{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:07:34Z","timestamp":1781114854681,"version":"3.54.1"},"reference-count":77,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VHRM"],"DOI":"10.2147\/vhrm.s287082","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T02:31:07Z","timestamp":1621823467000},"page":"247-254","source":"Crossref","is-referenced-by-count":38,"title":["Epigenetic Therapies for Heart Failure: Current Insights and Future Potential"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Claudio","family":"Napoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bontempo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-3760","authenticated-orcid":true,"given":"Enrico","family":"Coscioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Maiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-0373","authenticated-orcid":true,"given":"Francesco","family":"Donatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuditta","family":"Benincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.2459\/JCM.0000000000000834","volume":"20","author":"Gronda","year":"2019","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10741-019-09823-z","volume":"25","author":"Gronda","year":"2020","journal-title":"Heart Fail Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2147\/VHRM.S197291","volume":"16","author":"Sokos","year":"2020","journal-title":"Vasc Health Risk Manag"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/ehf2.12610","volume":"7","author":"Cacciatore","year":"2020","journal-title":"ESC Heart Fail"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1001\/jama.2020.15566","volume":"324","author":"Clark","year":"2020","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"107514","DOI":"10.1016\/j.pharmthera.2020.107514","volume":"210","author":"Schiano","year":"2020","journal-title":"Pharmacol Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0236951","DOI":"10.1371\/journal.pone.0236951","volume":"15","author":"Schiano","year":"2020","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001867","author":"Benincasa","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.amsu.2020.10.016","volume":"60","author":"Benincasa","year":"2020","journal-title":"Ann Med Surg (Lond)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/ehjcvp\/pvz062","volume":"6","author":"Napoli","year":"2020","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/HCO.0000000000000843","volume":"36","author":"Napoli","year":"2021","journal-title":"Curr Opin Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e0210909","DOI":"10.1371\/journal.pone.0210909","volume":"14","author":"Infante","year":"2019","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1001\/jamacardio.2018.3546","volume":"3","author":"de Nigris","year":"2018","journal-title":"JAMA Cardiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ahj.2020.03.007","volume":"224","author":"Napoli","year":"2020","journal-title":"Am Heart J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13148-021-01047-z","volume":"13","author":"Sarno","year":"2021","journal-title":"Clin Epigenetics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s11883-014-0476-3","volume":"17","author":"Grimaldi","year":"2014","journal-title":"Curr Atheroscler Rep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.trre.2017.08.004","volume":"31","author":"Sabia","year":"2017","journal-title":"Transplant Rev (Orlando)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"100609","DOI":"10.1016\/j.trre.2021.100609","volume":"35","author":"Vasco","year":"2021","journal-title":"Transplant Rev (Orlando)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(08)61239-8","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1001\/jama.2020.3308","volume":"323","author":"Ray","year":"2020","journal-title":"JAMA"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jacc.2020.01.018","volume":"75","author":"Marfella","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12933-020-01199-x","volume":"20","author":"Nicholls","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.1038\/emboj.2012.233","volume":"31","author":"Gaucher","year":"2012","journal-title":"EMBO J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1161\/CIRCRESAHA.120.315929","volume":"126","author":"Borck","year":"2020","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3390\/ijms21041297","volume":"21","author":"Tonini","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature09589","volume":"468","author":"Nicodeme","year":"2010","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e100293","DOI":"10.15252\/embj.2018100293","volume":"38","author":"Dey","year":"2019","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"19754","DOI":"10.1073\/pnas.1310658110","volume":"110","author":"Picaud","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e83190","DOI":"10.1371\/journal.pone.0083190","volume":"8","author":"McLure","year":"2013","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.jacc.2010.02.035","volume":"55","author":"Bailey","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cell.2013.07.013","volume":"154","author":"Anand","year":"2013","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.yjmcc.2018.12.002","volume":"127","author":"Song","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/15592294.2015.1024406","volume":"10","author":"Ooi","year":"2015","journal-title":"Epigenetics"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.yjmcc.2015.03.010","volume":"83","author":"Ferguson","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12933-015-0262-8","volume":"14","author":"Chen","year":"2015","journal-title":"Cardiovasc Diabetol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/s0092-8674(02)00861-9","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.yjmcc.2013.07.017","volume":"63","author":"Spiltoir","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"107424842097923","DOI":"10.1177\/1074248420979235","author":"Russell-Hallinan","year":"2020","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/labinvest.2011.92","volume":"91","author":"Kao","year":"2011","journal-title":"Lab Invest"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/dom.13262","volume":"20","author":"Bridgeman","year":"2018","journal-title":"Diabetes Obes Metab"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/cvr\/cvq066","volume":"87","author":"Xiao","year":"2010","journal-title":"Cardiovasc Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"103270","DOI":"10.1016\/j.retram.2020.103270","volume":"69","author":"Zhao","year":"2021","journal-title":"Curr Res Transl Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1111\/bph.13166","volume":"172","author":"Sun","year":"2015","journal-title":"Br J Pharmacol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e018889","DOI":"10.1161\/JAHA.120.018889","volume":"9","author":"Gronda","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12933-019-0849-6","volume":"18","author":"Lee","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12933-019-0816-2","volume":"18","author":"Li","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12933-019-0980-4","volume":"19","author":"Arow","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.redox.2017.06.009","volume":"13","author":"Steven","year":"2017","journal-title":"Redox Biol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1056\/NEJMc1600827","volume":"374","author":"Zinman","year":"2016","journal-title":"N Engl J Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e004262","DOI":"10.1161\/JAHA.116.004262","volume":"6","author":"Zamani","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12933-020-01100-w","volume":"19","author":"Halabi","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ijcard.2019.11.087","volume":"306","author":"Gu","year":"2020","journal-title":"Int J Cardiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1253\/circj.CJ-18-0639","volume":"83","author":"Marume","year":"2019","journal-title":"Circ J"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.amjcard.2018.04.027","volume":"122","author":"Lee","year":"2018","journal-title":"Am J Cardiol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e013389","DOI":"10.1161\/JAHA.119.013389","volume":"8","author":"Lam","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0140-6736(20)31824-9","volume":"396","author":"Zannad","year":"2020","journal-title":"Lancet"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"8805","DOI":"10.1038\/s41598-018-27181-y","volume":"8","author":"Nishitani","year":"2018","journal-title":"Sci Rep"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1755-5922.2008.00053.x","volume":"26","author":"Wong","year":"2008","journal-title":"Cardiovasc Ther"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00592-008-0090-3","volume":"46","author":"Pantalone","year":"2009","journal-title":"Acta Diabetol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1517\/14656566.2012.638283","volume":"13","author":"Papanas","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1056\/NEJMoa0706201","volume":"357","author":"Kjekshus","year":"2007","journal-title":"N Engl J Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0140-6736(08)61240-4","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/CIRCHEARTFAILURE.114.001730","volume":"8","author":"Alehagen","year":"2015","journal-title":"Circ Heart Fail"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","volume":"75","author":"Calder","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"ref66","first-page":"6","volume":"13","author":"Mohebi-Nejad","year":"2014","journal-title":"Tanaffos"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/MCO.0000000000000023","volume":"17","author":"Burdge","year":"2014","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"25867","DOI":"10.1038\/srep25867","volume":"6","author":"de la Rocha","year":"2016","journal-title":"Sci Rep"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1161\/CIRCULATIONAHA.115.019949","volume":"134","author":"Heydari","year":"2016","journal-title":"Circulation"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.jchf.2019.03.008","volume":"7","author":"Block","year":"2019","journal-title":"JACC Heart Fail"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.1016\/j.dsx.2016.03.016","volume":"10","author":"Berezin","year":"2016","journal-title":"Diabetes Metab Syndr"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jdiacomp.2018.08.012","volume":"32","author":"Sommese","year":"2018","journal-title":"J Diabetes Complications"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"165729","DOI":"10.1016\/j.bbadis.2020.165729","volume":"1866","author":"Trum","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10079-9","author":"Nikolic","year":"2021","journal-title":"Heart Fail Rev"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"e13388","DOI":"10.1111\/eci.13388.","volume":"50","author":"Mohammadzadeh","year":"2020","journal-title":"Eur J Clin Invest"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Benincasa G, DeMeo DL, Glass K, Silverman EK, Napoli C. Epigenetics and pulmonary diseases in the horizon of precision medicine: a review. Eur Respir J. 2020 Nov 19:2003406. doi:10.1183\/13993003.03406-2020.77.","DOI":"10.1183\/13993003.03406-2020"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Benincasa G, Marfella R, Della Mura N, et al. Strengths and opportunities of network medicine in cardiovascular diseases. Circ J. 2020 Jan 24;84(2):144\u2013152. doi:10.1253\/circj.CJ-19-0879.","DOI":"10.1253\/circj.CJ-19-0879"}],"container-title":["Vascular Health and Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=69693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=69693","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T02:31:14Z","timestamp":1621823474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/epigenetic-therapies-for-heart-failure-current-insights-and-future-pot-peer-reviewed-fulltext-article-VHRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":77,"URL":"https:\/\/doi.org\/10.2147\/vhrm.s287082","relation":{},"ISSN":["1178-2048"],"issn-type":[{"value":"1178-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}