{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:52:13Z","timestamp":1777679533785,"version":"3.51.4"},"reference-count":0,"publisher":"Global Cardiology Science and Practice","issue":"6","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gcsp"],"abstract":"<jats:p>5-Fluorouracil (5-FU) is a fluorinated pyrimidine chemotherapy analogue used to treat various gastrointestinal solid malignancy. It is known to be associated with cardiotoxicity. Here, we present a case of 58-year-old male with mucinous adenocarcinoma of the sigmoid colon who experienced global coronary vasospasm in setting of continuous 5-FU infusion refractory to prophylactic antianginal treatment. However, he was asymptotic when given bolus of 5-FU. Our case highlights the difference in toxicity between continuous and bolus 5-FU therapy and emphasizes the need for further research in the pathophysiology and treatment of cardiotoxicity related to 5-FU therapy.<\/jats:p>","DOI":"10.21542\/gcsp.2025.61","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T05:43:32Z","timestamp":1767246212000},"source":"Crossref","is-referenced-by-count":1,"title":["When delivery matters: Diffuse coronary vasospasm with continuous, but not bolus, 5-FU infusion"],"prefix":"10.21542","volume":"2025","author":[{"given":"Muhammad","family":"Sabri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinya","family":"Talukder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angad","family":"Bedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hae","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8990","published-online":{"date-parts":[[2025,12,31]]},"container-title":["Global Cardiology Science and Practice"],"original-title":[],"link":[{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/944\/698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/944\/698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T05:43:32Z","timestamp":1767246212000},"score":1,"resource":{"primary":{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/view\/944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,31]]}},"URL":"https:\/\/doi.org\/10.21542\/gcsp.2025.61","relation":{},"ISSN":["2305-7823"],"issn-type":[{"value":"2305-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}