{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:25:43Z","timestamp":1768440343970,"version":"3.49.0"},"reference-count":66,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s477512","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T11:15:11Z","timestamp":1732619711000},"page":"12695-12718","source":"Crossref","is-referenced-by-count":5,"title":["Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-533X","authenticated-orcid":true,"given":"Vaikunthavasan","family":"Thiruchenthooran","sequence":"first","affiliation":[]},{"given":"Marta","family":"\u015awitalska","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Maciejewska","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Palko-\u0141abuz","sequence":"additional","affiliation":[]},{"given":"Lorena","family":"Bonilla-Vidal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6606","authenticated-orcid":true,"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":true,"given":"Eliana","family":"Souto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-108X","authenticated-orcid":true,"given":"Elena","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-6369","authenticated-orcid":true,"given":"Anna","family":"Gliszczy\u0144ska","sequence":"additional","affiliation":[]}],"member":"301","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5503","DOI":"10.1200\/JCO.2019.37.15_SUPPL.5503","volume":"37","author":"Kenter","year":"2016","journal-title":"Am Soc Clin Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.3390\/CANCERS13081880\/S1","volume":"13","author":"Horeweg","year":"2021","journal-title":"Cancers"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/J.BIOACTMAT.2023.06.016","volume":"29","author":"Xu","year":"2023","journal-title":"Bioact Mater"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1001\/JAMAINTERNMED.2017.3601","volume":"177","author":"Prasad","year":"2017","journal-title":"JAMA Intern Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.semcancer.2019.09.012","volume":"82","author":"Aggarwal","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/J.CANLET.2018.04.039","volume":"428","author":"Basso","year":"2018","journal-title":"Cancer Lett"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.3892\/mmr.2015.3331","volume":"11","author":"Qin","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-14-567","volume":"14","author":"Deb","year":"2014","journal-title":"BMC Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.bbrc.2017.06.148","volume":"490","author":"Wang","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.3892\/OR.2018.6321\/HTML","volume":"39","author":"Sun","year":"2018","journal-title":"Oncol Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.3390\/APP10155076","volume":"Vol 10","author":"Ko","year":"2020","journal-title":"Appl Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0378-5173(91)90363-S","volume":"69","author":"Lin","year":"1991","journal-title":"Int J Pharm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1081\/DDC-100100359","volume":"26","author":"Srinath","year":"2000","journal-title":"Drug Dev Ind Pharm"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/J.JCIS.2017.08.011","volume":"507","author":"Froelich","year":"2017","journal-title":"J Colloid Interface Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/J.EJPB.2016.10.015","volume":"109","author":"Balguri","year":"2016","journal-title":"Eur J Pharm Biopharm"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.2147\/IJN.S46900","volume":"9","author":"Weissig","year":"2014","journal-title":"Int J Nanomed"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S40824-023-00426-2\/FIGURES\/13","volume":"27","author":"Li","year":"2023","journal-title":"Biomater Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1021\/ACSNANO.3C10249\/SUPPL_FILE\/NN3C10249_SI_001.PDF","volume":"18","author":"Ma","year":"2024","journal-title":"ACS Nano"},{"key":"ref20","unstructured":"Market Data Forecast. Global nanomedicine market size, share, trends and growth analysis report - segmented by products, disease type, nanomolecule type and region - industry forecast (2023 to 2028). Availabel from: https:\/\/www.marketdataforecast.com\/market-reports\/nanomedicine-market. Accessed February 22, 2024."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"7033","DOI":"10.2147\/IJN.S464239","volume":"19","author":"Thiruchenthooran","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1080\/03602532.2020.1716784","volume":"52","author":"Liu","year":"2020","journal-title":"Drug Metab Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02593227","volume":"23","author":"Bauer","year":"1946","journal-title":"Oil Soap"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e0172238","DOI":"10.1371\/JOURNAL.PONE.0172238","volume":"12","author":"Gliszczy\u0144ska","year":"2017","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"35744","DOI":"10.1039\/C8RA07002D","volume":"8","author":"Czarnecka","year":"2018","journal-title":"RSC Adv"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.3390\/MOLECULES23082022","volume":"23","author":"Czarnecka","year":"2018","journal-title":"Molecules"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"11310","DOI":"10.3390\/ijms231911310","volume":"23","author":"Thiruchenthooran","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/J.1468-2494.2010.00626.X","volume":"33","author":"Lacerda","year":"2011","journal-title":"Int J Cosmet Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1007\/s12274-020-2940-4","volume":"13","author":"Anaraki","year":"2020","journal-title":"Nano Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.colsurfb.2016.04.054","volume":"145","author":"S\u00e1nchez-L\u00f3pez","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/J.INTIMP.2019.105856","volume":"71","author":"Yang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/ICS.12119","volume":"36","author":"Abla","year":"2014","journal-title":"Int J Cosmet Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"119480","DOI":"10.1016\/J.IJPHARM.2020.119480","volume":"585","author":"Carvajal-Vidal","year":"2020","journal-title":"Int J Pharm"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e106186","DOI":"10.1371\/JOURNAL.PONE.0106186","volume":"9","author":"Nevozhay","year":"2014","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"10938","DOI":"10.1021\/ACS.CHEMREV.5B00046\/ASSET\/ACS.CHEMREV.5B00046.FP.PNG_V03","volume":"115","author":"Pattni","year":"2015","journal-title":"Chem Rev"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/J.JDDST.2017.03.027","volume":"39","author":"Singh","year":"2017","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/J.1527-3458.2007.00014.X","volume":"13","author":"Dvir","year":"2007","journal-title":"CNS Drug Rev"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.JCONREL.2007.10.025","volume":"126","author":"Dahan","year":"2008","journal-title":"J Control Release"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1021\/ACS.MOLPHARMACEUT.6B01027","volume":"14","author":"Irby","year":"2017","journal-title":"Mol Pharm"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"8440","DOI":"10.1073\/PNAS.83.22.8440","volume":"83","author":"Pearson","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"12974","DOI":"10.1021\/JP960669L","volume":"100","author":"Kohn","year":"1996","journal-title":"J Phys Chem"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1021\/JA983494X","volume":"121","author":"Parr","year":"1999","journal-title":"J Am Chem Soc"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/J.MICROC.2019.01.030","volume":"146","author":"Chmiel","year":"2019","journal-title":"Microchem J"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv Drug Deliv Rev"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.3390\/MOLECULES20045360","volume":"20","author":"Da Silva","year":"2015","journal-title":"Moleclus"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3390\/PHARMACEUTICS12111068","volume":"12","author":"Zukancic","year":"2020","journal-title":"Pharm"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3109\/02713681003760168","volume":"35","author":"Souto","year":"2010","journal-title":"Curr Eye Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1515\/JAS-2015-0018","volume":"59","author":"Sve\u010dnjak","year":"2015","journal-title":"J Apic Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"150","DOI":"10.34172\/APB.2020.021","volume":"10","author":"Chauhan","year":"2020","journal-title":"Adv Pharm Bull"},{"key":"ref50","unstructured":"US Food & Drug Administration. Inactive ingredient search for approved drug products. Available from: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/iig\/index.cfm. Accessed December 25, 2023."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ijpharm.2019.03.056","volume":"563","author":"Amasya","year":"2019","journal-title":"Int J Pharm"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/J.AJPS.2020.07.005","volume":"16","author":"Di","year":"2021","journal-title":"Asian J Pharm Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/J.EJPS.2005.08.002","volume":"27","author":"Fang","year":"2006","journal-title":"Eur J Pharm Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/J.YMTHE.2017.12.018","volume":"26","author":"Jasinski","year":"2018","journal-title":"Mol Ther"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2174\/157016311796799062","volume":"8","author":"Muller","year":"2011","journal-title":"Curr Drug Discov Technol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"7436","DOI":"10.3390\/MOLECULES26247436","volume":"26","author":"Jamr\u00f3giewicz","year":"2021","journal-title":"Molecules"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/SCIPHARM89020025","volume":"89","author":"Ajiboye","year":"2021","journal-title":"Sci Pharm 2021"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0378-5173(99)00426-3","volume":"196","author":"Jenning","year":"2000","journal-title":"Int J Pharm"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"8586","DOI":"10.1021\/ACSNANO.3C01094\/SUPPL_FILE\/NN3C01094_SI_001.PDF","volume":"17","author":"Hu","year":"2023","journal-title":"ACS Nano"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"Mitchell","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/J.COLSURFB.2016.02.065","volume":"143","author":"Sun","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"11557","DOI":"10.1021\/JF503489V\/SUPPL_FILE\/JF503489V_SI_001.PDF","volume":"62","author":"Ban","year":"2014","journal-title":"J Agric Food Chem"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"102026","DOI":"10.1016\/J.NANO.2019.102026","volume":"20","author":"Carvajal-Vidal","year":"2019","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/S40005-017-0320-1\/FIGURES\/7","volume":"47","author":"Son","year":"2017","journal-title":"J Pharm Invest"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4103\/1735-5362.235156","volume":"13","author":"Ghasemiyeh","year":"2018","journal-title":"Res Pharm Sci"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jcis.2015.10.057","volume":"463","author":"Neves","year":"2016","journal-title":"J Colloid Interface Sci"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/97739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/97739","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T11:15:14Z","timestamp":1732619714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multifunctional-indomethacin-conjugates-for-the-development-of-nanosys-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":66,"URL":"https:\/\/doi.org\/10.2147\/ijn.s477512","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}