{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:03:07Z","timestamp":1791914587733,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2012,3,4]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. The aim of this study was to evaluate both EPCs and EMPs in patients with arterial erectile dysfunction (ED) and metabolic syndrome (MetS). To accomplish this, 100 patients (ages 45\u201360 years) with ED and MetS (Adult Treatment Panel III [ATP III] 1999 criteria) and 17 healthy men (ages 44\u201357 years) were selected. EPC (CD45<jats:sub>neg<\/jats:sub>\/CD34<jats:sub>pos<\/jats:sub>\/CD144<jats:sub>pos<\/jats:sub>) and EMP (CD45<jats:sub>neg<\/jats:sub>\/CD144<jats:sub>pos<\/jats:sub>\/Annexin V<jats:sub>pos<\/jats:sub>) blood concentrations were evaluated by flow cytometry, before and after administration of tadalafil (20 mg) on demand for 3 months. Before treatment, EPCs and EMPs were significantly higher in patients compared with healthy men. EPCs increased significantly after tadalafil administration, whereas EMPs did not differ significantly. EPCs correlated positively or negatively with body mass index and with some cavernous artery indices, both before and after tadalafil administration. EMPs showed only positive correlations with body mass index and some cavernous artery indices, both before and after tadalafil administration. Patients with arterial ED and MetS have higher EPCs and EMPs compared with healthy men; hence, these cells may be regarded as markers of cavernous artery dysfunction. Tadalafil administration increased EPCs but not EMPs, suggesting that this compound may play a role in the endothelial repair response.<\/jats:p>","DOI":"10.2164\/jandrol.111.013136","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T18:45:52Z","timestamp":1327603552000},"page":"202-209","source":"Crossref","is-referenced-by-count":29,"title":["Circulating Endothelial Progenitor Cells and Endothelial Microparticles in Patients With Arterial Erectile Dysfunction and Metabolic Syndrome"],"prefix":"10.1002","volume":"33","author":[{"given":"Sandro","family":"La Vignera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Vicari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"D'Agata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo E.","family":"Calogero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000124104.23702.a0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl202"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.1.8416651"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000231507.00962.b5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.04.002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000097001.79750.78"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4985"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01310.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036596.59665.C6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00823.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901500"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01042.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl198"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2000.0643"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.12.2417.2417"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901311"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.08.052"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01520.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901465"},{"key":"e_1_2_5_22_1","first-page":"284","article-title":"Androgens stimulate endothelial progenitor cells through an androgen receptor\u2010mediated pathway","volume":"68","author":"Foresta C.","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615904"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00309.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.069"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.026"},{"key":"e_1_2_5_27_1","first-page":"355","article-title":"Relationship between metabolic syndrome and erectile dysfunction","volume":"6","author":"G\u00fcnd\u00fcz MI","year":"2004","journal-title":"Asian J Androl"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.101"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.155960"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1509"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143161.01901.BD"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.050385"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1831"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-005-0070-8"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.09.031"},{"key":"e_1_2_5_36_1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","author":"National Cholesterol Education Program (NCEP)","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1595"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152908785849071"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472"},{"key":"e_1_2_5_40_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0025-6196(11)62632-3","article-title":"Erectile dysfunction and cardiovascular disease","volume":"79","author":"Russel ST","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01275.x"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.527135"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00662.2006"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S955"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64071-2"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000131784.50633.4f"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144972"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000137877.89448.78"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2008.41"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000083812.30141.74"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00994-X"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2164%2Fjandrol.111.013136","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.2164\/jandrol.111.013136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:34:53Z","timestamp":1698644093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.2164\/jandrol.111.013136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3,4]]}},"alternative-id":["10.2164\/jandrol.111.013136"],"URL":"https:\/\/doi.org\/10.2164\/jandrol.111.013136","archive":["Portico"],"relation":{},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}