s00415-018-8831-x","volume":"265","author":"Lanzillo","year":"2018","journal-title":"J Neurol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.msard.2016.09.011","volume":"10","author":"Moccia","year":"2016","journal-title":"Mult Scler Relat Disord"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s40263-017-0412-5","volume":"31","author":"van Munster","year":"2017","journal-title":"CNS Drugs"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/S12325-019-00958-X","volume":"36","author":"Rhodes","year":"2019","journal-title":"Adv Ther"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/BRB3.875","volume":"8","author":"H\u00f8jsgaard Chow","year":"2018","journal-title":"Brain Behav"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Kappos L, Vermersch P, Cree B, et al. A novel functional composite endpoint to characterize disease progression in patients with secondary progressive multiple sclerosis (S12.006); 2019.","DOI":"10.1212\/WNL.92.15_supplement.S12.006"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1212\/CPJ.0000000000000710","volume":"10","author":"Macaron","year":"2020","journal-title":"Neurol Clin Pract"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/S00115-011-3376-6","volume":"83","author":"Schulthei\u00df","year":"2012","journal-title":"Nervenarzt"},{"key":"ref83","unstructured":"Schulze-Topphoff U. PANGAEA 2.0 EVOLUTION: state of the art multiple sclerosis patient. ECTRIMS Online Library; 2019 Nov 30-1: 279599. Available from: https:\/\/onlinelibrary.ectrims-congress.eu\/ectrims\/2019\/stockholm\/279599\/ulf.schulzetopphoff.pangaea.2.0.evolution.state.of.the.art.multiple.sclerosis.html. Accessed December 7, 2021."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s40120-020-00224-1","volume":"10","author":"Neuberger","year":"2021","journal-title":"Neurol Ther"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2017.00317","volume":"10","author":"Quarta","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-3-319-05879-5_4","volume":"378","author":"Xiong","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1073\/pnas.1618659114","volume":"114","author":"Yanagida","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/09273948.2019.1576910","volume":"27","author":"Accorinti","year":"2019","journal-title":"Ocul Immunol Inflamm"}],"container-title":["Patient Preference and Adherence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80993","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:41:58Z","timestamp":1727278918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/clinical-evaluation-of-siponimod-for-the-treatment-of-secondary-progre-peer-reviewed-fulltext-article-PPA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":88,"URL":"https:\/\/doi.org\/10.2147\/ppa.s221882","relation":{},"ISSN":["1177-889X"],"issn-type":[{"value":"1177-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}