{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:38:16Z","timestamp":1766579896598,"version":"3.40.5"},"reference-count":55,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TCRM"],"DOI":"10.2147\/tcrm.s228880","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:22:50Z","timestamp":1586996570000},"page":"287-297","source":"Crossref","is-referenced-by-count":6,"title":["<p>Therapeutic Potential of Ixekizumab in the Treatment of Ankylosing Spondylitis: A Review on the Emerging Clinical Data<\/p>"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Maurizio","family":"Benucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Damiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-0930","authenticated-orcid":true,"given":"Francesca","family":"Li Gobbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Infantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Niccoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-043X","authenticated-orcid":true,"given":"Fabrizio","family":"Cantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0140-6736(16)31591-4","volume":"390","author":"Sieper","year":"2017","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"vi4","DOI":"10.1093\/rheumatology\/key001","volume":"57","author":"Simone","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/acr2.11044","volume":"1","author":"Khan","year":"2019","journal-title":"ACR Open Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"Van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1002\/art.21054","volume":"52","author":"Wanders","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/s12891-016-1275-5","volume":"17","author":"Balazcs","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/acr.v67.8","volume":"67","author":"Kristensen","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.berh.2018.12.001","volume":"32","author":"Lories","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/2040622317743486","volume":"9","author":"Dubash","year":"2018","journal-title":"Ther Adv Chronic Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1002\/art.38070","volume":"65","author":"Haroon","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/14740338.2016.1240783","volume":"15","author":"Minozzi","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.cmi.2017.12.025","volume":"24","author":"Baddley","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/s41584-018-0044-2","volume":"14","author":"Taams","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s40265-019-01075-3","volume":"79","author":"Blair","year":"2019","journal-title":"Drugs"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.2217\/imt-2019-0094","volume":"11","author":"Kiwalkar","year":"2019","journal-title":"Immunotherapy"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0889-857X(21)00705-5","volume":"18","author":"Benjamin","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng.2007.17","volume":"39","author":"Burton","year":"2007","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/eji.200635997","volume":"37","author":"Kollnberger","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/ar2936","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/cdd.2009.74","volume":"16","author":"Huang","year":"2009","journal-title":"Cell Death Differ"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e40044","DOI":"10.1371\/journal.pone.0040044","volume":"7","author":"Nam","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.archoralbio.2014.05.009","volume":"59","author":"Kim","year":"2014","journal-title":"Arch Oral Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1136\/annrheumdis-2019-215356","volume":"78","author":"McGonagle","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/ICU.0000000000000466","volume":"29","author":"Weinstein","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1002\/art.39732","volume":"68","author":"Reinhardt","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.berh.2018.07.007","volume":"31","author":"Lories","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.immuni.2015.09.003","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1136\/annrheumdis-2015-208902","volume":"75","author":"Gracey","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1136\/annrheumdis-2014-206323","volume":"74","author":"Ciccia","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"ref31","unstructured":"European Medicine Agency. EMEA\/H\/C\/003729. Cosentyx: EPAR \u2013 Summary for the public. March 2, 2015. Available fom: https:\/\/www.ema.europa.eu\/en\/documents\/overview\/cosentyx-epar-summary-public_en.pdf. Accessed December 4, 2019."},{"key":"ref32","unstructured":"Novartis receives two new FDA approvals for Cosentyx to treat patients with ankylosing spondylitis and psoriatic arthritis in the US. Jan 15, 2016. Available fom: https:\/\/novartis.gcs-web.com\/novartis-receives-fda-approvals-for-secukinumab-in-as-and-psa. Accessed December 5, 2019."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s40265-016-0598-8","volume":"76","author":"Blair","year":"2016","journal-title":"Drugs"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"8909834","DOI":"10.1155\/2017\/8909834","volume":"2017","author":"Cantini","year":"2017","journal-title":"Mediators Inflamm"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/mi.2017.97","volume":"11","author":"Li","year":"2018","journal-title":"Mucosal Immunol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/art.41169","author":"Manasson","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/j.cmi.2018.02.002","volume":"24 Suppl 2","author":"Winthrop","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/apt.15397","volume":"50","author":"Yamada","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"ref39","unstructured":"European Medicine Agency. EMEA\/H\/C\/003943. Taltz: EPAR summary for the public. April 25, 2016. updated August 28, 2019. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/overview\/taltz-epar-summary-public_en.pdf. Accessed December 7, 2019."},{"key":"ref40","unstructured":"Eli-Lilly press release. FDA approves Taltz for treatment of ankylosing spondylitis. Available from: https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lilly-receives-us-fda-approval-taltzr-ixekizumab-treatment. August 26, 2019. Accessed December 7, 2019."},{"key":"ref41","unstructured":"Taltz (Ixekizumab), packager insert. Mechanism of Action, Pharmacodynamics and Pharmacokinetics of IXE. IN, USA: Eli Lilly and Company; 2018."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1016\/S0140-6736(18)31946-9","volume":"392","author":"Van der heijde","year":"2018","journal-title":"Lancet"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3899\/jrheum.140519","volume":"42","author":"Maksymowych","year":"2015","journal-title":"J Rheumatol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20575","volume":"63","author":"Zochling","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/art.40753","volume":"71","author":"Deodhar","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/annrheumdis-2019-216118","volume":"79","author":"Dougados","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(19)32971-X","volume":"395","author":"Deodhar","year":"2020","journal-title":"Lancet"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s12026-012-8276-8","volume":"52","author":"Krstic","year":"2012","journal-title":"Immunol Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/art.40551","volume":"70","author":"Varkas","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/acr.v71.10","volume":"71","author":"Ward","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.semarthrit.2015.10.001","volume":"45","author":"Cantini","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1080\/14740338.2016.1221923","volume":"15","author":"Blauvelt","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1002\/acr.23534","volume":"70","author":"Mease","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13075-016-1093-z","volume":"18","author":"de Winter","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/annrheumdis-2016-209709","volume":"76","author":"Mease","year":"2017","journal-title":"Ann Rheum Dis"}],"container-title":["Therapeutics and Clinical Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57422","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:59:43Z","timestamp":1666353583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/therapeutic-potential-of-ixekizumab-in-the-treatment-of-ankylosing-spo-peer-reviewed-article-TCRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":55,"URL":"https:\/\/doi.org\/10.2147\/tcrm.s228880","relation":{},"ISSN":["1178-203X"],"issn-type":[{"type":"electronic","value":"1178-203X"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}