{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:19:40Z","timestamp":1783563580041,"version":"3.55.0"},"reference-count":69,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PPA"],"DOI":"10.2147\/ppa.s244273","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T02:20:42Z","timestamp":1586917242000},"page":"737-746","source":"Crossref","is-referenced-by-count":55,"title":["&lt;p&gt;Metformin Improves the Depression Symptoms of Women with Polycystic Ovary Syndrome in a Lifestyle Modification Program&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Fatimah","family":"AlHussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-5924","authenticated-orcid":true,"given":"Yazed","family":"AlRuthia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Al-Mandeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa","family":"Bellahwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-6986","authenticated-orcid":true,"given":"Yasser","family":"Almogbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Awwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roua","family":"Dala'een","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-7985","authenticated-orcid":true,"given":"Fawaz Abdullah","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"786362","DOI":"10.1155\/2015\/786362","volume":"2015","author":"Baldani","year":"2015","journal-title":"Int J Endocrinol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet (London, England)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil Steril"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/CLEP.S37559","volume":"6","author":"Sirmans","year":"2013","journal-title":"Clin Epidemiol"},{"key":"ref5","first-page":"30","volume":"44","author":"Pfieffer","year":"2019","journal-title":"Clin Med Res"},{"key":"ref6","first-page":"279","volume":"80","author":"Ali","year":"2015","journal-title":"Ceska Gynekol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1210\/jc.2005-2153","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1210\/jc.2005-2501","volume":"91","author":"Franks","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/humupd\/dmy022","volume":"24","author":"Skiba","year":"2018","journal-title":"Hum Reprod Update"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jmau.2013.06.002","volume":"1","author":"Guraya","year":"2013","journal-title":"J Microsc Ultrastruct"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.29121\/granthaalayah.v6.i9.2018.1252","volume":"6","author":"Al Bassam","year":"2018","journal-title":"Int J Res Granthaalayah"},{"key":"ref12","first-page":"238","volume":"62","author":"Mehrabian","year":"2011","journal-title":"Endokrynol Pol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"96351","DOI":"10.18632\/oncotarget.19180","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1080\/09513590600604541","volume":"22","author":"Coffey","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1093\/humrep\/dem108","volume":"22","author":"Barnard","year":"2007","journal-title":"Hum Reprod"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.fertnstert.2011.05.072","volume":"96","author":"Li","year":"2011","journal-title":"Fertil Steril"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/humrep\/der071","volume":"26","author":"Deeks","year":"2011","journal-title":"Hum Reprod"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11920-017-0834-2","volume":"19","author":"Cooney","year":"2017","journal-title":"Curr Psychiatry Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/IJPSYM.IJPSYM_561_17","volume":"40","author":"Chaudhari","year":"2018","journal-title":"Indian J Psychol Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3109\/09513590.2013.852530","volume":"30","author":"Farkas","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e97041","DOI":"10.1371\/journal.pone.0097041","volume":"9","author":"Hung","year":"2014","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.neuropharm.2017.11.038","volume":"136","author":"Watson","year":"2018","journal-title":"Neuropharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.31887\/DCNS.2018.20.1\/nsartorius","volume":"20","author":"Sartorius","year":"2018","journal-title":"Dialogues Clin Neurosci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2147\/TCRM.S6864","volume":"4","author":"Mathur","year":"2008","journal-title":"Ther Clin Risk Manag"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"j138","DOI":"10.1136\/bmj.j138","volume":"356","author":"Wang","year":"2017","journal-title":"bmj"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/aogs.12673","volume":"94","author":"Abu Hashim","year":"2015","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2008-0030","volume":"30","author":"Palomba","year":"2009","journal-title":"Endocr Rev"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3109\/09513590903215581","volume":"26","author":"Fux Otta","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.diabres.2017.06.011","volume":"130","author":"Macut","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1477-7827-12-98","volume":"12","author":"Kurzthaler","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"394623","DOI":"10.1155\/2012\/394623","volume":"2012","author":"Castro Cabezas","year":"2012","journal-title":"J Nutr Metab"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.psyneuen.2012.08.010","volume":"38","author":"Kashani","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"E55","DOI":"10.1542\/peds.107.4.e55","volume":"107","author":"Freemark","year":"2001","journal-title":"Pediatrics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/1440-1681.12265","volume":"41","author":"Guo","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2017.08.019","volume":"1674","author":"Shivavedi","year":"2017","journal-title":"Brain Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00210-018-1466-8","volume":"391","author":"Khedr","year":"2018","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/humrep\/del069","volume":"21","author":"Hahn","year":"2006","journal-title":"Hum Reprod"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1093\/humrep\/des310","volume":"27","author":"Moll","year":"2012","journal-title":"Hum Reprod"},{"key":"ref40","volume-title":"Reprod Med","year":"2016"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"E2107","DOI":"10.1210\/jc.2014-1084","volume":"99","author":"Louwers","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bpobgyn.2016.04.001","volume":"37","author":"Huang","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/humrep\/dew287","volume":"32","author":"Wang","year":"2017","journal-title":"Hum Reprod"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1365-2125.2004.02103.x","volume":"57","author":"Carlson","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31887\/DCNS.2008.10.4\/jlenze","volume":"10","author":"Lenze","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12991-017-0155-1","volume":"16","author":"AlHadi","year":"2017","journal-title":"Ann Gen Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.psychres.2016.03.030","volume":"239","author":"Sawaya","year":"2016","journal-title":"Psychiatry Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/00005650-199803000-00018","volume":"36","author":"Coons","year":"1998","journal-title":"Med Care"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.sapharm.2015.02.002","volume":"11","author":"Al-Jumaili","year":"2015","journal-title":"Res Social Adm Pharm"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2296-7-21","volume":"7","author":"Morris","year":"2006","journal-title":"BMC Fam Pract"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","volume":"16","author":"Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"317","DOI":"10.7326\/0003-4819-146-5-200703060-00004","volume":"146","author":"Kroenke","year":"2007","journal-title":"Ann Intern Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jdiacomp.2017.01.013","volume":"31","author":"Wang","year":"2017","journal-title":"J Diabetes Complications"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.pharep.2016.12.004","volume":"69","author":"Aswar","year":"2017","journal-title":"Pharmacol Rep PR"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.psyneuen.2018.05.010","volume":"94","author":"Moulton","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11126-016-9436-0","volume":"88","author":"Tu","year":"2017","journal-title":"Psychiatr Q"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12038-016-9627-8","volume":"41","author":"Reddy","year":"2016","journal-title":"J Biosci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/09513590.2018.1498476","volume":"35","author":"Erensoy","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.psyneuen.2008.12.001","volume":"34","author":"Benson","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"655","DOI":"10.2147\/NDT.S25504","volume":"7","author":"Kawamura","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.psyneuen.2017.08.007","volume":"85","author":"Cesta","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e1007813","DOI":"10.1371\/journal.pgen.1007813","volume":"14","author":"Day","year":"2018","journal-title":"PLoS Genet"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/bs.apha.2018.04.005","volume":"83","author":"Srinivasan","year":"2018","journal-title":"Adv Pharmacol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e0178120","DOI":"10.1371\/journal.pone.0178120","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/j.1365-2265.2010.03873.x","volume":"73","author":"Glintborg","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1210\/jc.2006-1191","volume":"91","author":"Welt","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"655","DOI":"10.2217\/epi-2018-0187","volume":"11","author":"Wang","year":"2019","journal-title":"Epigenomics"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuro.2019.02.004","volume":"72","author":"Keshavarzi","year":"2019","journal-title":"Neurotoxicol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1371\/journal.pmed.0050067","volume":"5","author":"Vandenbroucke","year":"2008","journal-title":"PLoS Med"}],"container-title":["Patient Preference and Adherence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57409","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:21:10Z","timestamp":1722730870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/metformin-improves-the-depression-symptoms-of-women-with-polycystic-ov-peer-reviewed-article-PPA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":69,"URL":"https:\/\/doi.org\/10.2147\/ppa.s244273","relation":{},"ISSN":["1177-889X"],"issn-type":[{"value":"1177-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}