{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:34:04Z","timestamp":1746322444503},"reference-count":25,"publisher":"University of Tokushima Faculty of Medicine","issue":"1.2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2018]]},"DOI":"10.2152\/jmi.65.85","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T22:23:56Z","timestamp":1522189436000},"page":"85-89","source":"Crossref","is-referenced-by-count":9,"title":["Role of Epiligament in Ligamentum Flavum Hypertrophy in Patients\u00a0 with Lumbar Spinal Canal Stenosis:a Pilot Study"],"prefix":"10.2152","volume":"65","author":[{"given":"Nori","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosaku","family":"Higashino","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K.","family":"Goel","sequence":"additional","affiliation":[{"name":"ECORE, Department of Bioengineering and Orthopedic Surgery, University of Toledo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Biyani","sequence":"additional","affiliation":[{"name":"ECORE, Department of Bioengineering and Orthopedic Surgery, University of Toledo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Ebraheim","sequence":"additional","affiliation":[{"name":"ECORE, Department of Bioengineering and Orthopedic Surgery, University of Toledo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuta","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Sairyo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Beamer YB, Garner JT, Shelden CH:Hypertrophied ligamentum flavum. Clinical and surgical significance. Archives of surgery (Chicago, Ill:1960) 106:289\u2010292, 1973","DOI":"10.1001\/archsurg.1973.01350150029008"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Park JB, Chang H, Lee JK:Quantitative analysis of transforming growth factor\u2010beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. Spine 26:E492\u2010495, 2001","DOI":"10.1097\/00007632-200111010-00007"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Towne EB, Reichert FL:Compression of the Lumbosacral Roots of the Spinal Cord by Thickened Ligamenta Flava. Annals of surgery 94:327\u2010336, 1931","DOI":"10.1097\/00000658-193109000-00002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ullrich CG, Binet EF, Sanecki MG, Kieffer SA:Quantitative assessment of the lumbar spinal canal by computed tomography. Radiology 134:137\u2010143, 1980","DOI":"10.1148\/radiology.134.1.7350593"},{"key":"5","unstructured":"5. Evans JH, Nachemson AL:Biomechanical study of human lumbar ligamentum flavum. Journal of anatomy 105:188\u2010189, 1969"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fukuyama S, Nakamura T, Ikeda T, Takagi K:The effect of mechanical stress on hypertrophy of the lumbar ligamentum flavum. Journal of spinal disorders 8:126\u2010130, 1995","DOI":"10.1097\/00002517-199504000-00006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nachemson AL, Evans JH:Some mechanical properties of the third human lumbar interlaminar ligament (ligamentum flavum). Journal of biomechanics 1:211\u2010220, 1968","DOI":"10.1016\/0021-9290(68)90006-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Nakatani T, Marui T, Hitora T, Doita M, Nishida K, Kurosaka M:Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor\u2010beta1. Journal of orthopaedic research:official publication of the Orthopaedic Research Society 20:1380\u20101386, 2002","DOI":"10.1016\/S0736-0266(02)00046-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Okuda T, Baba I, Fujimoto Y, Tanaka N, Sumida T, Manabe H, Hayashi Y, Ochi M:The pathology of ligamentum flavum in degenerative lumbar disease. Spine 29:1689\u20101697, 2004","DOI":"10.1097\/01.BRS.0000132510.25378.8C"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Olszewski AD, Yaszemski MJ, White AA, 3rd:The anatomy of the human lumbar ligamentum flavum. New observations and their surgical importance. Spine 21:2307\u20102312, 1996","DOI":"10.1097\/00007632-199610150-00001"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Postacchini F, Gumina S, Cinotti G, Perugia D, DeMartino C:Ligamenta flava in lumbar disc herniation and spinal stenosis. Light and electron microscopic morphology. Spine 19:917\u2010922, 1994","DOI":"10.1097\/00007632-199404150-00009"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ramsey RH:The anatomy of the ligamenta flava. Clinical orthopaedics and related research 44:129\u2010140, 1966","DOI":"10.1097\/00003086-196600440-00013"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Schrader PK, Grob D, Rahn BA, Cordey J, Dvorak J:Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis. European spine journal:official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 8:323\u2010328, 1999","DOI":"10.1007\/s005860050181"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Yoshida M, Shima K, Taniguchi Y, Tamaki T, Tanaka T:Hypertrophied ligamentum flavum in lumbar spinal canal stenosis. Pathogenesis and morphologic and immunohistochemical observation. Spine 17:1353\u20101360, 1992","DOI":"10.1097\/00007632-199211000-00015"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ikuta K, Arima J, Tanaka T, Oga M, Nakano S, Sasaki K, Goshi K, Yo M, Fukagawa S:Short\u2010term results of microendoscopic posterior decompression for lumbar spinal stenosis. Technical note. Journal of neurosurgery Spine 2:624\u2010633, 2005","DOI":"10.3171\/spi.2005.2.5.0624"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Wada K, Sairyo K, Sakai T, Yasui N:Minimally invasive endoscopic bilateral decompression with a unilateral approach (endo\u2010BiDUA) for elderly patients with lumbar spinal canal stenosis. Minimally invasive neurosurgery:MIN 53:65\u201068, 2010","DOI":"10.1055\/s-0030-1247559"},{"key":"17","unstructured":"17. Bray RC, Fisher AW, Frank CB:Fine vascular anatomy of adult rabbit knee ligaments. Journal of anatomy 172:69\u201079, 1990"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Chowdhury P, Matyas JR, Frank CB:The \u201cepiligament&quot; of the rabbit medial collateral ligament:a quantitative morphological study. Connective tissue research 27:33\u201050, 1991","DOI":"10.3109\/03008209109006993"},{"key":"19","unstructured":"19. Frank CB:Ligament structure, physiology and function. Journal of musculoskeletal &amp; neuronal interactions 4:199\u2010201, 2004"},{"key":"20","unstructured":"20. Mensor MC, Fender FA:The ligamentum flavum:Its relationship to low back pain. . Surg Gynecol Obstet 73:822\u2010827, 1941"},{"key":"21","unstructured":"21. Naffziger HC, Inman V, Saunders JB:Lesions of the intervertebral disc and ligamentum flava. Surg Gynecol Obstet 66:288\u2010299, 1938"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sairyo K, Biyani A, Goel V, Leaman D, Booth R, Jr., Thomas J, Gehling D, Vishnubhotla L, Long R, Ebraheim N:Pathomechanism of ligamentum flavum hypertrophy:a multidisciplinary investigation based on clinical, biomechanical, histologic, and biologic assessments. Spine 30:2649\u20102656, 2005","DOI":"10.1097\/01.brs.0000188117.77657.ee"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kosaka H, Sairyo K, Biyani A, Leaman D, Yeasting R, Higashino K, Sakai T, Katoh S, Sano T, Goel VK, Yasui N:Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis. Spine 32:2805\u20102811, 2007","DOI":"10.1097\/BRS.0b013e31815b650f"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Sairyo K, Biyani A, Goel VK, Leaman DW, Booth R, Jr., Thomas J, Ebraheim NA, Cowgill IA, Mohan SE:Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation\u2010related scar tissue. Spine 32:E340\u2010347, 2007","DOI":"10.1097\/01.brs.0000263407.25009.6e"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Matthews JL, Chung M, Matyas JR:Indirect injury stimulates scar formation\u2010adaptation or pathology? Connective tissue research 45:94\u2010100, 2004","DOI":"10.1080\/03008200490464794"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/65\/1.2\/65_85\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T02:02:28Z","timestamp":1623117748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/65\/1.2\/65_85\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":25,"journal-issue":{"issue":"1.2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.65.85","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}