{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:44:18Z","timestamp":1790963058579,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2009,7,8]]},"abstract":"<jats:p>\n                    <jats:bold>ABSTRACT:<\/jats:bold>\n                    Ejaculation disorders are associated with tamsulosin treatment for lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH). To assess whether tamsulosin has any effect on semen, sperm parameters were evaluated in healthy men receiving tamsulosin, alfuzosin, and placebo. Forty\u2010eight healthy men received 5 days of tamsulosin 0.8 mg once daily (QD), alfuzosin 10 mg QD, and placebo in a randomized, double\u2010blind, 3\u2010way crossover study with a 10\u201014\u2010day washout period between treatments. The changes (x\u0304 \u00b1 SE) from baseline in semen sperm concentration, semen sperm count, semen viscosity, semen fructose, sperm motility, and sperm morphology on day 5 of treatment were assessed. The change from baseline in semen sperm concentration was 3.1 \u00b1 8.3 million\/mL with tamsulosin, 15.0 \u00b1 6.5 million\/mL with alfuzosin, and 24.4 \u00b1 6.5 million\/mL with placebo. The total sperm count in semen decreased from baseline with tamsulosin (\u221254.6 \u00b1 24.0 million) but not with placebo (81.5 \u00b1 18.8 million) or alfuzosin (46.2 \u00b1 19.0 million). The percentage of men with normal semen viscosity was lower with tamsulosin (65%) than with placebo (98%) or alfuzosin (92%). The change from baseline in semen fructose was comparable for all treatments. The percentage of motile sperm decreased 13.8% from baseline to day 5 of treatment with tamsulosin compared with decreases of 2.3% with placebo and 0.4% with alfuzosin. The percentage of abnormal sperm increased marginally with tamsulosin (0.6%) but not with placebo (\u22122.8%) or alfuzosin (\u22123.9%). The most common adverse events were dizziness (alfuzosin 11%, tamsulosin 14%, placebo 0%) and orthostatic hypotension (alfuzosin 25%, tamsulosin 11%, placebo 5%). The results suggest that tamsulosin has a negative effect on sperm in healthy men. Studies on the effects of \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    \u2010adrenergic blockers on sperm in men with BPH are warranted.\n                  <\/jats:p>","DOI":"10.2164\/jandrol.108.006874","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T12:07:45Z","timestamp":1247659665000},"page":"469-474","source":"Crossref","is-referenced-by-count":36,"title":["Effects of Alfuzosin and Tamsulosin on Sperm Parameters in Healthy Men: Results of a Short\u2010Term, Randomized, Double\u2010Blind, Placebo\u2010Controlled, Crossover Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Wayne J. G.","family":"Hellstrom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Sikka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04590.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)80121-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04674.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.05.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06426.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.06.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01535.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052316"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00257-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7234-3266-1.50008-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0302-2838(03)00154-4","article-title":"Prostatic tissual distribution of alfuzosin in patients with benign prostatic hyperplasia following repeated oral administration","volume":"44","author":"Mottet N.","year":"2003","journal-title":"Eur Urol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)01042-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04309.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00563-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.074740"},{"key":"e_1_2_6_18_1","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Semen\u2014Cervical Mucus Interaction","author":"Organization World Health","year":"1999"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2164%2Fjandrol.108.006874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.2164\/jandrol.108.006874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T10:02:45Z","timestamp":1697104965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.2164\/jandrol.108.006874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7,8]]}},"alternative-id":["10.2164\/jandrol.108.006874"],"URL":"https:\/\/doi.org\/10.2164\/jandrol.108.006874","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1164355.626082","asserted-by":"object"}]},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,8]]}}}