{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:41:19Z","timestamp":1787024479329,"version":"build-2736575974"},"reference-count":39,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VHRM"],"DOI":"10.2147\/vhrm.s383007","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T12:35:07Z","timestamp":1671021307000},"page":"867-878","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Sequential Nephron Blockade versus Dual Renin-Angiotensin System Blockade Plus Bisoprolol in the Treatment of Resistant Hypertension, a Randomized Controlled Trial (Resistant Hypertension on Treatment - ResHypOT)"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-0305","authenticated-orcid":true,"given":"Elizabeth do Espirito Santo","family":"Cestario","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-2825","authenticated-orcid":true,"given":"Jose Fernando","family":"Vilela-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1325-1082","authenticated-orcid":true,"given":"Luciana Neves","family":"Cosenso-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Azevedo","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Rodrigues Roma","family":"Uyemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valquiria","family":"da Silva Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Aparecida Barufi","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Helena","family":"Bonalume Tacito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-697X","authenticated-orcid":true,"given":"Heitor","family":"Moreno Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-6536","authenticated-orcid":true,"given":"Juan Carlos","family":"Yugar-Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1001\/jama.1996.03530440051036","volume":"275","author":"Kannel","year":"1996","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3S","DOI":"10.1016\/S0895-7061(99)00252-6","volume":"13","author":"Kannel","year":"2000","journal-title":"Am J Hypertens"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1161\/HYPERTENSIONAHA.116.08249","volume":"69","author":"Karmali","year":"2017","journal-title":"Hypertension"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1161\/HYPERTENSIONAHA.108.189141","volume":"51","author":"Calhoun","year":"2008","journal-title":"Hypertension"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1161\/hyp.0000000000000084","volume":"72","author":"Carey Robert","year":"2018","journal-title":"Hypertension"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11906-018-0825-7","volume":"20","author":"Yugar-Toledo","year":"2018","journal-title":"Curr Hypertens Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/ajh\/hpu151","volume":"28","author":"Achelrod","year":"2015","journal-title":"Am J Hypertens"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1161\/HYPERTENSIONAHA.117.10662","volume":"71","author":"Krieger","year":"2018","journal-title":"Hypertension"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1161\/CIRCULATIONAHA.111.068064","volume":"125","author":"Daugherty","year":"2012","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/01.hyp.0000016176.16042.2f","volume":"39","author":"Taler","year":"2002","journal-title":"Hypertension"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/HYPERTENSIONAHA.109.131235","volume":"54","author":"Pimenta","year":"2009","journal-title":"Hypertension"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1093\/ndt\/gfs384","volume":"27","author":"Agarwal","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/hr.2013.69","volume":"36","author":"Shimosawa","year":"2013","journal-title":"Hypertens Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tcm.2016.05.004","volume":"26","author":"Eirin","year":"2016","journal-title":"Trends Cardiovasc Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/jhh.2014.64","volume":"29","author":"Liu","year":"2015","journal-title":"J Hum Hypertens"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.mayocp.2013.06.017","volume":"88","author":"Sim","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"642416","DOI":"10.4061\/2011\/642416","volume":"2011","author":"Tsioufis","year":"2011","journal-title":"Int J Hypertens"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1097\/HJH.0b013e3283551e98","volume":"30","author":"Bobrie","year":"2012","journal-title":"J Hypertens"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13063-017-2343-3","volume":"19","author":"Cestario","year":"2018","journal-title":"Trials"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1590\/s0066-782x2012000700002","volume":"99","author":"Alessi","year":"2012","journal-title":"Arq Bras Cardiol"},{"key":"ref21","first-page":"1","volume":"95","author":"Brand\u00e3o","year":"2010","journal-title":"Arq Bras Cardiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S0066-782X2011000900001","volume":"97","author":"Dohmann","year":"2011","journal-title":"Arq Bras Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1751-7176.2009.00102.x","volume":"11","author":"de Souza","year":"2009","journal-title":"J Clin Hypertens"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1097\/HJH.0b013e32833d4c99","volume":"28","author":"Alvarez-Alvarez","year":"2010","journal-title":"J Hypertens"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra0907219","volume":"361","author":"Ernst","year":"2009","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/S0140-6736(15)00257-3","volume":"386","author":"Williams","year":"2015","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S2213-8587(18)30071-8","volume":"6","author":"Williams","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2147\/VHRM.S138599","volume":"13","author":"Yugar-Toledo","year":"2017","journal-title":"Vasc Health Risk Manag"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1161\/HYPERTENSIONAHA.109.140988","volume":"55","author":"de Souza","year":"2010","journal-title":"Hypertension"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/ajh\/hpw105","volume":"30","author":"Dudenbostel","year":"2017","journal-title":"Am J Hypertens"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"F133","DOI":"10.1152\/ajprenal.00227.2002","volume":"284","author":"Na","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1136\/bmj.321.7274.1440","volume":"321","author":"Mogensen","year":"2000","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/sj.ki.5002455","volume":"72","author":"Bakris","year":"2007","journal-title":"Kidney Int"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1053\/j.ajkd.2012.07.011","volume":"61","author":"Fernandez Juarez","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1681\/ASN.2009070737","volume":"20","author":"Mehdi","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","volume":"358","author":"Investigators","year":"2008","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00108-009-2391-1","volume":"50","author":"Schmieder","year":"2009","journal-title":"Internist"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1177\/1470320311434818","volume":"13","author":"Parving","year":"2012","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1161\/01.HYP.0000161880.59963.da","volume":"45","author":"Doulton","year":"2005","journal-title":"Hypertension"}],"container-title":["Vascular Health and Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86159","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T12:35:10Z","timestamp":1671021310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/effect-of-sequential-nephron-blockade-versus-dual-renin-angiotensin-sy-peer-reviewed-fulltext-article-VHRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":39,"URL":"https:\/\/doi.org\/10.2147\/vhrm.s383007","relation":{},"ISSN":["1178-2048"],"issn-type":[{"value":"1178-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}