{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:06Z","timestamp":1789693386504,"version":"4.0.1"},"reference-count":0,"publisher":"Global Cardiology Science and Practice","issue":"4","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gcsp"],"abstract":"<jats:p>Background: Diabetes mellitus (DM) markedly increases the risk of coronary artery disease (CAD), and myocardial perfusion imaging (MPI) is a key noninvasive tool for risk stratification. Sex-based differences in presentation, referral patterns, and diagnostic accuracy of MPI remain understudied, particularly in Middle Eastern populations with a high prevalence of diabetes. This study evaluated sex-based differences in the indications, results, appropriateness, and diagnostic accuracy of MPI among diabetic Egyptian patients.\nMethods: This retrospective observational registry study included 1,000 diabetic adults (648 men, 352 women) who underwent gated SPECT-MPI at our university hospitals. Demographic data, risk factors, ECG findings, stress modalities, MPI results, coronary angiography data, and appropriate use criteria (AUC) were analyzed.\nResults: Men were older than women (59.6 \u00b1 8.0 vs. 57.0 \u00b1 9.4 years, p &lt; 0.001). Hypertension was more prevalent in women (84.1% vs. 67.6%, p &lt; 0.001), whereas smoking was more common in men (30.4% vs. 0.3%, p &lt; 0.001). Positive MPI results were more frequent in men (77.0% vs. 43.2%, p &lt; 0.001), as were appropriate indications (79.3% vs. 53.4%, p &lt; 0.001); inappropriate and uncertain indications were correspondingly more common in women. Reversible perfusion defects did not differ significantly by sex (23.6% in women vs. 21.2% in men, p = 0.523), whereas fixed defects were more prevalent in men (17.0% vs. 7.8%, p &lt; 0.001). MPI accuracy relative to coronary angiography did not differ significantly between the sexes (91.7% in men vs. 86.3% in women, p = 0.103).\nConclusion: Substantial sex-based disparities exist in MPI referral patterns, test positivity, and appropriateness among diabetic Egyptians. Women are more likely to receive inappropriate referrals and to have a lower positive diagnostic yield, underscoring the need for sex-sensitive clinical protocols.<\/jats:p>","DOI":"10.21542\/gcsp.2026.35","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:06:25Z","timestamp":1788221185000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients: A retrospective registry study"],"prefix":"10.21542","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-3698","authenticated-orcid":false,"given":"Hazem mohamed abdelmoneim","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2578-4428","authenticated-orcid":false,"given":"Osama Mohamed Mohamed","family":"Alzebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-9417","authenticated-orcid":false,"given":"Amr","family":"Adel Alsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-7993","authenticated-orcid":false,"given":"Ahmed Ibrahim El-Desoky","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8990","published-online":{"date-parts":[[2026,8,31]]},"container-title":["Global Cardiology Science and Practice"],"original-title":[],"link":[{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/1234\/763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/download\/1234\/763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:10:16Z","timestamp":1789690216000},"score":1,"resource":{"primary":{"URL":"https:\/\/globalcardiologyscienceandpractice.com\/index.php\/gcsp\/article\/view\/1234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.21542\/gcsp.2026.35","relation":{},"ISSN":["2305-7823"],"issn-type":[{"value":"2305-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}