{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:40:30Z","timestamp":1783431630627,"version":"3.54.6"},"reference-count":49,"publisher":"University of Tokushima Faculty of Medicine","issue":"1,2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2010]]},"DOI":"10.2152\/jmi.57.95","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T06:02:27Z","timestamp":1268978547000},"page":"95-108","source":"Crossref","is-referenced-by-count":18,"title":["Fibroblast growth factor 23 mediates the phosphaturic actions of cadmium"],"prefix":"10.2152","volume":"57","author":[{"given":"Fumito","family":"Aranami","sequence":"first","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Segawa","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Furutani","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuyo","family":"Hanabusa","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Kido","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Ito","sequence":"additional","affiliation":[{"name":"School of Human Science and Environment, University of Hyogo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Deprtment of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36479"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kurosu H, Kuro-o M: The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 299: 72-78, 2009","DOI":"10.1016\/j.mce.2008.10.052"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Razzaque MS: FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player? Am J Physiol Renal Physiol 296: F470-476, 2009","DOI":"10.1152\/ajprenal.90538.2008"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/81664"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101545198"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041799"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500457200"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kuro-o M: Overview of the FGF23-Klotho axis. Pediatr Nephrol 2009","DOI":"10.1007\/s00467-009-1260-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092642"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Biber J, Hernando N, Forster I, Murer H: Regulation of phosphate transport in proximal tubules. Pflugers Arch 458: 39-52, 2009","DOI":"10.1007\/s00424-008-0580-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.54.93"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K: Growth-related renal type II Na\/Pi cotransporter. J Biol Chem 277: 19665-19672, 2002","DOI":"10.1074\/jbc.M200943200"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000107069"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M: Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am J Physiol Renal Physiol 297: F350-361, 2009","DOI":"10.1152\/ajprenal.90765.2008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0776-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1086\/499409"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1086\/499410"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5372"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tenenhouse HS, Martel J, Gauthier C, Segawa H, Miyamoto K: Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c. Am J Physiol Renal Physiol 285: F1271-1278, 2003","DOI":"10.1152\/ajprenal.00252.2003"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1988.tb00966.x"},{"key":"21","unstructured":"21. Adams RG, Harrison JF, Scott P: The development of cadmium-induced proteinuria, impaired renal function, and osteomalacia in alkaline battery workers. Q J Med 38: 425-443, 1969"},{"key":"22","unstructured":"22. Ishizaki A, Funkushima M: [Studies on &rdquo;Itai-itai&rdquo; disease (Review)]. Nippon Eiseigaku Zasshi 23: 271-285, 1968 (in Japanese)"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tsuchiya K: Causation of Ouch-Ouch Disease (Itai-Itai Byo)--an introductory review. I. Nature of the disease. Keio J Med 18: 181-194, 1969","DOI":"10.2302\/kjm.18.181"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09356-8"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.8.1579"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377675"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(91)90123-N"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Takaki A, Jimi S, Segawa M, Hisano S, Takebayashi S, Iwasaki H: Long-term cadmium exposure accelerates age-related mitochondrial changes in renal epithelial cells. Toxicology 203: 145-154, 2004","DOI":"10.1016\/j.tox.2004.06.005"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Shimizu Y, Tada Y, Yamauchi M, Okamoto T, Suzuki H, Ito N, Fukumoto S, Sugimoto T, Fujita T: Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemia. Bone 45: 814-816, 2009","DOI":"10.1016\/j.bone.2009.06.017"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Schouten BJ, Hunt PJ, Livesey JH, Frampton CM, Soule SG: FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study. J Clin Endocrinol Metab 94: 2332-2337, 2009","DOI":"10.1210\/jc.2008-2396"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T: Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement. Bone 42: 1235-1239, 2008","DOI":"10.1016\/j.bone.2008.02.014"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Herak-Kramberger CM, Spindler B, Biber J, Murer H, Sabolic I: Renal type II Na\/Pi-cotransporter is strongly impaired whereas the Na\/sulphate-cotransporter and aquaporin 1 are unchanged in cadmium-treated rats. Pflugers Arch 432: 336-344, 1996","DOI":"10.1007\/s004240050141"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Brzoska MM, Majewska K, Moniuszko-Jakoniuk J: Mineral status and mechanical properties of lumbar spine of female rats chronically exposed to various levels of cadmium. Bone 34: 517-526, 2004","DOI":"10.1016\/j.bone.2003.12.002"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Segawa H, Onitsuka A, Kuwahata M, Hanabusa E, Furutani J, Kaneko I, Tomoe Y, Aranami F, Matsumoto N, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K: Type IIc sodium-dependent phosphate transporter regulates calcium metabolism. J Am Soc Nephrol 20: 104-113, 2009","DOI":"10.1681\/ASN.2008020177"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Selvaraj P, Prabhu Anand S, Harishankar M, Alagarasu K: Plasma 1,25 dihydroxy vitamin D3 level and expression of vitamin d receptor and cathelicidin in pulmonary tuberculosis. J Clin Immunol 29: 470-478, 2009","DOI":"10.1007\/s10875-009-9277-9"},{"key":"36","unstructured":"36. Yusufi AN, Dousa TP: Studies on rabbit kidney brush border membranes: relationship between phosphate transport, alkaline phosphatase and NAD. Miner Electrolyte Metab 13: 397-404, 1987"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1084-1"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K: Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol 297: F671-678, 2009","DOI":"10.1152\/ajprenal.00156.2009"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Segawa H, Yamanaka S, Ohno Y, Onitsuka A, Shiozawa K, Aranami F, Furutani J, Tomoe Y, Ito M, Kuwahata M, Imura A, Nabeshima Y, Miyamoto K: Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. Am J Physiol Renal Physiol 292: F769-779, 2007","DOI":"10.1152\/ajprenal.00248.2006"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)00068-9"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0777"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(92)90066-2"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1993.1134"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1147"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8180"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Segawa H, Yamanaka S, Ito M, Kuwahata M, Shono M, Yamamoto T, Miyamoto K: Internalization of renal type IIc Na-Pi cotransporter in response to a high-phosphate diet. Am J Physiol Renal Physiol 288: F587-596, 2005","DOI":"10.1152\/ajprenal.00097.2004"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Wolf M: Fibroblast growth factor 23 and the future of phosphorus management. Curr Opin Nephrol Hypertens 18: 463-468, 2009","DOI":"10.1097\/MNH.0b013e328331a8c8"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.45.431"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jmi\/57\/1,2\/57_1,2_95\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T18:08:03Z","timestamp":1621534083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jmi\/57\/1,2\/57_1,2_95\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":49,"journal-issue":{"issue":"1,2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.57.95","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}