{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:53:23Z","timestamp":1765601603203,"version":"3.48.0"},"reference-count":15,"publisher":"University of Tokushima Faculty of Medicine","issue":"3.4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Invest."],"published-print":{"date-parts":[[2025]]},"DOI":"10.2152\/jmi.72.286","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:07:24Z","timestamp":1762207644000},"page":"286-289","source":"Crossref","is-referenced-by-count":0,"title":["Increase in the amyotrophic lateral sclerosis age of onset:Analysis of cases originating in 2011-2020"],"prefix":"10.2152","volume":"72","author":[{"given":"Kenta","family":"Hanada","sequence":"first","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"},{"name":"Naka Municipal Kaminaka Hospital, Naka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"},{"name":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"},{"name":"Department of Neurology, Nara Medical University School of Medicine, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"925","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Arthur KC, Calvo A, Price TR, Geiger JT, Chi\u00f2 A, Traynor BJ:Projected increase in amyotrophic lateral sclerosis from 2015 to 2040. Nat Commun 7:12408, 2016","DOI":"10.1038\/ncomms12408"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chi\u00f2 A, Logroscino G, Traynor BJ, Collins J, Simeone JC, Goldstein LA, White LA:Global epidemiology of amyotrophic lateral sclerosis:a systematic review of the published literature. Neuroepidemiology 41:118-130, 2013","DOI":"10.1159\/000351153"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kahana E, Zilber N:Changes in the incidence of amyotrophic lateral sclerosis in Israel. Arch Neurol 41:157-160, 1984","DOI":"10.1001\/archneur.1984.04050140055023"},{"key":"4","first-page":"377","volume":"46","author":"T Shimohata","year":"2006","unstructured":"4. Shimohata T, Yanagawa K, Tanaka K, Nishizawa M:[Longitudinal analysis of age at onset and initial symptoms in patients with amyotrophic lateral sclerosis]. Rinsho Shinkeigaku 46:377-380, 2006","journal-title":"Rinsho Shinkeigaku","ISSN":"https:\/\/id.crossref.org\/issn\/0009-918X","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kihira T, Yoshida S, Okamoto K, Kazimoto Y, Ookawa M, Hama K, Miwa H, Kondo T:Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005. J Neurol Sci 268:95-101, 2008","DOI":"10.1016\/j.jns.2007.11.011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chi\u00f2 A, Mora G, Moglia C, Manera U, Canosa A, Cammarosano S, Ilardi A, Bertuzzo D, Bersano E, Cugnasco P, Grassano M, Pisano F, Mazzini L, Calvo A:Secular Trends of Amyotrophic Lateral Sclerosis:The Piemonte and Valle d\u2019Aosta Register. JAMA Neurol 74:1097-1104, 2017","DOI":"10.1001\/jamaneurol.2017.1387"},{"key":"7","unstructured":"7. Japan Intractable Diseases Information Center. Available from https:\/\/www.nanbyou.or.jp\/entry\/5354. Accessed September, 2024."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G:Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener 16:230-236, 2015","DOI":"10.3109\/21678421.2014.990036"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Millul A, Beghi E, Logroscino G, Micheli A, Vitelli E, Zardi A:Survival of patients with amyotrophic lateral sclerosis in a population-based registry. Neuroepidemiology 25:114-119, 2005","DOI":"10.1159\/000086353"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Geevasinga N, Loy CT, Menon P, de Carvalho M, Swash M, Schrooten M, Van Damme P, Gawel M, Sonoo M, Higashihara M, Noto Y, Kuwabara S, Kiernan MC, Macaskill P, Vucic S:Awaji criteria improves the diagnostic sensitivity in amyotrophic lateral sclerosis:A systematic review using individual patient data. Clin Neurophysiol 127:2684-2691, 2016","DOI":"10.1016\/j.clinph.2016.04.005"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mehta PR, Jones AR, Opie-Martin S, Shatunov A, Iacoangeli A, Al Khleifat A, Smith BN, Topp S, Morrison KE, Shaw PJ, Shaw CE, Morgan S, Pittman A, Al-Chalabi A:Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias. J Neurol Neurosurg Psychiatry 90:268-271, 2019","DOI":"10.1136\/jnnp-2018-319089"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, M\u00fcller K, Marroquin N, Nordin F, H\u00fcbers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordstr\u00f6m U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Br\u00e4nnstr\u00f6m T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH:Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 18:631-636, 2015","DOI":"10.1038\/nn.4000"},{"key":"13","unstructured":"13. Tokushima Prefecture. https:\/\/www.pref.tokushima.lg.jp\/statistics\/month\/jinkou Accessed September, 2024."},{"key":"14","unstructured":"14. Statistics Bureau of Japan. https:\/\/www.stat.go.jp\/data\/topics\/topi1135.html 2018. Accessed September, 2024."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang MD, Little J, Gomes J, Cashman NR, Krewski D:Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. Neurotoxicology 61:101-130, 2017","DOI":"10.1016\/j.neuro.2016.06.015"}],"container-title":["The Journal of Medical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/72\/3.4\/72_286\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:51:48Z","timestamp":1765601508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jmi\/72\/3.4\/72_286\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":15,"journal-issue":{"issue":"3.4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2152\/jmi.72.286","relation":{},"ISSN":["1343-1420","1349-6867"],"issn-type":[{"type":"print","value":"1343-1420"},{"type":"electronic","value":"1349-6867"}],"subject":[],"published":{"date-parts":[[2025]]}}}