{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:28:05Z","timestamp":1790638085411,"version":"4.1.0"},"reference-count":63,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VHRM"],"DOI":"10.2147\/vhrm.s383572","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T03:51:34Z","timestamp":1666237894000},"page":"823-832","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating Riociguat in the Treatment of Pulmonary Arterial Hypertension: A Real-World Perspective"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Andrew D","family":"Mihalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sula","family":"Mazimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMra2000348","volume":"385","author":"Hassoun","year":"2021","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1183\/13993003.01914-2018","volume":"53","author":"Nathan","year":"2019","journal-title":"Eur Respir J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1183\/13993003.01897-2018","volume":"53","author":"Vachiery","year":"2019","journal-title":"Eur Respir J"},{"key":"ref5","first-page":"326","volume":"53","author":"Kim","year":"2019","journal-title":"Eur Respir J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1164\/ajrccm.158.4.9802113","volume":"158","author":"Archer","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJM199507273330403","volume":"333","author":"Giaid","year":"1995","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1164\/rccm.200403-340OC","volume":"171","author":"Migneault","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","volume":"15","author":"Farah","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"18709","DOI":"10.1074\/jbc.273.30.18709","volume":"273","author":"Liu","year":"1998","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1056\/NEJMoa035477","volume":"350","author":"Gladwin","year":"2004","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1056\/NEJMoa1209657","volume":"369","author":"Ghofrani","year":"2013","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1056\/NEJMoa1209655","volume":"369","author":"Ghofrani","year":"2013","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1183\/09031936.00105914","volume":"45","author":"Galie","year":"2015","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2045894019848644","DOI":"10.1177\/2045894019848644","volume":"9","author":"DeJesus","year":"2019","journal-title":"Pulm Circ"},{"key":"ref16","first-page":"S49","volume":"6","author":"Becker","year":"2016","journal-title":"Pulm Circ"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/17425255.2019.1681968","volume":"15","author":"Jungmann","year":"2019","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s40262-015-0337-4","volume":"55","author":"Zhao","year":"2016","journal-title":"Clin Pharmacokinet"},{"key":"ref19","first-page":"163","volume":"10","author":"Dowdall","year":"2014","journal-title":"Future Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1183\/09031936.00090614","volume":"45","author":"Rubin","year":"2015","journal-title":"Eur Respir J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/annrheumdis-2015-209087","volume":"76","author":"Humbert","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2045894018769305","DOI":"10.1177\/2045894018769305","volume":"8","author":"Cartin-Ceba","year":"2018","journal-title":"Pulm Circ"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chest.2017.12.008","volume":"154","author":"Khouri","year":"2018","journal-title":"Chest"},{"key":"ref24","first-page":"215","volume":"50","author":"Hoeper","year":"2017","journal-title":"Eur Respir J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2003.12.023","volume":"99","author":"Chockalingam","year":"2005","journal-title":"Int J Cardiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.rmed.2016.11.001","volume":"122","author":"Hoeper","year":"2017","journal-title":"Respir Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S2213-2600(20)30567-1","volume":"9","author":"Frantz","year":"2021","journal-title":"Lancet Respir Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2213-2600(20)30532-4","volume":"9","author":"Hoeper","year":"2021","journal-title":"Lancet Respir Med"},{"key":"ref29","first-page":"39","volume":"22","author":"Andersen","year":"2017","journal-title":"Respir Med Case Rep"},{"key":"ref30","first-page":"2045894019837849","volume":"1","author":"Benza","year":"2019","journal-title":"Pulm Circ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00408-018-0100-3","volume":"196","author":"Gall","year":"2018","journal-title":"Lung"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12890-016-0229-x","volume":"16","author":"Poch","year":"2016","journal-title":"BMC Pulm Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/2045893217721694","volume":"7","author":"Raina","year":"2017","journal-title":"Pulm Circ"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/2045893217708566","volume":"7","author":"Davey","year":"2017","journal-title":"Pulm Circ"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.hlc.2019.01.013","volume":"29","author":"Kuroda","year":"2020","journal-title":"Heart Lung Circ"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijcard.2021.03.034","volume":"332","author":"Benza","year":"2021","journal-title":"Int J Cardiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e12055","DOI":"10.1002\/pul2.12055","volume":"12","author":"Rahaghi","year":"2022","journal-title":"Pulm Circ"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2045893217743123","DOI":"10.1177\/2045893217743123","volume":"8","author":"Spreemann","year":"2018","journal-title":"Pulm Circ"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s40256-018-0272-5","volume":"18","author":"Burks","year":"2018","journal-title":"Am J Cardiovasc Drugs"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.202107-1625ED","volume":"204","author":"Cascino","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jacc.2021.07.057","volume":"78","author":"Chin","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1753466621995048","DOI":"10.1177\/1753466621995048","volume":"15","author":"Momoi","year":"2021","journal-title":"Ther Adv Respir Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2045894019826944","DOI":"10.1177\/2045894019826944","volume":"9","author":"Sulica","year":"2019","journal-title":"Pulm Circ"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1253\/circrep.CR-20-0133","volume":"3","author":"Akagi","year":"2021","journal-title":"Circ Rep"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCULATIONAHA.113.001458","volume":"128","author":"Bonderman","year":"2013","journal-title":"Circulation"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s00508-016-1068-8","volume":"128","author":"Mascherbauer","year":"2016","journal-title":"Wien Klin Wochenschr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1915928","volume":"382","author":"Armstrong","year":"2020","journal-title":"N Engl J Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S2213-2600(19)30250-4","volume":"7","author":"Nathan","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.healun.2021.02.006","volume":"40","author":"Nathan","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/S2213-2600(19)30378-9","volume":"7","author":"Harari","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1183\/13993003.01792-2016","volume":"49","author":"Ende-Verhaar","year":"2017","journal-title":"Eur Respir J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1513\/AnnalsATS.201509-621AS","volume":"13","author":"Delcroix","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1183\/09031936.00175907","volume":"32","author":"Bourbonnais","year":"2008","journal-title":"Eur Respir J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/13993003.00897-2019","volume":"54","author":"Huitema","year":"2019","journal-title":"Eur Respir J"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.chest.2021.07.2162","volume":"161","author":"Baughman","year":"2022","journal-title":"Chest"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1056\/NEJMra043184","volume":"352","author":"Rowe","year":"2005","journal-title":"N Engl J Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1164\/rccm.200703-344OC","volume":"177","author":"Lubamba","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jcf.2021.07.015","volume":"20","author":"Derichs","year":"2021","journal-title":"J Cyst Fibros"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N Engl J Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/annrheumdis-2011-200862","volume":"71","author":"Beyer","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/annrheumdis-2019-216823","volume":"79","author":"Khanna","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1056\/NEJMoa1503184","volume":"373","author":"Sitbon","year":"2015","journal-title":"N Engl J Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1378\/chest.13-1759","volume":"145","author":"Rogers","year":"2014","journal-title":"Chest"}],"container-title":["Vascular Health and Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84846","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T03:52:37Z","timestamp":1666237957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/evaluating-riociguat-in-the-treatment-of-pulmonary-arterial-hypertensi-peer-reviewed-fulltext-article-VHRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":63,"URL":"https:\/\/doi.org\/10.2147\/vhrm.s383572","relation":{},"ISSN":["1178-2048"],"issn-type":[{"value":"1178-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}