{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:35:34Z","timestamp":1767065734838},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":607,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2011,5,6]]},"abstract":"<jats:p><jats:bold>ABSTRACT:<\/jats:bold>Previously, we reported that estrogen receptor \u03b1 mRNA (<jats:italic>Esr1<\/jats:italic>) or protein (ESR1) overexpression resulting from neonatal exposure to estrogens in rats was associated with infertility and maldeveloped penis characterized by reduced length and weight and abnormal accumulation of fat cells. The objective of this study was to determine if mutant male mice overexpressing<jats:italic>Esr1<\/jats:italic>are naturally infertile or have reduced fertility and\/or develop abnormal penis. The fertility parameters, including fertility and fecundity indices, numbers of days from the day of cohabitation to the day of delivery, and numbers of pups per female, were not altered from controls as a result of<jats:italic>Esr1<\/jats:italic>overexpression. Likewise, penile morphology, including the length, weight, and diameter and os penis development, was not altered from controls. Conversely, weights of the seminal vesicles and bulbospongiosus and levator ani (BS\/LA) muscles were significantly (<jats:italic>P<\/jats:italic>&lt; .05) lower as compared with controls; however, the weight of the testis, the morphology of the testis and epididymis, and the plasma and testicular testosterone concentration were not different from controls. Hence, genetically induced<jats:italic>Esr1<\/jats:italic>overexpression alone, without an exogenous estrogen exposure during the neonatal period, is unable to adversely affect the development of the penis as well as other male reproductive organs, except for limited, but significant, reductions in weights of the seminal vesicles and BS\/LA muscles.<\/jats:p>","DOI":"10.2164\/jandrol.110.010769","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T19:38:18Z","timestamp":1301945898000},"page":"282-294","source":"Crossref","is-referenced-by-count":7,"title":["Genetically Induced Estrogen Receptor \u03b1 mRNA (<i>Esr1<\/i>) Overexpression Does Not Adversely Affect Fertility or Penile Development in Male Mice"],"prefix":"10.1002","volume":"32","author":[{"given":"John","family":"Heath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazeed","family":"Abdelmageed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D.","family":"Braden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessie","family":"Paulose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Hernandez\u2010Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi A.","family":"Flaws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari O.","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1210\/endo.141.10.7723","article-title":"Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationships to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels","volume":"141","author":"Atanassova N.","year":"2000","journal-title":"Endocrinology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1210\/endo.142.2.7978","article-title":"Age\u2010, cell\u2010 and region\u2010specific immunoexpression of estrogen receptor \u03b1 (but not estrogen receptor \u03b2) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol","volume":"142","author":"Atanassova N.","year":"2001","journal-title":"Endocrinology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.114-a644"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.11.5496"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-105-5-1128"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.1.379"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.11.8895349"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56240-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.1.90"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0326"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.026328"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi233"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2005.tb02869.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2003.12.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.071951"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.010637"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001900404"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1996.0005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/37352"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/j.1939-4640.1997.tb02437.x","article-title":"Estrogen receptor (\u03b1 and \u03b2) expression in the excurrent ducts of the adult male rat reproductive tract","volume":"18","author":"Hess RA","year":"1997","journal-title":"J Androl"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016376100186"},{"key":"e_1_2_6_23_1","first-page":"109","article-title":"Developmental pattern of estrogen receptor expression in male mouse genital organs","volume":"6","author":"Iguchi T.","year":"1991","journal-title":"Mol Androl"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070290604"},{"key":"e_1_2_6_25_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute of Laboratory Animal Resources, National Research Council","year":"1996"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220628"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15677"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.3.4979"},{"key":"e_1_2_6_29_1","first-page":"1435","volume-title":"The Physiology of Reproduction","author":"Luke MC","year":"1994"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/651419"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.036301"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10545"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.242076"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2001.d01-119.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.041012"},{"key":"e_1_2_6_36_1","first-page":"53","article-title":"The penis: a new target and source of estrogen in male reproduction","volume":"21","author":"Mowa CN","year":"2006","journal-title":"Histol Histopath"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.11.033"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.10059"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650359"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.5.1801"},{"key":"e_1_2_6_41_1","first-page":"6089","article-title":"Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor \u03b1: studies with \u03b1ERKO and \u03b2ERKO mice","volume":"61","author":"Prins GS","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.10.001"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.5.1506"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0660433"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(94)90021-3"},{"key":"e_1_2_6_46_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/j.1939-4640.1992.tb01653.x","article-title":"Testosterone and spermatogenesis: identification of stage\u2010specific, androgen\u2010regulated proteins secreted by adult rat seminiferous tubules","volume":"13","author":"Sharpe RM","year":"1992","journal-title":"J Androl"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6522"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2000.tb00001.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.04.007"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl040"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.08.004"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90006-X"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.96104s4741"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.5936"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod42.3.533"},{"key":"e_1_2_6_56_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1289\/ehp.011091227","article-title":"Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens","volume":"109","author":"Williams K.","year":"2001","journal-title":"Environ Health Perspect"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-5-2456"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2164%2Fjandrol.110.010769","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.2164\/jandrol.110.010769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T18:49:01Z","timestamp":1712342941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.2164\/jandrol.110.010769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,6]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5,6]]}},"alternative-id":["10.2164\/jandrol.110.010769"],"URL":"https:\/\/doi.org\/10.2164\/jandrol.110.010769","archive":["Portico"],"relation":{},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,6]]}}}