{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:09:32Z","timestamp":1793822972317,"version":"4.6.1"},"reference-count":0,"publisher":"Global Cardiology Science and Practice","issue":"4","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gcsp"],"abstract":"<jats:p>\n\n\nardiovascular diseases (CVDs) remain a major global health issue, with atherosclerosis being a primary driver of their development. Atherosclerosis is driven by oxidative stress, chronic inflammation, and lipid dysregulation, which ultimately lead to endothelial dysfunction and plaque formation. Resveratrol, a polyphenolic compound found in grapes and red wine, has emerged as a promising therapeutic agent due to its multivalent protective effects against atherosclerosis. This review outlines the role of resveratrol in the inhibition of key pathologic processes, including suppression of pro-inflammatory signaling pathways, enhancement of antioxidant defense mechanisms, and regulation of cholesterol homeostasis. Resveratrol inhibits NF-\u03baB activation, resulting in decreased vascular inflammation and reduced expression of adhesion molecules such as Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Cell Adhesion Molecule-1 (ICAM-1), thereby preventing infiltration of immune cells into arterial vessels. Additionally, it increases cholesterol efflux by promoting ATP-binding cassette transporters (ABCA1), enhancing high-density lipoprotein (HDL) function, and lowering lipid levels. Evidence from preclinical and clinical studies suggests that resveratrol holds potential as a natural treatment for the prevention of atherosclerosis.\n\n\n<\/jats:p>","DOI":"10.21542\/gcsp.2025.39","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T02:55:21Z","timestamp":1756090521000},"source":"Crossref","is-referenced-by-count":1,"title":["Resveratrol and atherosclerosis: A comprehensive review of its cardioprotective mechanisms and therapeutic potential"],"prefix":"10.21542","volume":"2025","author":[{"given":"Razan","family":"Moghnieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kheir","family":"Chahine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyad","family":"Mroweh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim","family":"Chaarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa","family":"Zalzali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh-Yezan","family":"Abdulaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Yazbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Raheb Khelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan","family":"Abdulaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8990","published-online":{"date-parts":[[2025,8,24]]},"container-title":["Global Cardiology Science and Practice"],"original-title":[],"link":[{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/876\/669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/876\/669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T02:55:21Z","timestamp":1756090521000},"score":1,"resource":{"primary":{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/view\/876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,24]]}},"URL":"https:\/\/doi.org\/10.21542\/gcsp.2025.39","relation":{},"ISSN":["2305-7823"],"issn-type":[{"value":"2305-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,24]]}}}