{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:52:57Z","timestamp":1792853577730,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":2005,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2007,7,8]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> Four groups (minimum of 10\/dose group) of male Dutch\u2010belted rabbits were treated daily with dibromoacetic acid (DBA) via drinking water beginning in utero from gestation day 15 to adulthood; target dosages were 1, 5, and 50 mg DBA\/kg body weight. Developmental, prepubertal as well as postpubertal reproductive sequelae were evaluated. One (out of 22), 2 (out of 32), and 1 (out of 21) male offspring in the 1, 5, and 50 mg DBA\/kg groups were unilaterally cryptorchid. There were no significant differences in serum follicle\u2010stimulating hormone, luteinizing hormone, and testosterone (basal concentrations or in response to exogenous gonadotropin\u2010releasing hormone) in both prepubertal and adult rabbits. Chronic exposure to DBA adversely affected the mating abilities of some rabbits. The number of sperm produced was not affected, but spermiogenesis was disrupted, resulting in unique sperm acrosomal\u2010nuclear malformations even at the 1\u2010mg dose level. Concentrations of SP22, a specific sperm membrane fertility protein, in detergent extracts of ejaculated sperm were significantly lower (<jats:italic>P<\/jats:italic> &lt; .05) in all DBA\u2010treated groups compared with controls. The conception rates following artificial insemination of a constant number of sperm for 1, 5, and 50 mg DBA\/kg groups were 55% (10\/18), 65% (13\/20), and 55% (9\/16), respectively, vs 85% (17\/20) for control group. Histologic lesions in testes characterized by spermatogenic arrest predominantly at the round spermatid stage, pyknosis of differentiating germ cells, and ultimate degeneration and desquamation leaving focal vacuolation in seminiferous epithelium were evident in DBA\u2010treated groups. Thus, male rabbits exhibit reproductive toxicity with exposure to DBA during reproductive development at dosages as low as 1 mg\/kg body weight.<\/jats:p>","DOI":"10.2164\/jandrol.107.002550","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T20:00:56Z","timestamp":1182542456000},"page":"565-577","source":"Crossref","is-referenced-by-count":31,"title":["Chronic Exposure to Low Levels of Dibromoacetic Acid, a Water Disinfection By\u2010product, Adversely Affects Reproductive Function in Male Rabbits"],"prefix":"10.1002","volume":"28","author":[{"given":"D. N. R.","family":"Veeramachaneni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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