{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T05:00:15Z","timestamp":1666501215799},"reference-count":30,"publisher":"University of Tokushima Faculty of Medicine","issue":"1.2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2020]]},"DOI":"10.2152\/jmi.67.70","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T22:07:01Z","timestamp":1588370821000},"page":"70-74","source":"Crossref","is-referenced-by-count":0,"title":["Effect of epigenetic modulation on cancer sphere"],"prefix":"10.2152","volume":"67","author":[{"given":"Shuichi","family":"Iwahashi","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Morine","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Imura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ikemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Llovet JM, Burroughs A, Bruix J\u2005:\u2005Hepatocellular carcinoma. Lancet 362\u2005:\u20051907-1917, 2003","DOI":"10.1016\/S0140-6736(03)14964-1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Farazi PA, DePinho RA\u2005:\u2005Hepatocellular carcinoma pathogenesis\u2005:\u2005from genes to environment. Nat Rev Cancer 6\u2005:\u2005674-687, 2006","DOI":"10.1038\/nrc1934"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. El-Serag HB\u2005:\u2005Hepatocellular carcinoma\u2005:\u2005an epidemiologic view. J Clin Gastroenterol 35\u2005:\u200572-78, 2002","DOI":"10.1097\/00004836-200211002-00002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Huang YH, Chen CH, Chang TT, Chen SC, Wang SY, Lee PC, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Chau GY, Chiang JH, Lui WY, Lee SD, Wu JC\u2005:\u2005The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma\u2005:\u2005a nation-wide, multicenter study. Liver Int 24\u2005:\u2005419-424, 2004","DOI":"10.1111\/j.1478-3231.2004.0941.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Wubetu GY, Utsunomiya T, Ishikawa D, Yamada S, Ikemoto T, Morine Y, Iwahashi S, Saito Y, Arakawa Y, Imura S, Kanamoto M, Zhu C, Bando Y, Shimada M\u2005:\u2005High STAT4 expression is a better prognostic indicator in patients with hepatocellular carcinoma after hepatectomy. Ann Surg Oncol 21 Suppl 4\u2005:\u2005S721-728, 2014","DOI":"10.1245\/s10434-014-3861-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Jordan CT, Guzman ML, Noble M\u2005:\u2005Cancer stem cells. N Engl J Med 355\u2005:\u20051253-1261, 2006","DOI":"10.1056\/NEJMra061808"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Dalerba P, Cho RW, Clarke MF\u2005:\u2005Cancer stem cells\u2005:\u2005models and concepts. Annu Rev Med 58\u2005:\u2005267-284, 2007","DOI":"10.1146\/annurev.med.58.062105.204854"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Shimada M, Sugimoto K, Iwahashi S, Utsunomiya T, Morine Y, Imura S, Ikemoto T\u2005:\u2005CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma. J Gastroenterol 45\u2005:\u2005896-902, 2010","DOI":"10.1007\/s00535-010-0235-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Lin CH, Shen YA, Hung PH, Yu YB, Chen YJ\u2005:\u2005Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines. BMC Complement Altern Med 12\u2005:\u2005201, 2012","DOI":"10.1186\/1472-6882-12-201"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Frame FM, Maitland NJ\u2005:\u2005Cancer stem cells, models of study and implications of therapy resistance mechanisms. Adv Exp Med Biol 720\u2005:\u2005105-118, 2011","DOI":"10.1007\/978-1-4614-0254-1_9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Haberland M, Montgomery RL, Olson EN\u2005:\u2005The many roles of histone deacetylases in development and physiology\u2005:\u2005Implications for disease and therapy. Nat Rev Genet 10\u2005:\u200532-42, 2009","DOI":"10.1038\/nrg2485"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Patra SK, Patra A, Dahiya R\u2005:\u2005Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem Biophys Res Commun 287\u2005:\u2005705-713, 2001","DOI":"10.1006\/bbrc.2001.5639"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lin RJ, Nagy L, Inoue S, Shao W, Miller WH Jr, Evans RM\u2005:\u2005Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391\u2005:\u2005811-814, 1998","DOI":"10.1038\/35895"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. G\u00f6ttlicher M, Minucci S, Zhu P, Kr\u00e4mer OH, Schimpf A, Giavara S, Sleeman JP, Lo Coco F, Nervi C, Pelicci PG, Heinzel T, Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20\u2005:\u20056969-6978, 2001","DOI":"10.1093\/emboj\/20.24.6969"},{"key":"15","unstructured":"15. Jones J, Bentas W, Blaheta RA, Makarevic J, Hudak L, Wedel S, Probst M, Jonas D, Juengel E\u2005:\u2005Modulation of adhesion and growth of colon and pancreatic cancer cells by the histone deacetylase inhibitor valproic acid. Int J Mol Med 22\u2005:\u2005293-299, 2008"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Iwahashi S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Hanaoka J, Saito Y\u2005:\u2005Histone deacetylase inhibitor enhances the anti-tumor effect of gemcitabine\u2005:\u2005a special reference to gene-expression microarray analysis. Oncol Rep 26\u2005:\u20051057-1062, 2011","DOI":"10.3892\/or.2011.1407"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Iwahashi S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Hanaoka J, Sugimoto K, Saito Y\u2005:\u2005Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-\u03b1 on pancreatic cancer cells. Int J Clin Oncol 16\u2005:\u2005671-678, 2011","DOI":"10.1007\/s10147-011-0246-y"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Iwahashi S, Ishibashi H, Utsunomiya T, Morine Y, Ochir TL, Hanaoka J, Mori H, Ikemoto T, Imura S, Shimada M\u2005:\u2005Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines. J Med Invest 58\u2005:\u2005106-109, 2011","DOI":"10.2152\/jmi.58.106"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Issa JP\u2005:\u2005CpG island methylator phenotype in cancer. Nat Rev Cancer 4\u2005:\u2005988-993, 2004","DOI":"10.1038\/nrc1507"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS\u2005:\u2005The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res 11\u2005:\u20058564-8569, 2005","DOI":"10.1158\/1078-0432.CCR-05-0859"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S\u2005:\u2005Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One 6\u2005:\u2005e24099, 2011","DOI":"10.1371\/journal.pone.0024099"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T\u2005:\u2005Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia. Epigenetics 8\u2005:\u2005584-590, 2013","DOI":"10.4161\/epi.24621"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Utsunomiya T, Shimada M, Morine Y, Tajima A, Imoto I\u2005:\u2005Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis. Cancer Sci 105\u2005:\u2005749-754, 2014","DOI":"10.1111\/cas.12431"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kong D, Banerjee S, Ahmad A, Li Y, Wang Z, Sethi S, Sarkar FH\u2005:\u2005Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One 5\u2005:\u2005e12445, 2010","DOI":"10.1371\/journal.pone.0012445"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Hollier BG, Evans K, Mani SA\u2005:\u2005The epithelial-to-mesenchymal transition and cancer stem cells\u2005:\u2005a coalition against cancer therapies. J Mammary Gland Biol Neoplasia 14\u2005:\u200529-43, 2009","DOI":"10.1007\/s10911-009-9110-3"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Polyak K, Weinberg RA\u2005:\u2005Transitions between epithelial and mesenchymal states\u2005:\u2005acquisition of malignant and stem cell traits. Nat Rev Cancer 9\u2005:\u2005265-273, 2009","DOI":"10.1038\/nrc2620"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Pellicano F, Holyoake TL\u2005:\u2005Assembling defenses against therapy-resistant leukemic stem cells\u2005:\u2005Bcl6 joins the ranks. J Exp Med 208\u2005:\u20052155-2158, 2011","DOI":"10.1084\/jem.20112087"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Zopf S, Ocker M, Neureiter D, Alinger B, Gahr S, Neurath MF, Di Fazio P\u2005:\u2005Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines. BMC Cancer 12\u2005:\u2005386, 2012","DOI":"10.1186\/1471-2407-12-386"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Warrell RP Jr, He LZ, Richon V, Calleja E, Pandolfi PP\u2005:\u2005Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst 90\u2005:\u20051621-1625, 1998","DOI":"10.1093\/jnci\/90.21.1621"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Blaheta RA, Michaelis M, Driever PH, Cinatl J Jr\u2005:\u2005Evolving anticancer drug valproic acid\u2005:\u2005insights into the mechanism and clinical studies. Med Res Rev 25\u2005:\u2005383-397, 2005","DOI":"10.1002\/med.20027"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/67\/1.2\/67_70\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T19:53:32Z","timestamp":1666468412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/67\/1.2\/67_70\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":30,"journal-issue":{"issue":"1.2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.67.70","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}