{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:43:15Z","timestamp":1787024595118,"version":"build-2736575974"},"reference-count":37,"publisher":"University of Tokushima Faculty of Medicine","issue":"3.4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2023]]},"DOI":"10.2152\/jmi.70.325","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T17:14:46Z","timestamp":1699463686000},"page":"325-333","source":"Crossref","is-referenced-by-count":5,"title":["Early enteral nutrition with arginine compensates for negative nitrogen balance in patients undergoing curative total gastrectomy"],"prefix":"10.2152","volume":"70","author":[{"given":"Yasuko","family":"Okamoto","sequence":"first","affiliation":[{"name":"Faculty of Home Economics, Aichi Gakusen University, Okazaki, Aichi, Japan"},{"name":"Clinical Nutritional Management, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Division of Surgery, Iwata City Hospital, Iwata, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Ikematsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"},{"name":"Surgery, Shizuoka City Shimizu Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadataka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Nishiwaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Hamamatsu Medical Center, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Weimann A, Braga M, Carli F, Higashiguchi T, H?bner M, Klek S, Laviano A, Ljungqvist O, Lobo DN, Martindale R, Waitzberg DL, Bischoff SC, Singer P:ESPEN guideline:Clinical nutrition in surgery. Clin Nutr 36:623-650, 2017 doi.org\/10.1016\/j.clnu.2017.02.013.","DOI":"10.1016\/j.clnu.2017.02.013"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. The Committee on Japanese Guidelines for Nutrition Support Therapy in the Adult and Pediatric Critically Ill Patients, Japanese Society of Intensive Care Medicine:Japanese guidelines for nutrition support therapy in the adult and pediatric critically ill patients. J Jpn Soc Intensive Care Med 23:185-281, 2016","DOI":"10.3918\/jsicm.23.185"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Braga M, Ljungqvist O, Soeters P, Fearon K, Weimann A, Bozzetti F, ESPEN:ESPEN guidelines on parenteral nutrition:surgery. Clin Nutr 28:378-386, 2009 doi.org\/10.1016\/j.clnu.2009.04.002","DOI":"10.1016\/j.clnu.2009.04.002"},{"key":"4","unstructured":"4. Canadian Clinical Practice Guidelines Committee:Highlights of the 2015 Canadian clinical practice guidelines. 3.3b. Intentional underfeeding:Hypocaloric enteral nutrition. 2015 Available at:https:\/\/www.criticalcarenutrition.com\/docs\/CPGs 202015\/3.3b 202015.pdf (accessed May 2022)"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Farreras N, Artigas V, Cardona D, Rius X, Trias M, Gonz?lez J A:Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin Nutr 24:55-65, 2005 doi.org\/10.1016\/j.clnu.2004.07.002","DOI":"10.1016\/j.clnu.2004.07.002"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Quirino IEP, Correia MITD, Cardosa VN:The impact of arginine on bacterial translocation in an intestinal obstruction model in rats. Clin Nutr 26:335-340, 2007 doi.org\/10.1016\/j.clnu.2006.12.007","DOI":"10.1016\/j.clnu.2006.12.007"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Fan J, Meng Q, Guo G, Xie Y, Li X, Xiu Y, Li T, Ma L:Effects of early enteral nutrition supplemented with arginine on intestinal mucosal immunity in severely burned mice. Clin Nutr 29:124-130, 2010 doi.org\/10.1016\/j.clnu.2009.07.005","DOI":"10.1016\/j.clnu.2009.07.005"},{"key":"8","unstructured":"8. Iyama JO, Adamson I:Effect of supplemental arginine on rehabilitation of the starved rat. Nutr Reports Int 26:335-345, 1982"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ha YH, Milner JA:Arginine requirements in immature dogs. J Nutr 108:203-210, 1978","DOI":"10.1093\/jn\/108.2.203"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Valentini L, Schuetz T, Allison S, Howard P, Pichardand C:ESPEN guidelines on enteral nutrition. Clin Nutr 25:175-360, 2006 doi.org\/10.1016\/j.clnu.2006.02.004","DOI":"10.1016\/j.clnu.2006.02.004"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G, A.S.P.E.N. Board of Directors;American College of Critical Care Medicine;Society of Critical Care Medicine:Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient:Society of critical care medicine (SCCM) and american society for parenteral and enteral nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr 33:277-316, 2009 doi.org\/10.1177\/0148607109335234","DOI":"10.1177\/0148607109335234"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Shimanuki M:Nitrogen balance and nitrogen utilization rate with special reference to protein-energy interactions. Eiyo To Shokuryo 31:41-48, 1978 (in Japanese)","DOI":"10.4327\/jsnfs1949.31.41"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Baker JP, Detsky AS, Wesson DE, Wolman SL, Stewart S, Whitewell J, Langer B, Jeejeebhoy KN:Nutritional assessment:a comparison of clinical judgment and objective measurements. N Engl J Med 306:969-972, 1982 doi.org\/10.1056\/NEJM198204223061606","DOI":"10.1056\/NEJM198204223061606"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Desky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, Jeejeebhoy KN:What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr 11:8-13, 1987 doi.org\/10.1177\/014860718701100108","DOI":"10.1177\/014860718701100108"},{"key":"15","unstructured":"15. Onodera T, Goseki N, Kosaki G:Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. J Jpn Surg Soc 85:1001-1005, 1984 (in Japanese)"},{"key":"16","unstructured":"16. Committee of Economics in American Society of Anesthesiologists:ASA physical status classification system. Last amended December 13, 2020. https:\/\/www.asahq.org\/standards-and-guidelines\/asa-physical-status-classification-system"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Florey CD:Sample size for beginners. Brit Med J 306:1181-1184, 1993 doi.org\/10.1136\/bmj.306.6886.1181","DOI":"10.1136\/bmj.306.6886.1181"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Kanda Y:Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant 48:452-458, 2013 doi.org\/10.1038\/bmt.2012.24","DOI":"10.1038\/bmt.2012.24"},{"key":"19","unstructured":"19. WHO:Protein and amino acid requirements in human nutrition, in:W. H. Organization (Ed.), Report of a joint FAO\/WHO\/UNU expert consultation. World Health Organ Tech Rep Ser 2007, 935. Geneva, Switzerland. Available at http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/43411\/WHO_TRS_935_eng.pdf (accessed May 2022)"},{"key":"20","unstructured":"20. VKM:Risk assessment of \u201cother substances\u201d L-arginine and arginine alpha-ketoglutarate. VKM Report 2016, 07. The Norwegian Scientific Committee for Food Safety. Available at https:\/\/vkm.no\/download\/18.645b840415d03a2fe8f26066\/1502798687898\/8b62ea4db0.pdf (accessed May 2022)"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Witte M B, Barbul A:Arginine physiology and its implication for wound healing. Wound Repair Regen 11:419-423, 2003 doi.org\/10.1046\/j.1524-475x.2003.11605.x","DOI":"10.1046\/j.1524-475X.2003.11605.x"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P:Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh) 99:18-23, 1982 doi.org\/10.1530\/acta.0.0990018","DOI":"10.1530\/acta.0.0990018"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Steffee CH, Wissler RW, Humphreys EM, Benditt EP, Woolridge RW, Cannon RR:Studies in amino acid utilization:V. The determination of minimum daily essential amino acid requirements in protein-depleted adult male albino rats:One figure. J Nutr 40:483-497, 1950 doi.org\/10.1093\/jn\/40.4.483","DOI":"10.1093\/jn\/40.4.483"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Minuskin ML, Lavine ME, Ulman EA, Fisher H:Nitrogen retention, muscle creatine and orotic acid excretion in traumatized rats fed arginine and glycine enriched diets. J Nutr 111:1265-1274, 1981 doi:10.1093\/jn\/111.7.1265","DOI":"10.1093\/jn\/111.7.1265"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Cui XL, Iwasa M, Iwasa Y, Ohmori Y, Yamamoto A, Maeda H, Kume M, Ogoshi S, Yokoyama A, Sugawara T, Funada T:Effects of dietary arginine supplementation on protein turnover and tissue protein synthesis in scald-burn rats. Nutrtion 15:563-569, 1999 doi:10.1016\/s0899-9007(99)00086-6","DOI":"10.1016\/S0899-9007(99)00086-6"},{"key":"26","unstructured":"26. Elsair J, Poey J, Issad H, Reggabi M, Bekri T, Hattab F, Spinner C:Effect of arginine chlorhydrate on nitrogen balance during the three days following routine surgery in man. Biomed Express 29:312-317, 1978 (in French)"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Daly JM, Reynolds J, Thom A, Kinsley L, Dietrick-Gallagher M, Shou J, Ruggieri B:Immune and metabolic effects of arginine in the surgical patient. Ann Surg 208:512-523, 1988","DOI":"10.1097\/00000658-198810000-00013"},{"key":"28","unstructured":"28. Elam RP, Hardin DH, Sutton RA, Hagen L:Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness 29:52-56, 1989"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Bertolini G, Iapichino G, Radrizzani D, Facchini R, Simini B, Bruzzone P, Zanforlin G, Tognoni G:Early enteral immunonutrition in patients with severe sepsis:results of an interim analysis of a randomized multicentre clinical. Intensive Care Med 29:834-840, 2003 doi.org\/10.1007\/s00134-003-1711-5","DOI":"10.1007\/s00134-003-1711-5"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Dent DL:Immunonutrition may increase mortality in critically ill patients with pneumonia:results of a randomized trial. Crit Care Med 30:A 17, 2002 doi.org\/10.1097\/00003246-200212001-00063","DOI":"10.1097\/00003246-200212001-00063"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Bliss DZ, Guenter PA, Settle RG:Defining and reporting diarrhea in tube-fed patients--what a mess! Am J Clin Nutr 55:753-759, 1992 doi.org\/10.1093\/ajcn\/55.3.753","DOI":"10.1093\/ajcn\/55.3.753"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Borthne AS, Dormagen JB, Gjesdal KI, Storaas T, Lygren I, Geitung JT:Bowel MR imaging with oral Gastrografin:an experimental study with healthy volunteers. Eur Radiol 13:100-106, 2003 doi:10.1007\/s00330-002-1528-6","DOI":"10.1007\/s00330-002-1528-6"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Buijs N, van Bokhorst-de van der Schueren MA, Langius JA, Leemans CR, Kuik DJ, Vermeulen MA, van Leeuwen PA:Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival. Am J Clin Nutr 92:1151-1156, 2010","DOI":"10.3945\/ajcn.2010.29532"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Kanekiyo S, Takeda S, Iida M, Nishiyama M, Kitahara M, Shindo Y, Tokumitsu Y, Tomochika S, Tsunedomi R, Suzuki N, Abe T, Yoshino S, Hazama S, Ueno T, Nagano H:Efficacy of perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy. Nutrition 59:96-102, 2019","DOI":"10.1016\/j.nut.2018.08.006"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Paddon-Jones D, Rasmussen BB:Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12:86-90, 2009","DOI":"10.1097\/MCO.0b013e32831cef8b"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB:Health ABC Study. Dietary protein intake is associated with lean mass change in order, community-dwelling adults:the healthy aging, and body composition (Health ABC) study. Am J Clin Nutr 87:150-155, 2008 doi.org\/10.1093\/ajcn\/87.1.150","DOI":"10.1093\/ajcn\/87.1.150"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Dindo D, Demartines N, Clavien PA:Classification of surgical complications:a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205-213, 2004","DOI":"10.1097\/01.sla.0000133083.54934.ae"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/70\/3.4\/70_325\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:22:46Z","timestamp":1715563366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/70\/3.4\/70_325\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":37,"journal-issue":{"issue":"3.4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.70.325","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}