{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:05:09Z","timestamp":1773047109259,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":782,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2010,11,12]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> To assess the effect of experimental Type 1 diabetes on male fertility, male Sprague Dawley rats were injected with either streptozotocine (STZ) to induce diabetes or with citrate buffer as controls. Diabetic animals and 2 control groups (STZ\u2010resistant and buffer\u2010injected rats) were sacrificed at 2 different times after injection: 6 weeks (6W) and 20 weeks (20W). We analyzed serum testosterone (sTT), epididymal sperm parameters, and weight of testicles and epididymides, and carried out a histological evaluation of testicular tissue. Diabetic animals presented a significant increase in teratozoospermia (20W, <jats:italic>P<\/jats:italic> &lt; .01) and a decrease in sTT (<jats:italic>P<\/jats:italic> &lt; .01), tubular diameter (6W, <jats:italic>P<\/jats:italic> &lt; .05), and testicular (6W, <jats:italic>P<\/jats:italic> &lt; .01) and epididymal (<jats:italic>P<\/jats:italic> &lt; .01) weight. STZ\u2010resistant animals showed significantly decreased sTT (6W, <jats:italic>P<\/jats:italic> &lt; .01), epididymal weight (6W, <jats:italic>P<\/jats:italic> &lt; .05), and sperm count (6W, <jats:italic>P<\/jats:italic> &lt; .01) compared with buffer\u2013injected controls. Experimental STZ diabetes increases teratozoospermia and decreases sTT, testicular weight (reverting at medium\u2010term), and epididymal weight.<\/jats:p>","DOI":"10.2164\/jandrol.108.007260","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T23:24:30Z","timestamp":1289604270000},"page":"584-592","source":"Crossref","is-referenced-by-count":106,"title":["Effect of Experimental Diabetes and STZ on Male Fertility Capacity. Study in Rats"],"prefix":"10.1002","volume":"31","author":[{"given":"L.","family":"Navarro\u2010Casado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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