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Using this model, the role of Hyaluronan Binding Protein 1 (HABP1), which expresses a stage specifically in post\u2010meiotic cells during spermatogenesis, was examined. Cryptorchidism induced complete arrest of spermatogenesis by 2 days, and by 3\u20135 days many large and small multinucleated giant cells populated the affected tubules. Ultrastructure of the giant cells revealed both single and multiple chromatin aggregation, with some less compact and distorted, and others broken down into tiny fragments. These cells along with other germ cells were stained terminal deoxynucleotidyl transferase dUTP nick\u2010end labeling positive, demonstrating strong expression of Bax and Heat Shock Protein 70. Simultaneously, there was an up\u2010regulation of the proprotein form of HABP1 in these cells and a decrease in the mature form of protein. The above findings indicate a possible role for HABP1 proprotein in apoptosis induction of germ cells in the cryptorchid testes.<\/jats:p>","DOI":"10.2164\/jandrol.110.011320","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T20:30:45Z","timestamp":1323376245000},"page":"114-121","source":"Crossref","is-referenced-by-count":12,"title":["Simultaneous Accumulation of Hyaluronan Binding Protein 1 (HABP1\/p32\/gC1qR) and Apoptotic Induction of Germ Cells in Cryptorchid Testis"],"prefix":"10.1002","volume":"33","author":[{"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man 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