{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:37:51Z","timestamp":1778881071676,"version":"3.51.4"},"reference-count":54,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VHRM"],"DOI":"10.2147\/vhrm.s394134","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T15:45:06Z","timestamp":1674056706000},"page":"31-41","source":"Crossref","is-referenced-by-count":13,"title":["Elevated Lp(a) Levels Correlate with Severe and Multiple Coronary Artery Stenotic Lesions"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8386-4063","authenticated-orcid":true,"given":"Cynthia","family":"Al Hageh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-4749","authenticated-orcid":true,"given":"Stephanie","family":"Chacar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michella","family":"Ghassibe-Sabbagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E","family":"Platt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Henschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdan","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Gauguier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"El Murr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-9166","authenticated-orcid":true,"given":"Eman","family":"Alefishat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Chammas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobh\u00e1n","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Abchee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-5213","authenticated-orcid":true,"given":"Moni","family":"Nader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre A","family":"Zalloua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.atherosclerosis.2012.02.035","volume":"222","author":"Ghassibe-Sabbagh","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/MAJ.0b013e31818af6de","volume":"337","author":"Keshet","year":"2009","journal-title":"Am J Med Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1056\/NEJMoa043175","volume":"353","author":"Tsimikas","year":"2005","journal-title":"N Eng J Med"},{"key":"ref6","volume-title":"Lipoprotein(a), in the Online Metabolic and Molecular Bases of Inherited Disease","year":"2019"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1161\/ATV.0000000000000147","volume":"42","author":"Reyes-Soffer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cjca.2016.07.510","volume":"32","author":"Anderson","year":"2016","journal-title":"Can J Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1109034","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref11","volume-title":"Lp(a) with CRP Levels Predict Death, MI Risk in Korean Cohort with Documented CAD","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0021-9150(86)90099-7","volume":"62","author":"Armstrong","year":"1986","journal-title":"Atherosclerosis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1161\/01.CIR.74.4.758","volume":"74","author":"Dahlen","year":"1986","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1373\/clinchem.2003.023689","volume":"49","author":"Marcovina","year":"2003","journal-title":"Clin Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0014-5793(83)80182-3","volume":"154","author":"Utermann","year":"1983","journal-title":"FEBS Lett"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/S0022-2275(20)34257-7","volume":"26","author":"Armstrong","year":"1985","journal-title":"J Lipid Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4582","DOI":"10.1016\/S0021-9258(18)32663-2","volume":"258","author":"Gaubatz","year":"1983","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ihj.2019.03.004","volume":"71","author":"Enas","year":"2019","journal-title":"Indian Heart J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/ATVBAHA.114.304785","volume":"35","author":"Guan","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","volume":"37","author":"Catapano","year":"2016","journal-title":"Eur Heart J"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1093\/eurheartj\/ehq386","volume":"31","author":"Nordestgaard","year":"2010","journal-title":"Eur Heart J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1161\/ATVBAHA.116.308011","volume":"36","author":"Varvel","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1194\/jlr.R051904","volume":"57","author":"Enkhmaa","year":"2016","journal-title":"J Lipid Res"},{"key":"ref24","volume-title":"Introduction to Lipids and Lipoproteins","year":"2000"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1001\/jama.2009.1619","volume":"302","author":"Di Angelantonio","year":"2009","journal-title":"JAMA"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829\u20131839. doi:https:\/\/doi.org\/10.1016\/S0140-6736(07)61778-4","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/STROKEAHA.121.034924","volume":"2022","author":"Xu","year":"2022","journal-title":"Stroke"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12872-022-02618-5","volume":"22","author":"Zhu","year":"2022","journal-title":"BMC Cardiovasc Disord"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s12265-021-10148-2","volume":"15","author":"Ren","year":"2022","journal-title":"J Cardiovasc Transl Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12872-021-01861-6","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/MAJ.0b013e31815d4419","volume":"336","author":"Venkatesh","year":"2008","journal-title":"Am J Med Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.amjcard.2006.06.059","volume":"98","author":"Forrester","year":"2006","journal-title":"Am J Cardiol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s11883-010-0091-x","volume":"12","author":"Ragbir","year":"2010","journal-title":"Curr Atheroscler Rep"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nrcardio.2015.124","volume":"13","author":"Rosenson","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.jacl.2019.04.010","volume":"13","author":"Wilson","year":"2019","journal-title":"J Clin Lipidol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e010932","DOI":"10.1161\/JAHA.118.010932","volume":"8","author":"Shapiro","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1161\/CIRCULATIONAHA.118.037184","volume":"139","author":"O\u2019Donoghue","year":"2019","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s40265-019-01243-5","volume":"80","author":"Gencer","year":"2020","journal-title":"Drugs"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.jacc.2016.05.089","volume":"68","author":"Lee","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11239-014-1069-2","volume":"39","author":"Platt","year":"2015","journal-title":"J Thromb Thrombolysis"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.amjcard.2005.05.018","volume":"96","author":"Makaryus","year":"2005","journal-title":"Am J Cardiol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1161\/01.CIR.86.1.232","volume":"86","author":"Dodge","year":"1992","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1159\/000481765","volume":"43","author":"Zhou","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1148\/108.3.567","volume":"108","author":"MacAlpin","year":"1973","journal-title":"Radiology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/clc.4960270503","volume":"27","author":"Deb","year":"2004","journal-title":"Clin Cardiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1161\/01.ATV.17.5.905","volume":"17","author":"Nielsen","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref47","first-page":"1","volume":"2016","author":"Kostner","year":"2016","journal-title":"J Lipid Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/370460a0","volume":"370","author":"Grainger","year":"1994","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1126\/science.8503012","volume":"260","author":"Grainger","year":"1993","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","volume":"361","author":"Clarke","year":"2009","journal-title":"N Engl J Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09270","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.atherosclerosissup.2015.02.039","volume":"18","author":"Kassner","year":"2015","journal-title":"Atheroscler Suppl"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.jacc.2021.12.032","volume":"79","author":"Yeang","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"ref54","unstructured":"Novartis P. A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of Lipoprotein(a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease; 2022. Available from: clinicaltrials.gov. Accessed January 05, 2022."}],"container-title":["Vascular Health and Risk Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86892","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T15:45:15Z","timestamp":1674056715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/elevated-lpa-levels-correlate-with-severe-and-multiple-coronary-artery-peer-reviewed-fulltext-article-VHRM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":54,"URL":"https:\/\/doi.org\/10.2147\/vhrm.s394134","relation":{},"ISSN":["1178-2048"],"issn-type":[{"value":"1178-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}