{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:09:55Z","timestamp":1779275395419,"version":"3.51.4"},"reference-count":58,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TCRM"],"DOI":"10.2147\/tcrm.s291798","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T22:07:18Z","timestamp":1622758038000},"page":"589-599","source":"Crossref","is-referenced-by-count":18,"title":["Gene Therapy for Overactive Bladder: A Review of BK-Channel \u03b1-Subunit Gene Transfer"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Karl-Erik","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Joseph","family":"Christ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin P","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S","family":"Rovner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Melman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/nau.20737","volume":"28","author":"Abrams","year":"2009","journal-title":"Neurourol Urodyn"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1046\/j.1464-410X.90.s3.3.x","volume":"90","author":"Van Kerrebroeck","year":"2002","journal-title":"BJU Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11884-016-0344-9","volume":"11","author":"Reynolds","year":"2016","journal-title":"Curr Bladder Dysfunct Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00345-002-0301-4","volume":"20","author":"Stewart","year":"2003","journal-title":"World J Urol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1464-410X.2010.09993.x","volume":"108","author":"Irwin","year":"2011","journal-title":"BJU Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.juro.2012.09.079","volume":"188","author":"Gormley","year":"2012","journal-title":"J Urol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1097\/ju.0000000000000309","volume":"202","author":"Lightner","year":"2019","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.eururo.2013.11.010","volume":"65","author":"Maman","year":"2014","journal-title":"Eur Urol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pharmthera.2018.04.010","volume":"189","author":"Yamada","year":"2018","journal-title":"Pharmacol Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e021889","DOI":"10.1136\/bmjopen-2018-021889","volume":"8","author":"Yeowell","year":"2018","journal-title":"BMJ Open"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1001\/jamainternmed.2019.0677","volume":"179","author":"Coupland","year":"2019","journal-title":"JAMA Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12020128","volume":"12","author":"Lo","year":"2020","journal-title":"Toxins"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"R571","DOI":"10.1152\/ajpregu.00142.2014","volume":"307","author":"Petkov","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/j.1742-1241.2011.02763.x","volume":"65","author":"Lukacz","year":"2011","journal-title":"Int J Clin Pract"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"C1366","DOI":"10.1152\/ajpcell.00027.2006","volume":"291","author":"Wang","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/nau.20784","volume":"29","author":"Andersson","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1152\/physrev.00038.2003","volume":"84","author":"Andersson","year":"2004","journal-title":"Physiol Rev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.3389\/fphys.2018.01937","volume":"9","author":"Chakrabarty","year":"2019","journal-title":"Front Physiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev-med-012017-043332","volume":"70","author":"Anguela","year":"2019","journal-title":"Annu Rev Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1038\/sj.bjp.0706627","volume":"147","author":"Christ","year":"2006","journal-title":"Br J Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11934-010-0145-1","volume":"11","author":"Melman","year":"2010","journal-title":"Curr Urol Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/nau.24272","volume":"39","author":"Rovner","year":"2020","journal-title":"Neurourol Urodyn"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/S0022-5347(17)36455-8","volume":"149","author":"Campos de Carvalho","year":"1993","journal-title":"J Urol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1016\/S0021-9258(17)41720-0","volume":"269","author":"Knaus","year":"1994","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1152\/physrev.00001.2016","volume":"97","author":"Latorre","year":"2017","journal-title":"Physiol Rev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/0896-6273(94)90418-9","volume":"13","author":"Tseng-Crank","year":"1994","journal-title":"Neuron"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1469-7793.2001.00443.x","volume":"537","author":"Petkov","year":"2001","journal-title":"J Physiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1469-7793.2001.t01-3-00313.x","volume":"534","author":"Ohi","year":"2001","journal-title":"J Physiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF01870671","volume":"71","author":"Latorre","year":"1983","journal-title":"J Membr Biol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"36746","DOI":"10.1074\/jbc.M405621200","volume":"279","author":"Meredith","year":"2004","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1442-2042.1997.tb00315.x","volume":"4","author":"Mimata","year":"1997","journal-title":"Int J Urol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1464-410X.2005.05703.x","volume":"96","author":"Neuhaus","year":"2005","journal-title":"BJU International"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1085\/jgp.201912457","volume":"151","author":"Bailey","year":"2019","journal-title":"J Gen Physiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.eururo.2006.11.028","author":"Davies","year":"2007","journal-title":"Eur Urol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e68052","DOI":"10.1371\/journal.pone.0068052","author":"Hristov","year":"2013","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrurol.2016.95","volume":"13","author":"Reynolds","year":"2016","journal-title":"Nat Rev Urol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.3892\/etm.2016.3246","volume":"11","author":"Zhou","year":"2016","journal-title":"Exp Ther Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e104216","DOI":"10.1371\/journal.pone.0104216","volume":"9","author":"Okinami","year":"2014","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1152\/ajprenal.90207.2008","volume":"297","author":"Imamura","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref40","first-page":"e14614","volume":"8","author":"Wang","year":"2020","journal-title":"Physiol Rep"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1080\/17425247.2016.1188802","volume":"13","author":"Jayant","year":"2016","journal-title":"Expert Opin Drug Deliv"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"30675","DOI":"10.18632\/oncotarget.5169","volume":"6","author":"Chira","year":"2015","journal-title":"Oncotarget"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/genes8020065","volume":"8","author":"Hardee","year":"2017","journal-title":"Genes"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.hoc.2017.06.007","volume":"31","author":"Athanasopoulos","year":"2017","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ymthe.2004.05.004","volume":"10","author":"Hagstrom","year":"2004","journal-title":"Mol Ther"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.xphs.2017.09.021","volume":"107","author":"Yamada","year":"2018","journal-title":"J Pharm Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/hum.2006.17.1165","volume":"17","author":"Melman","year":"2006","journal-title":"Hum Gene Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.eururo.2005.05.005","volume":"48","author":"Melman","year":"2005","journal-title":"Eur Urol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.eururo.2008.12.016","volume":"56","author":"Christ","year":"2009","journal-title":"Eur Urol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/sj.gt.3303093","volume":"15","author":"Melman","year":"2008","journal-title":"Gene Ther"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/01.ju.0000063375.12512.6e","volume":"170","author":"Melman","year":"2003","journal-title":"J Urol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"H1544","DOI":"10.1152\/ajpheart.00792.2003","volume":"287","author":"Christ","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref53","first-page":"H600","volume":"275","author":"Christ","year":"1998","journal-title":"Am J Physiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1706","DOI":"10.1016\/S1569-9056(18)32034-7","volume":"12","author":"Arun","year":"2018","journal-title":"Eur Urol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"R1699","DOI":"10.1152\/ajpregu.2001.281.5.R1699","volume":"281","author":"Christ","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/bju.13163","volume":"117","author":"Papagiannopoulou","year":"2016","journal-title":"BJU Int"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0006-8993(93)90926-E","volume":"613","author":"Kruse","year":"1993","journal-title":"Brain Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e201912526","DOI":"10.1085\/jgp.201912526","volume":"152","author":"Wang","year":"2020","journal-title":"J Gen Physiol"}],"container-title":["Therapeutics and Clinical Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70235","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T22:07:38Z","timestamp":1622758058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/gene-therapy-for-overactive-bladder-a-review-of-bk-channel--subunit-ge-peer-reviewed-fulltext-article-TCRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":58,"URL":"https:\/\/doi.org\/10.2147\/tcrm.s291798","relation":{},"ISSN":["1178-203X"],"issn-type":[{"value":"1178-203X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}