{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:17:45Z","timestamp":1788635865501,"version":"build-2803163510"},"reference-count":45,"publisher":"University of Tokushima Faculty of Medicine","issue":"3.4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2024]]},"DOI":"10.2152\/jmi.71.286","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T22:13:52Z","timestamp":1729808032000},"page":"286-292","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Ischemic Penumbra and Prognosis in acute Cerebral Infarction Using Cerebral Blood Flow and Delay Time Derived from Multi-delay pCASL Imaging"],"prefix":"10.2152","volume":"71","author":[{"given":"Mihoko","family":"Sasahara","sequence":"first","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriaki","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Otomo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"GE Healthcare Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Goyal M, Menon BK, Coutts SB, Hill MD, Demchuk AM : Effect of baseline CT scan appearance and time to recanalization on clinical outcomes in endovascular thrombectomy of acute ischemic strokes. Stroke 42 : 93-7, 2011","DOI":"10.1161\/STROKEAHA.110.594481"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Detre JA, Leigh JS, Williams DS, Koretsky AP : Perfusion imaging. Magn Reson Med 23 : 37-45, 1992","DOI":"10.1002\/mrm.1910230106"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Detre JA, Zhang W, Roberts DA, Silva AC, Williams DS, Grandis DJ, Koretsky AP, Liegh JS : Tissue specific perfusion imaging using arterial spin labeling. NMR in Biomedicine 7 : 75-82, 1994","DOI":"10.1002\/nbm.1940070112"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wu B, Lou X, Wu X, Ma L : Intra- and inter-scanner reliability and reproducibility of 3D whole-brain pseudo con tinuous arterial spin-labeling MR perfusion on 3T. J Magn Reson Imaging 39 : 402-409, 2014","DOI":"10.1002\/jmri.24175"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Wang DJ, Alger JR, Qiao JX, Gunther M, Pope WB, Saver JL, Salamon N, Liebeskind DS : Multi-delay multi-para metric arterial spin-labeled perfusion MRI in acute ischemic stroke - Comparison with dynamic susceptibility contrast enhanced perfusion imaging. Neuroimage Clinical 3 : 1-7, 2013","DOI":"10.1016\/j.nicl.2013.06.017"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wang DJ, Alger JR, Qiao JX, Hao Q, Hou S, Fiaz R, Gunther M,Pope WB, Saver JL, Salamon N, Liebeskind DS : The value of arterial spin-labeled perfusion imaging in acute ischemic stroke : comparison with dynamic susceptibility contrast-enhanced MRI. Stroke 43 : 1018-1024, 2012","DOI":"10.1161\/STROKEAHA.111.631929"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Lyu JH, Ma N, Liebeskind DS, Wang DJ, Ma L, Xu Y, Wang T, Miao Z, Lou X : Arterial spin labeling magnetic resonance imaging estimation of antegrade and collateral flow in unilateral middle cerebral artery stenosis. Stroke 47 : 428-433, 2016","DOI":"10.1161\/STROKEAHA.115.011057"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Liebeskind DS : Collateral Circulation. Stroke 34 : 2279- 2284, 2003","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Alsop DC, Detre JA, Golay X, G\u00fcnther M, Hendrikse J, Garcia LH, Lu H, Maclntosh BJ, Parkes LM, Smits M, Osch MJ, wang DJ, Wong EC, Zaharchuk G : Recommended implementation of Arterial Spin-Labeled perfusion MRI for clinical applications. A consensus of the ISMRM Perfusion Study group and the European consortium for ASL in dementia. Magn Reson Med 73 : 102-116, 2015","DOI":"10.1002\/mrm.25197"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Buxton RB, Frank LR, Wong EC, Siewert WB, Warach S, Edelman RR : A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn Reson Med 40 : 383-396, 1998","DOI":"10.1002\/mrm.1910400308"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Lou X, Yu S, Scalzo F, Starkman S, Ali LK, Kim D, Pao NM, Hinman JD, Vespa PM, Jahan R, Tateshima S, Gonzalez NR, Duckwiler GR, Saver JL, Yoo B, Salamon N, Lyu J, Ma L, Wang DJ, Liebeskind DS : Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke. Oncotarget 8 : 2437-2443, 2017","DOI":"10.18632\/oncotarget.13898"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kawano H, Bivard A, Lin L, Spratt NJ, Miteff F, Parsons MW, Levi CR : Relationship Between Collateral Status, Contrast Transit, and Contrast Density in Acute Ischemic Stroke. Stroke 47 : 742-749, 2016","DOI":"10.1161\/STROKEAHA.115.011320"},{"key":"13","unstructured":"13. Christoforidis GA, Mohammad Y, Kehagias D, Avutu B, Slivka AP : Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 26 : 1789-1797, 2005"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Villringer K, Sandoval RS, Grittner U, Galinovic I, Schneider A, Ostwaldt AC, Brunecker P, Rocco A, Fiebach JB : Subtracted Dynamic MR Perfusion Source Images (sMRP-SI) provide Collateral Blood Flow Assessment in MCA Occlusions and Predict Tissue Fate. European Radiology 26 : 1396-1403, 2016","DOI":"10.1007\/s00330-015-3927-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Berkhemer OA, Jansen IG, Beumer D, Fransen PS, van den Berg LA, Yoo AJ, Lingsma HF, Sprengers ME, Jenniskens SF, Lycklama ANGJ, van Walderveen MA, van den Berg R, Bot JC, Beenen LF, Boers AM, Slump CH, Roos YB, van Oostenbrugge RJ, Dippel DW, van der Lugt A, van Zwam WH, Marquering HA, Majoie CB : Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke. Stroke 47 : 768-776, 2016","DOI":"10.1161\/STROKEAHA.115.011788"},{"key":"16","unstructured":"16. Nougueria RG, Jadhav AP, Haussen DC, Bonafe A, Budzik R, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila GA, Hassan AE:Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med 378:11-21, 2018"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Dai W, Shankaranarayanan A, Alsop DC : Volumetric measurement of perfusion and arterial transit delay using Hadamard encoded continuous arterial spin labeling. Magn Reson Med 69 : 1014-1022, 2013","DOI":"10.1002\/mrm.24335"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Dai W, Robson PM, Shankaranarayanan A, Alsop DC : Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging. Magn Reson Med 67 : 1252-1265, 2012","DOI":"10.1002\/mrm.23103"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Wang J, Alsop DC, Li L, Listerud J, Gonzalez-At JB, Schnall MD, Detre JA : Comparison of quantitative per-fu sion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med 48 : 242-254, 2002","DOI":"10.1002\/mrm.10211"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Zaharchuk G : Arterial spin label imaging of acute ischemic stroke and transient ischemic attack. Neuroimaging clinics of North America 21 : 285-301, 2011","DOI":"10.1016\/j.nic.2011.01.003"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zaharchuk G, Do HM, Marks MP, Rosenberg J, Moseley ME, Steinberg GK : Arterial spin-labeling mri can identify the presence and intensity of collateral perfusion in patients with moyamoya disease. Stroke 42 : 2485-2491, 2011","DOI":"10.1161\/STROKEAHA.111.616466"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chalela JA, Alsop DC, Gonzalez-Atavales JB, Maldjian JA, Kasner SE, Detre JA : Magnetic resonance perfusion imag ing in acute ischemic stroke using continuous arterial spin labeling. Stroke 31 : 680-687, 2000","DOI":"10.1161\/01.STR.31.3.680"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wu B, Wang X, Guo J, Xie S, Wong EC, Zhang J, Jiang X, Fang J : Collateral circulation imaging : MR perfusion ter ritory arterial spin-labeling at 3t. AJNR Am J Neuroradiol 29 : 1855-1860, 2008","DOI":"10.3174\/ajnr.A1259"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chng SM, Petersen ET, Zimine I, Sitoh YY, Lim CC, Golay X : Territorial arterial spin labeling in the assessment of collateral circulation : Comparison with digital subtraction angiography. Stroke 39 : 3248-3254, 2008","DOI":"10.1161\/STROKEAHA.108.520593"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Weiying Dai, Tamara Fong, Richard N. Jones, Edward Marcantonio, Eva Schmitt, Sharon K, Alsop DC : Effects of Arterial Transit Delay on Cerebral Blood Flow Quantification using Arterial Spin Labeling in an Elderly Cohort. J Magn Reson Imaging 45 : 472-481, 2017","DOI":"10.1002\/jmri.25367"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Dai W, Robson PM, Shankaranarayanan A, Alsop DC : A Reduced Resolution Transit Delay Prescan for Quantitative Continuous Arterial Spin Labeling Perfusion Imaging. BosMagn Reson Med 67 : 1252-1265, 2012","DOI":"10.1002\/mrm.23103"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Havenon AD, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB : Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurol 74 : 453-458, 2017","DOI":"10.1001\/jamaneurol.2016.4491"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Mutke MA, Madai VI, von Samson-Himmelstjerna FC, Weber OZ, Revankar GS, Martin SZ, Stengl KL, Bauer M, Hetzer S, Gunther M, Sobesky J : Clinical evaluation of an arterial-spin-labeling product sequence in steno-occlusive disease of the brain. PLoS One 9 : 87-143, 2019","DOI":"10.1371\/journal.pone.0087143"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ : Dynamic imaging with lanthanide chelates in normal brain : contrast due to magnetic susceptibility effects. Magn Reson Med 6 : 164-174, 1988","DOI":"10.1002\/mrm.1910060205"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Engelhorn T, Doerfler A, Forsting DM, Heusch G, Schulz R : Does a relative perfusion measure predict cerebral in farct size?. AJNR Am J Neuroradiol 26 : 2218-2223, 2005","DOI":"10.1055\/s-2004-833229"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Schlaug G, Benfield A, Baird AE, Siewert B, L\u00f6vblad KO, Parker RA, Edelman RR, Warach S:The ischemic penumbra:operationally defined by diffusion and perfusion MRI. Neurology 53:1528-1537,1999","DOI":"10.1212\/WNL.53.7.1528"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. K Butcher, M Parsons, T Baird, A Barber, G Donnan, P Desmond, Tress B, Davis S : Perfusion thresholds in acute stroke thrombolysis. Stroke 34 : 2159-2164, 2003","DOI":"10.1161\/01.STR.0000086529.83878.A2"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Leigh R, Knutsson L, Zhou J, Zijl PC : Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke. J Cereb Blood Flow Metab 38 : 1500-1516, 2018","DOI":"10.1177\/0271678X17700913"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Finelli DA, Hopkins AL, Selman WR, Crumrine RC, Bhatti SU, Lust WD : Evaluation of experimental early acute cerebral ischemia before the development of edema : Use of dynamic, contrast-enhanced and diffusion-weighted MR scanning. Magn Reson Med 27 : 189-197, 1992","DOI":"10.1002\/mrm.1910270119"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Hamberg LM, Macfarlane R, Tasdemiroglu E, Boccalini P, Hunter GJ, Bwlliveau JW, Moskowitz MA, Rosen BR : Mea surement of cerebrovascular changes in cats after transient ischemia using dynamic magnetic resonance imaging. Stroke 24 : 444-451, 1993","DOI":"10.1161\/01.STR.24.3.444"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Shah S, Luby M, Poole K, Morella T, Keller E, Benson RT, Lynch JK, Nadareishvili Z, Hsia, AW : Screening with MRI for accurate and rapid stroke treatment : SMART. Neurology 84 : 2438-2444, 2015","DOI":"10.1212\/WNL.0000000000001678"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Zaharchuk G, El Mogy IS, Fischbein NJ, Albers GW : Comparison of arterial spin labeling and bolus perfusion-weight ed imaging for detecting mismatch in acute stroke. Stroke 43 : 1843-1848, 2012","DOI":"10.1161\/STROKEAHA.111.639773"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Bokkers RP, Hernandez DA, Merino JG, Mirasol RV, van Osch MJ, Hendrikse J, Warach S, Latour LL : Wholebrain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke 43 : 1290-1294, 2012","DOI":"10.1161\/STROKEAHA.110.589234"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW : Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke. Stroke 40 : 469-475, 2019","DOI":"10.1161\/STROKEAHA.108.526954"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Calamante F, Christensen S, Desmond PM, \u00d8stergaard L, Davis SM, Connelly A : The Physiological Significance of the Time-to-Maximum (Tmax) Parameter in Perfusion MRI. Stroke 41 : 1169-1174, 2010","DOI":"10.1161\/STROKEAHA.110.580670"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Harston GW, Okell TW, Sheerin F, Schulz W, Mathieson P, Reckless I, Shah K, Ford GA, Chappell MA, Jezzard P, Kennedy J : Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling. Stroke 48 : 123- 130, 2017","DOI":"10.1161\/STROKEAHA.116.014707"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Huang YC, Liu HL, Lee JD, Yang JT, Weng HH, Lee M, Yeh MY, Tsai YH : Comparison of Arterial Spin Labeling and Dynamic Susceptibility Contrast Perfusion MRI in Patients with Acute Stroke. PLoS ONE 8 : 1-6, 2013","DOI":"10.1371\/journal.pone.0069085"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Marks MP, Lansberg MG, Mlynash M, Olivot JM, Straka M, Kemp S, Taggart RM, Inoue M, Zaharchuk G, Bammer R, Albers GW : Effect of Collateral Blood Flow on Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke. Stroke 45 : 1035-1039, 2014","DOI":"10.1161\/STROKEAHA.113.004085"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Faizy TD, Kabiri R, Christensen S, Mlynash M, Kuraitis G, Broocks G, Hanning Y, Nawabi J, Lansberg MG, Marks MP, Albers GW, Fiehler J, Wintermark M, Heit JJ : Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion. Journal of Cerebral Blood Flow & Metabolism 41 : 2067-2075, 2021","DOI":"10.1177\/0271678X21992200"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Guenego A, Marcellus DG, Martin BW, Christensen S, Albers GW, Lansberg MG, Marks MP, Wintermark M, Heit JJ : Hypoperfusion Intensity Ratio Is Correlated With Patient Eligibility for Thrombectomy. Stroke 50 : 917-922, 2019","DOI":"10.1161\/STROKEAHA.118.024134"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/71\/3.4\/71_286\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T04:59:17Z","timestamp":1729918757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/71\/3.4\/71_286\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":45,"journal-issue":{"issue":"3.4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.71.286","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"value":"1343-1420","type":"print"},{"value":"1349-6867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}