{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:49Z","timestamp":1790248549618,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":2005,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2007,7,8]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> Chemotherapy of non\u2010Hodgkin lymphoma (NHL) with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is associated with significant gonadal damage. Our goal was to determine the impact of CHOP chemotherapy on the male reproductive system, fertility, and progeny outcome in the rat model. Adult male Sprague\u2010Dawley rats received saline or CHOP, 4 cycles of 3 weeks each, at doses analogous to 1\/3\u00d7, 2\/3\u00d7, or 1\u00d7 the human dose; males were mated to evaluate effects on progeny outcome. Reproductive organ weights were significantly decreased in the 1\u00d7 CHOP\u2014exposed group. The spermatozoal contents of the testes and epididymides were decreased in 1\u00d7 CHOP\u2014treated males; the 1\/3\u00d7 and 2\/3\u00d7 doses also affected testicular sperm contents. Seminiferous tubule diameters were decreased by 20% in 1\u00d7 CHOP\u2014treated males. Damage ranged from the presence of small vacuoles in the epithelium to tubules deprived of spermatocytes and spermatids and was accompanied by an increased incidence of germ cell apoptosis. The acridine orange assay revealed a significant increase in sperm with abnormal DNA integrity profiles in the 1\u00d7 CHOP group. Despite effects on germ cell number and quality, CHOP\u2010exposed rats remained fertile. However, a 50% decrease in live fetuses was observed in litters sired by 1\u00d7 CHOP\u2014treated males due to a significant increase in both pre\u2010implantation and postimplantation losses; postimplantation loss was also elevated among litters sired by 2\/3\u00d7 CHOP\u2014treated males. Thus, CHOP treatment affected both the quantity and quality of male germ cells; conceptal loss is a sensitive measure of the integrity of the male genome.<\/jats:p>","DOI":"10.2164\/jandrol.106.002428","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T20:00:56Z","timestamp":1182542456000},"page":"578-587","source":"Crossref","is-referenced-by-count":39,"title":["Effects of the Chemotherapeutic Agents for Non\u2010Hodgkin Lymphoma, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), on the Male Rat Reproductive System and Progeny Outcome"],"prefix":"10.1002","volume":"28","author":[{"given":"Farida","family":"Vaisheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Delbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara F.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Robaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.25.SpecialIssue_95"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19991101)284:6<696::AID-JEZ11>3.0.CO;2-E"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh671"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod36.4.915"},{"key":"e_1_2_6_6_1","first-page":"802","article-title":"Long\u2010term outcome of localized high\u2010grade non\u2010Hodgkin's lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study 1","volume":"90","author":"Bernard M.","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.6.1490"},{"key":"e_1_2_6_8_1","unstructured":"Canadian Cancer Statistics 2006. 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