{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T05:24:36Z","timestamp":1703136276366},"reference-count":0,"publisher":"Global Cardiology Science and Practice","issue":"4","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gcsp"],"abstract":"<jats:p>Background:\u00a0Cardiovascular disease starts early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with end-stage renal disease. Since high-sensitivity cardiac troponin T (hs-cTnT) can detect much lower levels of myocardial injury than\u00a0conventional\u00a0assays, it may be useful for studying the earliest stages of heart disease in patients with CKD.Objective:\u00a0To evaluate the association of circulating hs-cTnT with LV structural and functional abnormalities detected by echocardiography among dialysis dependent and non-dialysis dependent CKD patients.Methods:\u00a0This study was conducted on 107 subjects divided into three groups.Group I consisted of CKD patients on conservative treatment (n=42), Group II: hemodialysis patients (n=42), Group III: control group: age and sex matched healthy volunteers (n=23). All subjects were subjected to clinical examination, biochemical evaluation including estimation of hs-cTnT and Echo-Doppler study of cardiac structure and function.Results:\u00a0There was a significant increase in LAV (p&lt;0.01), LVM (p&lt;0.01) in both patient groups compared to the control group.\u00a0Mitral annular plane systolic excursion (MAPSE) was significantly decreased in both patient groups compared to the control group (p&lt;0.01, p&lt;0.05) and in group I compared to group II (p&lt;0.05) with a significant decrease in S velocity in group I compared to groups II and III (p&lt;0.01). There was a significant decrease in Vp (p&lt;0.01) with a significant increase in AEF (p&lt;0.01) in both patients\u2019 groups compared to the control group and AEF was significantly increased in group II compared to group I (p&lt;0.01). Ea velocity and Ea\/Aa decreased significantly (p&lt;0.01) with significant increase in Aa velocity (p&lt;0.05, p&lt;0.01), E\/Ea (p&lt;0.01) and E\/Vp (p&lt;0.05) in both patient groups compared to the control group.\u00a0There was a significant increase in hs-cTnT levels in both patient groups compared to the control group (P&lt;0.01). We found a positive correlation between hs-cTnT levels and LAV (r=0.291, p&lt;0.03), IVST (r=0.374, p&lt;0.004), PWT (r=0.309, p&lt;0.02), LVM (r=0.282, p&lt;0.03), A wave velocity (r=0.271, p&lt;0.04), E\/Ea (r=0.506, p&lt;0.0001), PCWP (r=.507, p&lt; 0.0001) and a negative correlation between hs-cTnT and MAPSE (r=-0.300, p&lt;0.02), S wave velocity (r= -0.259, p&lt;0.05), Ea (r=-626, p&lt;0.0001), Ea\/Aa (r=-0.543, p&lt;0.0001).\u00a0Troponin at the cut-off value of &gt;5 ng\/L, revealed 100% sensitivity and 95% specificity with areas under curve (AUC) of 0.998 and accuracy of 95.65% (P&lt;0.01) for discrimination of Group I vs control group and 76.2% sensitivity and 95.7% specificity with AUC 0.796 and accuracy 71.84% (P&lt;0.01) for discrimination of group II vs control group.\u00a0Conclusion:\u00a0Structural and functional cardiac abnormalities are common in CKD patients. Serum hs-cTnT levels increased in CKD patients and was associated with LVH, LAV and some of the echocardiographic parameters of LV systolic and diastolic dysfunction.\u00a0Our research suggests that hs-cTnT levels may be\u00a0important for early screening\u00a0of cardiac structure and function in CKD patients to provide evidence for early intervention.<\/jats:p>","DOI":"10.21542\/gcsp.2021.26","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T21:09:15Z","timestamp":1659820155000},"source":"Crossref","is-referenced-by-count":1,"title":["Value of troponin T as a screening test of cardiac structure and function in chronic kidney disease"],"prefix":"10.21542","volume":"2021","author":[{"given":"Fatma M.","family":"Nasr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Metwaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf Abdel","family":"Khalik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manar","family":"Raafat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Nabil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8990","published-online":{"date-parts":[[2021,12,31]]},"container-title":["Global Cardiology Science and Practice"],"original-title":[],"link":[{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/viewFile\/538\/460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/viewFile\/538\/460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T21:09:18Z","timestamp":1659820158000},"score":1,"resource":{"primary":{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/view\/538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,31]]}},"URL":"https:\/\/doi.org\/10.21542\/gcsp.2021.26","relation":{},"ISSN":["2305-7823"],"issn-type":[{"value":"2305-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}