{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:41:15Z","timestamp":1790559675449,"version":"4.1.0"},"reference-count":42,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PPA"],"DOI":"10.2147\/ppa.s253732","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T21:13:41Z","timestamp":1591132421000},"page":"917-926","source":"Crossref","is-referenced-by-count":47,"title":["<p>Applying Machine Learning Models to Predict Medication Nonadherence in Crohn\u2019s Disease Maintenance Therapy<\/p>"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-5003","authenticated-orcid":true,"given":"Liwen","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/s41395-018-0120-x","volume":"113","author":"Lichtenstein","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1524-4733.2007.00213.x","volume":"11","author":"Cramer","year":"2008","journal-title":"Value Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4292\/wjgpt.v8.i2.114","volume":"8","author":"Actis","year":"2017","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/ajg.2009.685","volume":"105","author":"Jackson","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/j.1572-0241.2003.07522.x","volume":"98","author":"Sewitch","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1111\/jgh.14258","volume":"33","author":"Woo","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0145076","DOI":"10.1371\/journal.pone.0145076","volume":"10","author":"Depont","year":"2015","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/17474124.2017.1284587","volume":"11","author":"Lenti","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/jcpt.12830","volume":"44","author":"Khan","year":"2019","journal-title":"J Clin Pharm Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1053\/j.gastro.2012.10.003","volume":"144","author":"Bonaz","year":"2013","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"109665","DOI":"10.1016\/j.mehy.2020.109665","volume":"140","author":"Colonnello","year":"2020","journal-title":"Med Hypotheses"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.compbiomed.2019.04.017","volume":"109","author":"Almansour","year":"2019","journal-title":"Comput Biol Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1472-6947-10-16","volume":"10","author":"Yu","year":"2010","journal-title":"BMC Med Inform Decis Mak"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4258\/hir.2010.16.4.253","volume":"16","author":"Son","year":"2010","journal-title":"Healthc Inform Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e17510","DOI":"10.1097\/MD.0000000000017510","volume":"98","author":"Dong","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s00384-015-2250-6","volume":"30","author":"Peng","year":"2015","journal-title":"Int J Colorectal Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1093\/ecco-jcc\/jjx014","volume":"11","author":"Waljee","year":"2017","journal-title":"J Crohns Colitis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12876-019-1057-2","volume":"19","author":"Li","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/ibd.20846","volume":"15","author":"Horne","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/08870440290001502","volume":"17","author":"Horne","year":"2002","journal-title":"Psychol Health"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1097\/MIB.0000000000001201","volume":"23","author":"Severs","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/00365521.2017.1405070","volume":"53","author":"Ribaldone","year":"2018","journal-title":"Scand J Gastroenterol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1185\/03007990903126833","volume":"25","author":"Karve","year":"2009","journal-title":"Curr Med Res Opin"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1097\/MIB.0000000000000853","volume":"22","author":"Severs","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1097\/MIB.0000000000001194","volume":"23","author":"Tiao","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08870449908407311","volume":"14","author":"Horne","year":"1999","journal-title":"Psychol Health"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2105-8-25","volume":"8","author":"Strobl","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"ref29","unstructured":"Predictor importance estimates by permutation of out-of-bag predictor observations for random forest of classification trees. Available from: https:\/\/www.mathworks.com\/help\/stats\/classificationbaggedensemble.oobpermutedpredictorimportance.html#bvgfu5_. Accessed May 15, 2020."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/j.1553-2712.2011.01185.x","volume":"18","author":"Stoltzfus","year":"2011","journal-title":"Acad Emerg Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1109\/MASSP.1987.1165576","volume":"4","author":"Lippmann","year":"1987","journal-title":"IEEE ASSP Mag"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11119-014-9370-9","volume":"16","author":"Yang","year":"2015","journal-title":"Precis Agric"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1109\/TKDE.2005.50","volume":"17","author":"Huang","year":"2005","journal-title":"IEEE Trans Knowl Data Eng"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","volume":"87","author":"Neuendorf","year":"2016","journal-title":"J Psychosom Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1126\/science.3287615","volume":"240","author":"Swets","year":"1988","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1007\/s10620-014-3471-1","volume":"60","author":"Tabibian","year":"2015","journal-title":"Dig Dis Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11136-017-1702-6","volume":"27","author":"Varni","year":"2018","journal-title":"Qual Life Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/MEG.0000000000000570","volume":"28","author":"Coenen","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/ajg.2016.98","volume":"111","author":"Gaines","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12325-016-0441-3","volume":"34","author":"Michetti","year":"2017","journal-title":"Adv Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1097\/MEG.0000000000001436","volume":"31","author":"Bruna-Barranco","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7847123","DOI":"10.1155\/2019\/7847123","volume":"2019","author":"Agostini","year":"2019","journal-title":"Gastroenterol Res Pract"}],"container-title":["Patient Preference and Adherence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=58592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=58592","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T21:13:45Z","timestamp":1591132425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/applying-machine-learning-models-to-predict-medication-nonadherence-in-peer-reviewed-article-PPA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2147\/ppa.s253732","relation":{},"ISSN":["1177-889X"],"issn-type":[{"value":"1177-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}