{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:19:55Z","timestamp":1787505595017,"version":"build-2736575974"},"reference-count":45,"publisher":"University of Tokushima Faculty of Medicine","issue":"3.4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2024]]},"DOI":"10.2152\/jmi.71.210","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T18:13:43Z","timestamp":1729793623000},"page":"210-218","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass"],"prefix":"10.2152","volume":"71","author":[{"given":"Hideya","family":"Kashihara","sequence":"first","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Okikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Morine","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Takasu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Tsumura Kampo Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Zushi","sequence":"additional","affiliation":[{"name":"Tsumura Kampo Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Islam SM, Purnat TD, Phuong NT, Schacht UM, Fr\u00f6schl G : Non-communicable diseases (NCDs) in developing coun tries : a symposium report. Global Health 10 : 81 ; 10.1186\/s12992-014-0081-9, 2014","DOI":"10.1186\/s12992-014-0081-9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lavie, CJ, Milani RV, Ventura HO : Obesity and cardiovascular disease : risk factor, paradox, and impact of weight loss. J. Am. Coll. Cardiol 53 : 1925-1932, 2009","DOI":"10.1016\/j.jacc.2008.12.068"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Koh-Banerjee P, Wang Y, Hu F, Spiegelman D, Willett WC, Rimm EB : Changes in body weight and body fat distribu tion as risk factors for clinical diabetes in US men. Am. J. Epidemiol 159 : 1150-1159, 2004","DOI":"10.1093\/aje\/kwh167"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dobbins M, Decorby K, Choi BC : The association between obesity and cancer risk : a meta-analysis of observational studies from 1985 to 2011. ISRN Prev. Med 2013 : 680536, 2013","DOI":"10.5402\/2013\/680536"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Chan RS, Woo J : Prevention of overweight and obesity : how effective is the current public health approach. Int. J. Environ. Res. Public Health 7 : 765-783, 2010","DOI":"10.3390\/ijerph7030765"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Shariful Islam SM, Lechner A, Ferrari U, Laxy M, Seissler J, Brown J, Niessen LW, Holle R : Healthcare use and ex penditure for diabetes in Bangladesh. BMJ Glob. Health 2 : e000033, 2017","DOI":"10.1136\/bmjgh-2016-000033"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA : The effectiveness and risks of bariatric surgery. JAMA Surg 149 : 275-287, 2014","DOI":"10.1001\/jamasurg.2013.3654"},{"key":"8","unstructured":"8. Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Prato SD, Ji L, Sadikot SM, Herman WH, Amiel SA, Kaplan LM, Taroncher-Oldenburg G, Cummings DE, Delegates of the 2nd Diabetes Surgery Summit : Metabolic surgery in the treatment algorithm for type 2 diabetes. Diabetes Care 39 : 861-877, 2016"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Rubino F, Forgione A, Cummings DE, Vix M, Gnuli D, Mingrone G, Castagneto M, Marescaux J:The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann. Surg 244:741-749, 2006","DOI":"10.1097\/01.sla.0000224726.61448.1b"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kashihara H, Shimada M, Kurita N, Sato H, Yoshikawa K, Higashijima J, Chikakiyo M, Nishi M, Takasu C : Duo denal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids. J. Gastroenterol. Hepatol 30 : 308-15, 2015","DOI":"10.1111\/jgh.12690"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Nakao T, Nishi M, Takasu C : Duodenal-jejunal bypass changes the composition of the gut microbiota. Surg. Today 47 : 137-140, 2017","DOI":"10.1007\/s00595-016-1373-x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Miyatani T, Tokunaga T, Nishi M, Takasu C : Duodenal-je junal bypass maintains gut permeability by suppressing gut inflammation. Obes. Surg 29 : 2745-2749, 2019","DOI":"10.1007\/s11695-019-03922-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Seki Y, Kasama K, Umezawa A, Kurokawa Y : Laparoscopic sleeve gastrectomy with duodenojejunal bypass for type 2 diabetes mellitus. Obes. Surg 26 : 2035-2044, 2016","DOI":"10.1007\/s11695-016-2057-8"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kono T, Kanematsu T, Kitajima M : Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines : is it time yet? Surgery 146 : 837-840, 2019","DOI":"10.1016\/j.surg.2009.06.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, Zinsmeister AR, Haruma K : Effect of dai kenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am. J. Physiol. Gastrointest. Liver Physiol 298 : G970-G975, 2010","DOI":"10.1152\/ajpgi.00043.2010"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Iturrino J, Camilleri M, Wong BS, Nord SJ, Burton D, Zinsmeister AR : Randomised clinical trial : the effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation. Aliment. Pharmacol. Ther 37 : 776- 785, 2013","DOI":"10.1111\/apt.12264"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Okada K, Kawai M, Uesaka K, Kodera Y, Nagano H, Murakami Y, Morita S, Sakamoto J, Yamaue H, JAPAN-PD Investigators : Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy : a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study). Jpn. J. Clin. Oncol 43 : 436-438, 2013","DOI":"10.1093\/jjco\/hyt005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, Kono T, Kamiyama T, Morita S, Sakamoto J, Kusano M, Saji S, Kanematsu T, Kitajima M : Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer : a multi-center, phase III trial (JFMC40- 1001). Int. J. Clin. Oncol 20 : 95-104, 2015","DOI":"10.1007\/s10147-014-0678-2"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yoshikawa K, Shimada M, Wakabayashi G, Ishida K, Kaiho T, Kitagawa Y, Sakamoto J, Shiraishi N, Koeda K, Mochiki E, Saikawa Y, Yamaguchi K, Watanabe M, Morita S, Kitano S, Saji S, Kanematsu T, Kitajima M : Effect of Daikenchuto, a traditional Japanese herbal medicine, after total gastrectomy for gastric cancer : a multicenter, randomized, double-blind, placebo controlled, phase II trial. J. Am. Coll. Surg 221 : 571-578, 2015","DOI":"10.1016\/j.jamcollsurg.2015.03.004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, Noguchi M, Watanabe T : Daikenchuto (TU-100) amelio rates colon microvascular dysfunction via endogenous adrenomedullin in Crohn\u2019s disease rat model. J. Gastroenterol 46 : 1187-1196, 2011","DOI":"10.1007\/s00535-011-0438-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yoshikawa K, Kurita N, Higashijima J, Miyatani T, Miyamoto H, Nishioka M, Shimada M : Kampo medicine \u201cDaikenchu-to\u201d prevents bacterial translocation in rats. Dig. Dis. Sci 53 : 1824-1831, 2008","DOI":"10.1007\/s10620-008-0281-3"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chikakiyo M, Shimada M, Nakao T, Higashijima J, Yoshikawa K, Nishioka M, Iwata T, Kurita N:Kampo medicine \u201cDai-kenchu-to\u201d prevents CPT-11-induced small-intestinal injury in rats. Surg. Today 42:60-67, 2012","DOI":"10.1007\/s00595-011-0014-7"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Yoshikawa K, Shimada M, Kuwahara T, Hirakawa H, Kurita N, Sato H, Utsunomiya T, Iwata T, Miyatani T, Higashijima J, Kashihara H, Takasu C, Matsumoto N, Nakayama-Imaohji H : Effect of Kampo medicine \u201cDai-kenchu-to\u201d on microbiome in the intestine of the rats with fast stress. J. Med. Invest 60 : 221-227, 2013","DOI":"10.2152\/jmi.60.221"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G, Eid GM, Mattar S, Ramanathan R, Barinas-Mitchel E, Rao RH, Kuller L, Kelley D : Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Annals of Surgery 238 : 467-484, 2003","DOI":"10.1097\/01.sla.0000089851.41115.1b"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Fried M, Ribaric G, Buchwald JN, Svacina S, Dolezalova K, Scopinaro N : Metabolic surgery for the treatment of type 2 diabetes in patients with BMI <35 kg \/ m2 : an integrative review of early studies. Obes. Surgery20 : 776-790, 2010","DOI":"10.1007\/s11695-010-0113-3"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Quercia I, Dutia R, Kotler DP, Belsley S, Laferr\u00e8re B : Gastrointestinal changes after bariatric surgery. Diabetes Metab 40 : 87-94, 2014","DOI":"10.1016\/j.diabet.2013.11.003"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Wang G, Agenor K, Pizot J, Kotler DP, Harel Y, Schueren BJ, Quercia I, McGinty J, Laferr\u00e8re B : Accelerated gastric emptying but no carbohydrate malabsorption 1 year after gastric bypass surgery (GBP). Obes. Surg 22 : 1263-1267, 2012","DOI":"10.1007\/s11695-012-0656-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Stano S, Alam F, Wu L, Dutia R, Ng SN, Sala M, McGinty J, Laferr\u00e8re B : Effect of meal size and texture on gastric pouch emptying and glucagon-like peptide 1 after gastric bypass surgery. Surg. Obes. Relat. Dis 13 : 1975-1983, 2017","DOI":"10.1016\/j.soard.2017.09.004"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Steinert RE, Feinle-Bisset C, Asarian L, Horowitz M, Beglinger C, Geary N : Ghrelin, CCK, GLP-1, and PYY(3- 36) : secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB. Physiol. Rev 97 : 411-463, 2016","DOI":"10.1152\/physrev.00031.2014"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Ockander L, Hedenbro JL, Rehfeld JF, Sj\u00f6lund K : Jejunoileal bypass changes the duodenal cholecystokinin and somatostatin cell density. Obes. Surg 13 : 584-590, 2003","DOI":"10.1381\/096089203322190781"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Oliv\u00e1n B, Teixeira J, Bose M, Bawa B, Chang T, Summe H, Lee H, Laferr\u00e8re B : Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. Ann. Surg 249 : 948-953, 2009","DOI":"10.1097\/SLA.0b013e3181a6cdb0"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Vidal J, Nicolau J, Romero F, Casamitjana R, Momblan D, Conget I, Mor\u00ednigo R, Lacy AM : Long-term effects of Roux-en-Y gastric bypass surgery on plasma glucagon-like peptide-1 and islet function in morbidly obese subjects. J. Clin. Endocrinol. Metab 94 : 884-891, 2009","DOI":"10.1210\/jc.2008-1620"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A, L\u00f6nroth H, F\u00e4ndriks L, Ghatei MA, Bloom SR, Olbers T : Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann. Surg 246 : 780-785, 2007","DOI":"10.1097\/SLA.0b013e3180caa3e3"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Mor\u00ednigo R, Moiz\u00e9 V, Musri M, Lacy AM, Navarro S, Mar\u00edn JL, Delgado S, Casamitjana R, Vidal J:Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J. Clin. Endocrinol. Metab 91:1735-40, 2006","DOI":"10.1210\/jc.2005-0904"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Laferr\u00e8re B, Swerdlow N, Bawa B, Arias S, Bose M, Oliv\u00e1n B, Teixeira J, McGinty J, Rother KI : Rise of oxyntomodulin in response to oral glucose after gastric bypass surgery in patients with type 2 diabetes. J. Clin. Endocrinol. Metab 95 : 4072-4076, 2010","DOI":"10.1210\/jc.2009-2767"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Miyatani T, Tokunaga T, Nishi M, Takasu C : The effect of Roux-en-Y reconstruction on type 2 diabetes in the early postoperative period. Anticancer Res 38 : 4901-4905, 2018","DOI":"10.21873\/anticanres.12805"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H : Colonic pro-inflammatory macrophages cause insulin resistance in an intestinal Ccl2 \/ Ccr2-dependent manner. Cell Metab 24 : 295-310, 2016","DOI":"10.1016\/j.cmet.2016.07.009"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD : High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 137 : 1716-1724, 2009","DOI":"10.1053\/j.gastro.2009.08.042"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM : Selective increases of bifidobacteria in gut microflora improve high-fat-dietinduced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50 : 2374-2783, 2007","DOI":"10.1007\/s00125-007-0791-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Li L, Ma L, Fu P : Gut microbiota-derived short-chain fatty acids and kidney diseases. Drug Des. Devel. Ther 11 : 3531- 3542, 2017","DOI":"10.2147\/DDDT.S150825"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Larsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, Pedersen BK, Al-Soud WA, S\u00f8rensen SJ, Hansen LH, Jakobsen M : Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS ONE 5. 5 : e9085, 2010","DOI":"10.1371\/journal.pone.0009085"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Murri M, Leiva I, Gomez-Zumaquero JM, Tinahones FJ, Cardona F, Soriguer F, Queipo-Ortu\u00f1o MI : Gut microbiota in children with type 1 diabetes differs from that in healthy children : a case-control study. BMC Med 11 : 46, 2013","DOI":"10.1186\/1741-7015-11-46"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Kakiyama G, Pandak WM, Gillevet PM, Hylemon PB, Heuman DM, Takei KD, Muto A, Nittono H, Ridlon JM, White MB, Noble NA, Monteith P, Fuchs M, Thacker LR, Sikaroodi M, Bajaj JS : Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J. Hepatol 58 : 949-955, 2013","DOI":"10.1016\/j.jhep.2013.01.003"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ohigashi S, Sudo K, Kobayashi D, Takahashi O, Takahashi T, Asahara T, Nomoto K, Onodera H : Changes of the in testinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer. Dig. Dis. Sci 58 : 1717-1726, 2013","DOI":"10.1007\/s10620-012-2526-4"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Caesar R, Tremaroli V, Kovatcheva-Datchary P, Cani PD, B\u00e4ckhed F : Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling. Cell Metab 22 : 658-668, 2015","DOI":"10.1016\/j.cmet.2015.07.026"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/71\/3.4\/71_210\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:59:09Z","timestamp":1729904349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/71\/3.4\/71_210\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":45,"journal-issue":{"issue":"3.4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.71.210","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}